Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats

Bulut, Nuriye Esen; Özkan, Erkan; Ekinci, Osman; Dulundu, Ender; Topaloğlu, Ümit; Şehirli, Ahmet Özer; Ercan, Feríha; Şener, Göksel

doi:10.5505/tjtes.2011.99835

Cited by 19 publications

(11 citation statements)

References 31 publications

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“…33 In this study, plasma amylase (approximately fourfold above control) and lipase (approximately fifteen fold above control) activities in the CER group were significantly higher than the control group; quercetin pre-and post-treatment significantly decreased amylase and lipase activities compared to the CER group.…”

Section: 2122mentioning

confidence: 47%

The effect of quercetin on cerulein-induced acute pancreatitis

Kahraman¹,

Vurmaz²,

Koca³

et al. 2017

Medical Express

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OBJECTIVE:The aim of this study was to evaluate the protective and therapeutic effects of quercetin on pancreatic injury in cerulein-induced acute pancreatitis. METHOD: Thirty-two rats were randomly divided into four groups, eight per group: (CT): untreated controls, (CER) treated with cerulein, 50 μg/kg body weight; (Q+CER) pre-treatment with quercetin, 100 mg/kg body weight, followed by cerulein, 50 μg/kg; (CER+Q) post-treatment, cerulein followed by quercetin, same doses. Cerulein was divided into four doses, given at 1-hour intervals by intraperitoneal injection. Quercetin was given either 1-hour before (in pre-treatment group) or 1-hour after (in post-treatment group) cerulein. Pancreatic malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), reduced and oxidized glutathione (GSH and GSSG, respectively) were measured. Histology of the pancreas was studied. RESULTS: (1) MDA, carbonyl, MPO, TNF-a and IL-6 levels were significantly higher in CER vs CT rats. (2) MDA, carbonyl, MPO and TNF-α decreased significantly in pre-treated rats vs. CER. (3) MDA, MPO, TNF-α, IL-6 were significantly lower in post-treated rats vs. CER. (4) The reduced vs. oxidized glutathione ratio (GSH/GSSG) of was significantly lower CER vs. CT rats. (5) Pre-and post-treatment with quercetin significantly increased this ratio. (6) Pancreatic histology showed that quercetin had no significant effect on the histological image of the pancreas CONCLUSION: These results suggest that quercetin can attenuate the severity of cerulein-induced acute pancreatitis by acting as an antioxidant and anti-inflammatory agent and combating oxidative stress. Further studies are needed to clearly explain its utility on acute pancreatitis.

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Section: 2122mentioning

confidence: 47%

The effect of quercetin on cerulein-induced acute pancreatitis

Kahraman¹,

Vurmaz²,

Koca³

et al. 2017

Medical Express

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“…The sections were stained with haematoxylin and eosin and evaluated under a light microscope to detect inflammatory manifestations, including oedema, leukocyte infiltration, parenchymal necrosis and haemorrhage in the pancreatic tissue. The general morphology and histological features were evaluated with a BX51 photomicroscope (Olympus Corporation, Tokyo, Japan) 20…”

Section: Methodsmentioning

confidence: 99%

Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis

Al-Hariri

Eldin

Hashim

et al. 2019

Sultan Qaboos Univ Med J

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Objectives: This study aimed to determine the effects of propolis on immune mediators and tissue histopathology in rats with L-arginine-induced acute pancreatitis (AP). Methods: This study was conducted at Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2017. A total of 24 male albino Wistar rats were divided into three equal groups. Group one was the negative control, group two was the positive control (L-arginine-induced AP) and group three received treatment (L-arginineinduced AP and propolis). The rats in group three were treated with 100 mg/kg propolis for seven days after AP induction. Pancreatic tissue was evaluated histologically and levels of interleukin (IL)-6, IL-22 and IL-1β and tumour necrosis factor-alpha (TNF-α) were measured. Results: Propolis reduced the quanitity of proinflammatory molecules (TNF-α, IL-1β and IL-6) in group three compared to group two, significantly increased the overall anti-inflammatory effect of IL-22 (P <0.005) and reduced interstitial inflammation and neutrophil cell infiltration of the pancreatic tissues. Conclusion: Propolis may exert a therapeutic effect in AP. Further studies are required to demonstrate the mechanisms of propolis in AP.Keywords: Propolis; Arginine; Pancreatitis; Interleukins; Cytokinesis; Rats; Saudi Arabia.

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“…Alpha‐lipoic acid has also been reported to be effective against conditions in which oxidative stress plays a role . It has also been reported that ALA might be a preventive agent in ulcerogenesis and inflammation‐associated tumor formation .…”

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confidence: 99%

Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats

Şehirli¹,

Aksoy²,

Basmacı³

et al. 2019

European J Oral Sciences

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This study was designed to assess the possible protective effect of alpha‐lipoic acid (ALA) on apical periodontitis (AP)‐induced cardiac injury. Wistar albino rats were randomized into four groups: control; ALA; AP; and ALA + AP. Rats of the control and ALA groups were not endodontically treated, but saline and ALA (100 mg kg−1) were administered. In rats of the AP and ALA + AP groups, the pulp chambers of mandibular first molar teeth were exposed and left open for 30 d to induce AP. Saline and ALA (100 mg kg−1) were administered intraperitoneally every 24 h during the experiment. At the end of the experiment, the rats were killed. Establishment of AP was verified by radiographic and histopathological evaluation. Serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), and superoxide dismutase (SOD) activities were determined using an automated biochemical analyzer, and the structural cardiac injury was assessed pathologically. Serum ALP, LDH, and CK activities were elevated, and SOD activities were decreased, in the AP group. The changed enzyme activities were significantly normalized by treatment with ALA. We conclude that ALA administration alleviated the AP‐induced heart injury and improved cardiac structure and function, and therefore this agent may be of potential therapeutic value in protecting cardiac tissue from systemic injury caused by AP.

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Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats

Cited by 19 publications

References 31 publications

The effect of quercetin on cerulein-induced acute pancreatitis

The effect of quercetin on cerulein-induced acute pancreatitis

Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis

Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats

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