Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat–fed hamsters

Jang, Eun-Mi; Choi, Myung‐Sook; Jung, Un Ju; Kim, Myung‐Joo; Kim, Hye-Jin; Jeon, Seon-Min; Shin, Su‐Kyung; Seong, Chi Nam; Lee, Mi-Kyung

doi:10.1016/j.metabol.2008.06.014

Cited by 230 publications

(177 citation statements)

References 53 publications

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“…The present study showed that these particular genes might regulate energy metabolism in the HepG2 cells. Other natural products have been used to examine lipid lowering effects, such as hesperidin, naringin (Jung et al, 2006), resveratrol (Do et al, 2008), and curcumin (Jang et al, 2008), which could also decrease hepatic HMG-CoAR. In contrast, red wine polyphenols (Pal et al, 2003) and anthocyanins in black sticky rice (Sangkitikomol et al, 2010) have been shown to increase hepatic LDLR.…”

Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells

Sangkitikomol¹,

Rocejanasaroj²,

Tencomnao³

2014

Genet. Mol. Res.

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ABSTRACT. In Thai traditional medicine, Moringa oleifera is used for the treatment of diabetes and hyperlipidemia. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases, such as hyperlipidemia, diabetes mellitus, and cardiovascular disease. We evaluated the antioxidant effect of M. oleifera extract (MOE) for reduction of advanced glycation end-product (AGE) formation, cell viability, oxidative stress, and lipid metabolism gene expression in HepG2 cells. We found that the lyophilized form of MOE in 80% ethanol possessed mean (± SD) total antioxidant, polyphenolic, and flavonoid contents of 9307 ± 364 TE mM/kg dry mass, 218 ± 1 GE mM/kg dry mass, and 286 ±12 QE mM/kg dry mass, determined using an oxygen radical absorbance capacity assay, a Folin Ciocalteu phenol assay, and a total flavonoids assay, respectively. Concentrations of 2.5-10.0 mg/ mL MOE could inhibit AGE-formation by 10-45%, and 100-1000 mg/L MOE reduced intracellular oxidative stress (P < 0.05) in a dose-dependent manner in the DCFH-DA assay. However, MOE induced cytotoxicity at high doses (2000-3000 mg/L), as shown by the MTT assay. MOE significantly downregulated the mRNA expression of the HMG-CoAR, PPARα1, and PPARγ genes (P < 0.05). We concluded that M. oleifera could have benefits for human health by reducing oxidative stress and AGE formation. Moreover, M. oleifera may reduce cholesterol and lipid synthesis by suppression of HMG-CoAR, PPARα1, and PPARγ gene expression, thereby maintaining lipid homeostasis.

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Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells

Sangkitikomol¹,

Rocejanasaroj²,

Tencomnao³

2014

Genet. Mol. Res.

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“…The LA compound sinapinic acid had not been reported yet for antidyslipidemic or hypolipidemic activity. Besides this, well known antiadipogenic compounds such as curcumin ( 46 ), cordycepin ( 39 ), berberine ( 53 ), piceatannol ( 43 ) and daidzein ( 54 ) also showed antidyslipidemic and hypolipidemic activity in a hamster model ( 51,(55)(56)(57)(58). Most of the studies were conducted using the Syrian golden hamster because it is a very sensitive model system for changes in lipid profi le when fed with HFD.…”

Section: Discussionmentioning

confidence: 99%

Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo

Varshney

Shankar

Beg

et al. 2014

Journal of Lipid Research

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“…In hypothalamus, leptin stimulates anorexigenic pathways and decrease food intake [60]. It is generally known that most obese animals exhibit high serum leptin concentrations [61].…”

Section: Citationmentioning

confidence: 99%

Methanolic Extract of Clinacanthus nutans Leaves can Alter Adipocyte Cellularity, Inflammation and Acetyl Cholinesterase Activity in Male Obese Mice

Sj¹,

Ebrahimi²,

Y³

et al. 2017

J Obes Weight Loss Ther

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Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat–fed hamsters

Cited by 230 publications

References 53 publications

Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells

Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells

Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo

Methanolic Extract of Clinacanthus nutans Leaves can Alter Adipocyte Cellularity, Inflammation and Acetyl Cholinesterase Activity in Male Obese Mice

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