2023
DOI: 10.1111/micc.12825
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Beneficial effects of empagliflozin and liraglutide on the cerebral microcirculation of diabetic rats

Joana Costa d'Avila,
Aluana Santana Carlos,
Raimundo Lima Vieira
et al.

Abstract: ObjectivesThis study aimed to evaluate the effects of the antidiabetics liraglutide, a GLP‐1 analog, and empagliflozin, an SGLT‐2 inhibitor, on the brain microcirculation of diabetic rats.MethodsType 2 diabetes mellitus (DM) was experimentally induced in male Wistar rats by combining a high‐fat diet and a low dose of streptozotocin (35 mg/kg). Liraglutide (100 μg/kg s.c.) and empagliflozin (10 mg/kg, oral) were administered for 5 weeks. Body weight was monitored periodically. Oral glucose tolerance, fasting gl… Show more

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