Beneficial effects of creatine phosphate sodium for the treatment of Henoch–Schönlein purpura in patients with early renal damage detected using urinary kidney injury molecule-1 levels

Abstract

Our results suggest that the urinary KIM-1 level is a sensitive and specific biomarker for the detection of early renal damage in HSP and may predict the severity of HSP and HSPN. The administration of creatine phosphate sodium (CP) may reduce urinary KIM-1 levels and thus correct the hypoxic condition of the kidney. Preconditioning with CP may also be a useful adjunct for preventing early renal damage in HSPN patients.

Analysis of the association between kidney injury biomarkers concentration and nephritis in immunoglobulin A vasculitis: A pediatric cohort study

“…In the present study we have not demonstrated any correlation between serum and urine concentrations of KIM‐1 and nephritis. Unlike our conclusions, Zhang et al and Zhang and colleagues confirmed the diagnostic value of urinary KIM‐1 for detecting kidney injury in IgAV patients 8,9 . In the first study conducted on children, urinary KIM‐1 levels were considerably higher in the IgAV‐N group than in the IgAV‐noN group.…”

“…Unlike our conclusions, Zhang et al and Zhang and colleagues confirmed the diagnostic value of urinary KIM-1 for detecting kidney injury in IgAV patients. 8,9 In the first study conducted on children, urinary KIM-1 levels were considerably higher in the IgAV-N group than in the IgAV-noN group. Moreover, they manifested a positive correlation with total urinary protein and histopathological grade assessed in accordance with International Study for Kidney Disease in Children classification.…”

“…Moreover, they manifested a positive correlation with total urinary protein and histopathological grade assessed in accordance with International Study for Kidney Disease in Children classification. 8 In the second research conducted on adult IgAV patients, concentrations of KIM-1 in urine were associated with interstitial inflammation, tubulointerstitial chronicity TA B L E 4 Logistic regression analysis in univariate model of the association of clinical characteristics, selected biochemical parameters, concentration of examined biomarkers and renal involvement in the course of immunoglobulin A vasculitis and extracapillary glomerular activity indices, which allowed the authors to conclude that the measurement of urinary KIM-1 level might be contributory in the evaluation of the severity and progression of renal damage in patients with IgAV-N. 9 Du et al have gone a step further in their analysis, indicating that the expression of NGAL and KIM-1 in serum, urine and renal tissues of children with IgAV-N and coexisting AKI was significantly higher than in the group with IgAV-N and nephrotic-range proteinuria. 10 This research also implied that urine NGAL and KIM-1 concentrations were negatively correlated with eGFR.…”

“…Encouraged by recently published promising reports presenting the value of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in distinguishing patients with IgAVN [6][7][8][9][10] as well as manuscripts on the role of the liver-fatty acid binding protein (L-FABP) as a novel biomarker of kidney injury, [11][12][13] we decided to evaluate their concentrations in children with IgAV.…”

A systematic review of urine biomarkers in children with IgA vasculitis nephritis

“…The participants comprised 1236 children with IgAV-N (48% male, median age 8.0 years), 761 healthy paediatric controls (52% male, median age 7.9 years) and 449 children with IgAV-noN (52% male, median age 7.0 years). The publication dates spanned from 2011-2020 [13,14,17,27] and included both longitudinal [13,17,18,24,28,29] and cross-sectional studies [12,14,15,19,22,23,27]. The majority of the papers were published from China [12, 14, 17, 18, 22-24, 27, 28, 30], and three studies were from Poland [13], France [19] and Mexico [15].…”