Beneficial effects of aqueous extract of stem bark of Terminalia arjuna (Roxb.), An ayurvedic drug in experimental pulmonary hypertension

Meghwani, Himanshu; Prabhakar, Pankaj; Mohammed, Soheb Anwar; Seth, Sandeep; Hote, Milind Padmakar; Banerjee, Sanjay K.; Arava, Sudheer; Ray, Ruma; Maulik, Subir Kumar

doi:10.1016/j.jep.2016.07.029

Cited by 31 publications

(16 citation statements)

References 45 publications

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“…Studies done in our laboratory have shown that the bark extract of TA has beneficial effects in experimentally induced myocardial ischemia, hypertrophy, fibrosis, and other cardiovascular disorders. It boosts anti-oxidant activities, prevents fibrosis, protects against ischemia reperfusion injury and has anti-hypotensive effects (Kumar et al, 2009;Maulik and Katiyar, 2010;Maulik et al, 2016;Meghwani et al, 2017). In a recent study, arjunolic acid, one of the constituents of the aqueous TA extract, was shown to ameliorate cardiac fibrosis by inhibiting TGF-β signaling (Bansal et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Validation of the Protective Effects of Aqueous Bark Extract of Terminalia arjuna (Roxb.) on Isoproterenol-Induced Cardiac Hypertrophy in Rats

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Transcriptomic Validation of the Protective Effects of Aqueous Bark Extract of Terminalia arjuna (Roxb.) on Isoproterenol-Induced Cardiac Hypertrophy in Rats

et al. 2019

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“…b. Antioxidant: Plant extracts and phytochemicals with antioxidant properties on treatment of PH include B. vulgaris, C. rhipidophylla, K. odoratissima, M. oleifera, T. arjuna, T. pratense, carvacrol, magnesium lithospemate B, oxymatrine and resveratrol, which do their effect by increasing CAT, SOD, GPx, GSH levels and reducing H 2 O 2 , ROS, and MDA levels. All of these indicators show decrease oxidative stress and reduce tissue damage (Chen et al, 2012;Ahmadipour et al, 2015;Kaur et al, 2015;Jiang and Yang, 2016;Xu et al, 2016;Zhang et al, 2016;Guan et al, 2017;Meghwani et al, 2017;Ahmadipour et al, 2019). c. Antivascular remodeling: Vascular remodeling is one of the important events during PH progression that has been explained before.…”

Section: Discussionmentioning

confidence: 97%

“…They act by inhibiting of growth factors such as TGF-b1, AhR and HIF-1a or suppressing PI3K/ACT, ERK1/2/STAT3 pathways, or increase the expression of BAX and caspase-3 (apoptosis inducers) and decrease the expression of BCL2 (anti-apoptosis factor). All of these agents drive the cells (lung tissue cells, PAECs and PASMCs) toward apoptosis and inhibit the progression of PH (Guo et al, 2014;Huang et al, 2014;Kaur et al, 2015;He et al, 2015;Zhang et al, 2016;Guan et al, 2017;Meghwani et al, 2017;Hua et al, 2018). f. Anti-inflammation: One of the notable processes in PH is increased inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Some of the pharmacological activities of T. arjuna are antiischemic, antioxidant, hypolipidemi, increasing cardiac contraction and decreasing blood pressure, (Pawar and Bhutani, 2005;Kapoor et al, 2014). Meghwani et al (2017) found that the aqueous extract of T. arjuna stem bark can prevent the decrease of relative weight of lungs in pulmonary hypertensive rats. The study was performed on MCT-induced PH rats.…”

Section: Salvia Miltiorrhiza Bungementioning

confidence: 99%

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Medicinal Plants and Phytochemicals for the Treatment of Pulmonary Hypertension

et al. 2020

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Background: Pulmonary hypertension (PH) is a progressive disease that is associated with pulmonary arteries remodeling, right ventricle hypertrophy, right ventricular failure and finally death. The present study aims to review the medicinal plants and phytochemicals used for PH treatment in the period of 1994-2019. Methods: PubMed, Cochrane and Scopus were searched based on pulmonary hypertension, plant and phytochemical keywords from August 23, 2019. All articles that matched the study based on title and abstract were collected, non-English, repetitive and review studies were excluded. Results: Finally 41 studies remained from a total of 1290. The results show that many chemical treatments considered to this disease are ineffective in the long period because they have a controlling role, not a therapeutic one. On the other hand, plants and phytochemicals could be more effective due to their action on many mechanisms that cause the progression of PH. Conclusion: Studies have shown that herbs and phytochemicals used to treat PH do their effects from six mechanisms. These mechanisms include antiproliferative, antioxidant, antivascular remodeling, anti-inflammatory, vasodilatory and apoptosis inducing actions. According to the present study, many of these medicinal plants and phytochemicals can have effects that are more therapeutic than chemical drugs if used appropriately.

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“…Traditional chines medicine San‐Huang‐Xie‐Xin‐Tang has also reported the potent PDE‐5, Rho‐Kinase and cyclooxygenase‐2 inhibitor which reflect the novel notion for the treatment of PH (Liou et al, ). Moreover, widely documented Terminalia Arjuna (Combretaceae) and Punicalagin (Punica granatum) have found to reduce the right ventricular hypertrophy and systolic pressure, that are the root cause of PH (Meghwani et al, ). Punicalagin has also been explored for its therapeutic effect on PH through upregulation of No/cGMP signaling pathways and downregulation of oxidative stress (Shao et al, ).…”

Section: Pharmacological Interventions and Their Molecular Aspectsmentioning

confidence: 99%

Pulmonary hypertension: Molecular aspects of current therapeutic intervention and future direction

Arora

Sachdeva³

et al. 2017

Journal Cellular Physiology

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Pulmonary hypertension (PH) is a life-threatening lung disorder with towering prevalence and risk for future has been gradually rising worldwide. Even, no specific medications are available for pulmonary hypertension; various classes of treatment based upon the origin and magnitude of hypertension are still used for the treatment of PH. Consideration of molecular or signaling modulation is the imperative approach that can offer a new notion for prevalent pharmacotherapeutic agents. Instead of concurrent targets, including endothelin receptor antagonists (ETA/ETB), phosphodiesterase 5 inhibitor (PDF-5), calcium channel blockers, anticoagulants, diuretics, and long acting prostacyclin analog, recent scientific reports revealed the numerous potential alternative therapeutic approaches that can significantly target the pathological signaling alteration associated with PH. Understanding precise molecular cascade involved in PH can be useful for designing preclinical animal experiments and human clinical trials to evaluate target specific novel therapeutic interventions for the treatment of PH. In this review, we discussed the possible molecular signaling involved in the pathogenesis of PH and detailed account of the current status of medications employed for the treatment of PH. Moreover, the newly identified potential target sites and alternative approaches for treating the PH have been discussed.

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Beneficial effects of aqueous extract of stem bark of Terminalia arjuna (Roxb.), An ayurvedic drug in experimental pulmonary hypertension

Cited by 31 publications

References 45 publications

Transcriptomic Validation of the Protective Effects of Aqueous Bark Extract of Terminalia arjuna (Roxb.) on Isoproterenol-Induced Cardiac Hypertrophy in Rats

Transcriptomic Validation of the Protective Effects of Aqueous Bark Extract of Terminalia arjuna (Roxb.) on Isoproterenol-Induced Cardiac Hypertrophy in Rats

Medicinal Plants and Phytochemicals for the Treatment of Pulmonary Hypertension

Pulmonary hypertension: Molecular aspects of current therapeutic intervention and future direction

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