Beneficial effects of Ankaferd Blood Stopper on dermal wound healing: an experimental study

Akalın, Çağrı; Kuru, Serdar; Barlas, Aziz Mutlu; Kısmet, Kemal; Kaptanoğlu, Buğra; Yorulmaz, Ahu; Astarci, Hesna Muzeyyen; Üstün, Hüseyin; Ertaş, Ertuğrul

doi:10.1111/j.1742-481x.2012.01063.x

Cited by 33 publications

(35 citation statements)

References 25 publications

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“…To our knowledge, this is the only study reporting ABS having a positive effect on wound healing. [31] The effects of ABS on different tissues and healing has been studied previously. [5,6,10] Okumuş et al [5] investigated the basic histopathological changes under a light microscope in deep tissue injuries as well as remote organs such as brain, heart, kidney, and liver, when ABS was applied on the punctured femoral vein region in rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ankaferd blood stopper® on tendon healing: an experimental study in a rat model of Achilles tendon injury

Aydın

Altan

Acar

et al. 2015

Eklem Hastalik Cerrahisi

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Section: Discussionmentioning

confidence: 99%

Effect of Ankaferd blood stopper® on tendon healing: an experimental study in a rat model of Achilles tendon injury

Aydın

Altan

Acar

et al. 2015

Eklem Hastalik Cerrahisi

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“…ABS has been used as a local haemostatic agent in surgery, but it was also shown to promote healing (5,9). Its effects on soft-tissue healing have been investigated (17,(19)(20)(21), but not in a STZ model of diabetes. Therefore, the aim of the present study was to histologically assess the effects of ABS on collagen 4, blood GSH levels, and LPO to evaluate its potential effects in early-stage soft-tissue healing on STZtreated rats.…”

Section: Discussionmentioning

confidence: 99%

“…Collagen, which is beneficial for endoepidermal growth and therefore healing, is a major functional extracellular matrix protein in the dermal layer of the skin (20). Collagen 4, VEGF, and TGF-β are commonly used markers of healing potential (24,26,27,(30)(31)(32) and were evaluated in this study as well.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Ankaferd BloodStopper on dermal healing in diabetic rats

Aktop¹,

Çevreli²,

Genç³

et al. 2017

Turk J Med Sci

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IntroductionDiabetes mellitus (DM) is a chronic, life-long metabolic disease occurring worldwide. Affected individuals require continuous follow-up and suffer numerous disease-related complications. The high levels of blood glucose that characterise DM contribute to an increase in free radical production, enhanced oxidative stress, and changes in antioxidant capacity (1-3).Streptozotocin (STZ) is the chemical agent most frequently used to induce experimental diabetes in animal models. By binding to glucose receptors in the plasma membrane, STZ blocks glucose-induced insulin secretion (2,3) and alters blood insulin and glucose concentrations.Among the many effects of free radical production is lipid peroxidation (LPO). Oxidation of membrane polyunsaturated fatty acids disrupts cell structure and function and induces cytotoxic, hepatotoxic, mutagenic, and genotoxic effects related to the release of aldehydes (4,5).The tripeptide glutathione (GSH) is found in the cells of all organisms. In humans, GSH concentrations are highest in the liver; in hepatocytes, GSH accounts for 90% of nonprotein sulfhydryl groups. As an important reducing agent and antioxidant, GSH maintains the cellular oxidoreduction balance and protects cells against the toxic effects of oxidants, whether of endogenous or exogenous origin (5-7).Ankaferd BloodStopper (ABS) (Ankaferd Health Products Ltd., İstanbul, Turkey) is a medicinal extract from the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica (7,8). ABS is not only an effective haemostatic agent but also Background/aim: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats. Materials and methods:The 24 Wistar albino rats used in this study were divided into STZ-treated (STZ, n = 12) and nontreated groups (control, n = 12). Four days prior to surgery, rats in the STZ group were subcutaneously administered 60 mg/kg STZ intraperitoneally, while rats in the control group were administered 1 mL saline/kg. An incision was made in the dorsal dermal tissue of all rats, and either ABS or no haemostatic agent (NHAA) was applied to the wound before suturing. All of the rats were euthanised on postoperative day 4. Blood and skin samples were evaluated biochemically and histologically. Results:The results showed that STZ treatment impaired soft-tissue healing, assessed by measuring glutathione and lipid peroxidation levels. Moreover, while good histological results were obtained in the control group treated with ABS, there were fewer benefits in the STZ-treated group. Conclusion:AB...

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“…Few studies have been published evaluating the effect of ABS, which seems to be an effective hemostatic agent, on wound healing [14,15] . Isler et al [14] investigated the effects of ABS on early bone healing using a rat tibia defect model.…”

Section: Introductionmentioning

confidence: 99%

Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi: Deneysel Çalışma

Satar¹,

Cangül²,

Topal³

et al. 2014

Kafkas Univ Vet Fak Derg

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We investigated the effects of Ankaferd Blood Stopper (ABS) and tripeptide copper complex (TCC) on wound healing in rats. A total of 24 outbred, male, Sprague-Dawley rats were randomly divided into (1) ABS, (2) TCC, and (3) control groups. Bilateral experimental wounds were created near the caudal border of the scapula. Each wound in the respective treatment group was treated daily with sponges soaked in ABS solution, topical TCC gel, or saline. On days 0, 7, 14 and 21, unhealed wound area was measured and biopsy samples were taken for histopathological analysis (except day 0). Median time for the first observable granulation tissue was not significantly different in the ABS, TCC, and control groups (5.8, 5.5, and 6.7 days, respectively) (P>0.05). Filling of the open wound with granulation tissue to skin level was significantly slower in the control group than in the ABS and TCC groups (18, 9, and 11 days, respectively). The mean unhealed wound area was significantly smaller and the mean percentage of total wound healing was significantly higher in the ABS-and TCC-treated wounds than in the control wounds on day 7, 14, and 21 (P<0.05); the average time for healing was also significantly shorter in the treatment groups than in the control group (17.4, 16.8 vs. 23.6 days, respectively) (P<0.05). Our results suggest that topical application of ABS and TCC have beneficial effects on wound healing. Keywords: Wound healing, Ankaferd Blood Stopper (ABS), Tripeptide copper complex (TCC), Skin, Rat Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi:Deneysel Çalışma ÖzetBu çalışmada, Ankaferd Blood Stopper (ABS) ve tripeptid bakır kompleksinin (TCC) ratlarda yara iyileşmesi üzerine etkilerinin araştırılması amaçlanmıştır. Sprague-Dawley ırkı, dişi, 24 adet rat, rastgele şekilde 1) ABS, 2) TCC, ve 3) Kontrol olmak üzere 3 gruba ayrıldı. Skapulanın kaudal sınırına yakın sahada bilateral deneysel yaralar oluşturuldu. Her bir yara günlük olarak grubuna göre ABS solüsyon emdirilmiş sponjlar, topikal TCC jel ya da serum fizyolojik ile tedavi edildi. İyileşmemiş yara alanı 0, 7, 14 ve 21. günlerde ölçüldü ve histopatolojik analiz için biyopsi örnekleri alındı (0. gün haricinde). İlk gözlenebilir granulasyon dokusu oluşumu ortalama zamanı açısından ABS, TCC ve kontrol grupları arasında anlamlı istatistiki fark yoktu (sırasıyla 5.8, 5.5 ve 6.7 gün) (P>0.05). Açık yara sahasının deri düzeyine kadar granulasyon dokusu ile dolma süresi, kontrol grubunda ABS ve TCC grubundan anlamlı şekilde daha düşüktü (sırasıyla 18, 9 ve 11 gün). ABS ve TCC ile tedavi edilen yaraların 7, 14 ve 21. günlerde yapılan ölçümlerinde ortalama iyileşmemiş yara sahasının kontrol grubuna kıyasla anlamlı şekilde daha küçük ve ortalama total yara iyileşme yüzdesinin kontrol grubuna göre anlamlı şekilde daha büyük olduğu gözlendi (P<0.05); ortalama iyileşme zamanı da uygulama yapılan gruplarda kontrol grubundan anlamlı şekilde daha kısa (sırasıyla 17.4, 16.8 ve 23.6 gün) (P<0.05) olarak bulundu. Eld...

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Beneficial effects of Ankaferd Blood Stopper on dermal wound healing: an experimental study

Cited by 33 publications

References 25 publications

Effect of Ankaferd blood stopper® on tendon healing: an experimental study in a rat model of Achilles tendon injury

Effect of Ankaferd blood stopper® on tendon healing: an experimental study in a rat model of Achilles tendon injury

Effects of Ankaferd BloodStopper on dermal healing in diabetic rats

Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi: Deneysel Çalışma

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