With the continuous improvement of people's economic level and the maturity of consumption concepts, natural cosmeceuticals (with therapeutic effects) have received more and more attention, which has prompted the innovative development of the cosmeceuticals industry. Natural ingredients derived from plants and the marine have attracted the attention of scientists for their sustainability and less skin irritation. These ingredients, along with low skin penetration and instability, influence formulation development. Nanotechnology is used to help improve the shortcomings of natural ingredients such as instability in formulations. However, the toxicity of nanotechnology and regulatory gaps have also raised concerns and potential concerns among consumers. This paper provides an overview of potential active ingredients in botanical and marine cosmeceuticals and how they can improve formulation innovation under the action of different nano delivery systems. Relevant literature from pub med, web of science, and other websites are studied to corroborate the most recent trends in the development of cosmeceuticals and the most recent advancements in industry regulation. As a result, a key area of research for scientists continues to be how to enhance formulations while creating natural nano-cosmeceuticals to allay consumers' worries about toxicity.