Beneficial effects of dietary polyphenols using lung inflammation as a model

In focus: Polyphenolics: anti‐inflammatory metabolites underlie health benefits

“…Rahman5 suggests that lung inflammation would be a good model system to study the effects of polyphenolics because lung tissue has much activity in the systems that polyphenolics appear to affect, for example the signaling substance TNF‐α, but also cell signaling processes, such as antioxidant response elements (ARE) pathways. These observations, and many others, lead to the conclusion that a mechanistic understanding of polyphenols probably lies in a better grasp on their effect on the inflammatory process, which itself is only becoming clearer at the present time.…”