Beneficial effects of &amp;lt;i&amp;gt;Achillea millefolium&amp;lt;/i&amp;gt; aqueos extract against cyclophosphamide-induced reproductive toxicity

Jalali, Ali Shalizar; Hasanzadeh, Shapour; Malekinejad, H

doi:10.5455/jeim.110313.or.061

Cited by 10 publications

(9 citation statements)

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“…The marked reduction in the absolute testis weight in the CP‐exposed animals can be explained by the decrease in the number of germ cells, Leydig cells atrophy and a reduction in the rate of spermatogenesis. In addition, a reduction in accessory gland (androgen‐dependent organs) weights after CP exposure may reflect a reduction in the androgens availability (Jalali et al., ; Katoh et al., ), confirmed after the testosterone dosage.…”

Section: Discussionmentioning

confidence: 98%

“…Despite the great therapeutic importance of the chemotherapeutic agent Cyclophosphamide (CP) (Das, Mallick, Debnath, & Ghosh, ), several reproductive disorders, such as aspermia, oligozoospermia, atrophy of testicular seminiferous tubules and reduction in serum testosterone levels, have been associated with the exposure to this drug (Howell & Shalet, ; Jalali, Hassanzadeh, & Malekinejad, ). Studies have demonstrated that these effects can be caused by the generation of reactive oxygen species (ROS) and lipid peroxidation (Arumugam, Sivakumar, Thanislass, & Devaraj, ; Sulkowska, Sulkowski, Skrzydlewska, & Farbiszewski, ).…”

Section: Introductionmentioning

confidence: 99%

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Acrocomia aculeataoil: Beneficial effects on cyclophosphamide-induced reproductive toxicity in male rats

et al. 2018

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This study aimed to evaluate the effects of the extracted oil of Acrocomia aculeata pulp in preventing or mitigating the reproductive toxicity induced by cyclophosphamide (CP) in male rats. Adult male rats were segregated into seven groups that received vehicle, 100 mg/kg/day of CP, or 10 mg/kg/day of β-carotene or 3 or 30 mg/kg/day of A. aculeata oil co-administered with CP. A. aculeata oil exhibited a high content of β-carotene. CP treatment induced reproductive toxicity in the animals, as it changed the reproductive organs weight, hormone levels, sperm counts and testicular histology. In contrast, co-administration of A. aculeata improved CP-induced alterations in these parameters. A. aculeata oil also increased the gene Ckit expression and normalised the antioxidant enzymes levels which were changed by CP. The A. aculeata oil is capable of protecting the male reproductive system from the adverse effects of CP, possibly by acting as an antioxidant and increasing the Ckit gene expression.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Acrocomia aculeataoil: Beneficial effects on cyclophosphamide-induced reproductive toxicity in male rats

et al. 2018

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“…Therefore, a number of natural products or herbal medicines (El-Alfy et al, 2013;Oh et al, 2007;Premkumar et al, 2001;Shanmugarajan et al, 2008) have been examined for their possible protective or mitigating effects on CYP-induced reproductive toxicity, with variable results. However, despite the fact that a number of plants have shown promise against CYP-induced reproductive system toxicity (Jalali, Hassanzadeh, & Malekinejad, 2011;Nantia, Moundipa, Monsees, & Carreau, 2009;Premkumar et al, 2001Singh et al, 2015, impaired fertility that results from CYP-induced gonadotoxicity still presents a unique challenge.…”

Section: Introductionmentioning

confidence: 99%

Cyclophosphamide-induced male subfertility in mice: An assessment of the potential benefits of Maca supplement

2017

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Effects of Lepidium meyenii (Maca) on cyclophosphamide (CYP)-induced gonadal toxicity in male mice were investigated. Mice were assigned to six treatment groups: Vehicle control, CYP control, CYP plus oral Maca (500 or 1,000 mg/kg), and oral Maca (500 or 1,000 mg/kg). CYP was administered via the intraperitoneal route (days 1-2), while vehicle or Maca were administered daily for 28 days. On day 28, half of the animals in each group were either sacrificed or paired with age-matched females for fertility assessment. Plasma testosterone assay, sperm analysis and assessment of tissue antioxidant/morphological status were also carried out. CYP administration was associated with oxidative stress, subfertility and morphometric/morphological indices of gonadal injury, while administration of Maca mitigated CYP-induced gonadal toxicity and subfertility. This study shows that Maca is beneficial in the mitigation of CYP-induced male gonadal insufficiency and/or testicular morphological changes; however, further studies will be needed to ascertain its usability for this purpose in humans.

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“…In previous studies, AM has been shown to have antioxidant, anti‐inflammatory, antimicrobial and antitumour properties (Candan et al., 2003; Jalali et al., 2012; Lin et al., 2002; Tozyo et al., 1994). AM has also been found to be an important scavenger of active oxygen species, including OH radical, H 2 O 2 and DPPH (Jalali et al., 2013). AM has previously been shown to reduce oxidative damage caused by H 2 O 2 in human erythrocytes and leukocytes, thanks to its flavonoid and phenol content (Konyalioglu & Karamenderes, 2005).…”

Section: Discussionmentioning

confidence: 99%

Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

Okkay

Çiçek

et al. 2021

Andrologia

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The aim of this study was to investigate the effects of Achillea millefolium extract in paclitaxel‐induced testicular toxicity in rats. The groups were designed as (1) control, (2) paclitaxel (8 mg/kg, intraperitoneally), (3) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (200 mg/kg, orally for 14 consecutive days) and (4) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (400 mg/kg, orally for 14 consecutive days). Serum levels of testosterone, luteinising hormone and follicle‐stimulating hormone, as well as total antioxidant capacity and total oxidant status were measured one day after receiving the last dose of Achillea millefolium extract. Testicular superoxide dismutase activity, malondialdehyde, tumour necrosis factor alpha and interleukin‐1β levels, the expressions of nuclear factor kappa B and caspase‐3 were evaluated. In addition, testicular sections were evaluated histopathologically and 8‐hydroxy‐2′‐deoxyguanosine was detected immunohistochemically. Achillea millefolium improved the levels of luteinising hormone, follicle‐stimulating hormone and testosterone, upregulated testicular antioxidant enzymes and downregulated inflammation. Furthermore, we observed that Achillea millefolium restored testicular histopathological structure and significantly suppressed oxidative DNA damage and apoptosis by reducing the expression of caspase‐3. Taken together, our results suggest that Achillea millefolium has protective effects against paclitaxel‐induced testicular toxicity and is a promising natural product with the potential to improve male fertility.

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Beneficial effects of <i>Achillea millefolium</i> aqueos extract against cyclophosphamide-induced reproductive toxicity

Cited by 10 publications

References 0 publications

Acrocomia aculeataoil: Beneficial effects on cyclophosphamide-induced reproductive toxicity in male rats

Acrocomia aculeataoil: Beneficial effects on cyclophosphamide-induced reproductive toxicity in male rats

Cyclophosphamide-induced male subfertility in mice: An assessment of the potential benefits of Maca supplement

Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

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