Beneficial Effects of Algerian Green Alga Ulva lactuca and Its Hydroethanolic Extract on Insulin Resistance and Cholesterol Reverse Transport in High-Fat/Streptozotocin Diabetic Rats

Labbaci, F.Z.; Boukortt, Farida

doi:10.3746/pnf.2020.25.4.353

Cited by 9 publications

(4 citation statements)

References 53 publications

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“…Fibre, particularly water-soluble fibre, becomes more viscous in food, slowing the process of absorption of nutrients such as glucose. As a result, fibre consumption has a beneficial effect on blood glucose levels in people with diabetes [ 47 ]. Ahn et al [ 42 ] proposed that fibre reduces the activity of digestive enzymes and the level of food penetration, supported by their finding that consumption of rice analogues with a fibre content of up to 22.1% significantly lowered blood sugar levels in diabetic rats (Δ 175 mg/dL).…”

Section: Resultsmentioning

confidence: 99%

Blood Sugar, Haemoglobin and Malondialdehyde Levels in Diabetic White Rats Fed a Diet of Corn Flour Cookies

Aini

Sustriawan

Wahyuningsih

et al. 2022

Foods

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The purpose of the study was to analyse the chemical composition of corn cookies containing different types of sugar and fat, and determine their effect on physiological parameters in diabetic rats. The experimental animals were studied using a randomised block design with seven groups of rats. The test groups were as follows: group 1, negative control rats (normal) fed standard; group 2, positive control rats (diabetic) fed standard; group 3, diabetic rats fed wheat cookies; group 4, diabetic rats fed C1 corn cookies; group 5, diabetic rats fed C2 corn cookies; group 6, diabetic rats fed C3 corn cookies; and group 7, diabetic rats fed C4 corn cookies. The tests on the rats revealed that the cookies had significant effects on blood sugar, malondialdehyde (MDA) and haemoglobin levels as well as body weight parameters. Corn cookies containing crystalline coconut sugar and virgin coconut oil (VCO) were effective at lowering blood sugar and MDA levels while increasing haemoglobin and body weight in diabetic rats. Significantly, after four weeks on this diet, rats with diabetes mellitus were in the same overall condition as normal rats. These findings suggest that these cookies may be gluten-free functional foods suitable for diabetics. These findings suggest that diabetics can safely consume maize cookies.

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Section: Resultsmentioning

confidence: 99%

Blood Sugar, Haemoglobin and Malondialdehyde Levels in Diabetic White Rats Fed a Diet of Corn Flour Cookies

Aini

Sustriawan

Wahyuningsih

et al. 2022

Foods

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show abstract

“…Furthermore, using this extract elevated the activities of plasma insulin, vitamin E, and vitamin C and reduced glutathione (GSH) content when compared with the diabetic control group. A study by Labbaci and Boukortt [ 111 ] indicated that consumption of U. lactuca seaweed and its hydroethanolic extract mitigated insulin resistance, which plays a fundamental role in the pathogenesis of diabetes and helps regenerate damaged pancreatic β-cells. In addition, U. lactuca and its hydroethanolic extract may have anti-atherosclerotic effects by improving reverse cholesterol transport.…”

Section: Treatment Of Diabetesmentioning

confidence: 99%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady

Gheda

Ismail

et al. 2023

Life

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological and nutraceutical applications. Due to lifestyle modifications brought on by rapid urbanization, diabetes mellitus, a metabolic illness, is the third largest cause of death globally. The hunt for an efficient natural-based antidiabetic therapy is crucial to battling diabetes and the associated consequences due to the unfavorable side effects of currently available antidiabetic medications. Finding the possible advantages of algae for the control of diabetes is crucial for the creation of natural drugs. Many of algae’s metabolic processes produce bioactive secondary metabolites, which give algae their diverse chemical and biological features. Numerous studies have demonstrated the antioxidant and antidiabetic benefits of algae, mostly by blocking carbohydrate hydrolyzing enzyme activity, such as α-amylase and α-glucosidase. Additionally, bioactive components from algae can lessen diabetic symptoms in vivo. Therefore, the current review concentrates on the role of various secondary bioactive substances found naturally in algae and their potential as antioxidants and antidiabetic materials, as well as the urgent need to apply these substances in the pharmaceutical industry.

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“…Besides, using this extract elevated the activities of plasma insulin, vitamin E, and vitamin C and reduced glutathione (GSH) when compared with the diabetic control group. A study by Labbaci and Boukortt [113] indicated that consumption of the green alga Ulva lactuca and its hydroethanolic extract mitigate insulin resistance, which plays a fundamental role in the pathogenesis of diabetes and may help regenerate damaged pancreatic β-cells. In addition, U. lactuca and its hydroethanolic extract may have anti-atherosclerotic effects by improving reverse cholesterol transport.…”

Section: In Vivo Antihyperglycemic Activity Of Algaementioning

confidence: 99%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady¹,

Gheda²,

Ismail³

et al. 2022

Preprint

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological, cosmetic, and nutraceutical applications. Many of these bioactive compounds are secondary metabolites whose amounts in the algae vary with varying environmental conditions. Free radicals and other active oxygen derivatives are recognized as a natural by-product of aerobic metabolism. However, reactive oxygen species directly participate in mechanisms related to various pathological states such as cancer, diabetes, atherosclerosis, Alzheimer's, and Parkinson's, among others. Diabetes mellitus (DM) is a metabolic disease resulting from changes in glucose metabolism and/or deficient production/action of insulin. This review has as its main objective to reveal the potential antioxidant and antidiabetic capacity of algae extracts.

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Beneficial Effects of Algerian Green Alga Ulva lactuca and Its Hydroethanolic Extract on Insulin Resistance and Cholesterol Reverse Transport in High-Fat/Streptozotocin Diabetic Rats

Cited by 9 publications

References 53 publications

Blood Sugar, Haemoglobin and Malondialdehyde Levels in Diabetic White Rats Fed a Diet of Corn Flour Cookies

Blood Sugar, Haemoglobin and Malondialdehyde Levels in Diabetic White Rats Fed a Diet of Corn Flour Cookies

Antioxidant and Antidiabetic Activity of Algae

Antioxidant and Antidiabetic Activity of Algae

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