Beneficial effects of estrogens in obstructive sleep apnea hypopnea syndrome

Zhang, Lixiu; Ou, Xiyan; Zhu, Tonggang; Xiaohong, Lv

doi:10.1007/s11325-019-01896-2

Cited by 20 publications

(15 citation statements)

References 33 publications

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“…While there are no other population-based epidemiological studies on our evaluated associations, our observed results are in line with existing small clinical and pre-clinical studies, indicating a protective effect of female sex hormones [ 17 – 19 , 27 , 28 ] Estrogens have been found to play a role in a diverse set of physiological processes and metabolism, not only limited to female reproductive health and behavior. Both high and low levels of estrogens have been linked to various diseases including those of autoimmune, metabolic and neural nature [ 29 ].…”

Section: Discussionsupporting

confidence: 90%

“…The role of estradiol is well established in the development of muscles in the upper respiratory tract [ 15 ] as well as a determinant of fat distribution [ 16 ], which are both plausible mechanisms where low levels of estrogens could predispose women to report OSA symptoms. That low levels of estrogens are associated with decreased odds of symptoms of OSA is also in line with recent findings indicating that estradiol may mitigate the effects of sleep apnea [ 13 , 14 ] Estradiol has been shown to have an antioxidant effect [ 28 ]. It increases the levels of thioredoxin, a protein with antioxidant properties, and moderates the expression of HIF-1α (Hypoxia Induced Factor).…”

Section: Discussionsupporting

confidence: 84%

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Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort

et al. 2022

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Background The prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based study. Objective To investigate whether serum concentration of estrogens and progesterone are associated with the prevalence of sleep apnea symptoms in middle-aged women of the general population. Methods We analyzed data from 774 women (40–67 years) from 15 study centers in seven countries participating in the second follow-up of the European Community Respiratory Health Survey (2010–2012). Multiple logistic regression models were fitted with self-reported symptoms of sleep apnea as outcomes and serum concentrations of various estrogens and progesterone as predictors. All analyses were adjusted for relevant covariates including age, BMI, education, study center, smoking habits, and reproductive age. Results Among all included women, a doubling of serum concentrations of estrone and progesterone was associated with 19% respectively 9% decreased odds of snoring. Among snorers, a doubling of the concentrations of 17β-estradiol, estrone and estrone 3-sulfate was associated with 18%, 23% and 17% decreased odds of breathing irregularly, and a doubling of the progesterone concentration was further associated with 12% decreased odds of waking up suddenly with a chocking sensation. Other evaluated associations were not statistically significant. Conclusions Middle-aged women with low serum estrogen and progesterone levels are more likely to snore and report symptoms of obstructive sleep apnea.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 84%

Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort

et al. 2022

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“…Notably, treatment in vivo with GM showed significant decreased total antioxidant capacity and significant elevated lipid peroxides (MDA), iNOS and NO levels, which are markers of oxidative stress.Pretreatment with oxymatrine strongly diminished these adverse oxidative/nitrative changes, indicating that oxymatrine was administered by intraperitoneal injection had a nephroprotective effect (Table 2). Nuclear respiratory factor 2 (Nrf2) is a transcription factor is an important transcriptional factor which can reduce the oxidative stress by increasing antioxidant defense [22]. In our study, we found that oxymatrine treatment increased the nuclear factor (erythroid-derived-2)-like 2 (Nrf2) and its downstream targets HO-1 mRNA expression.…”

Section: Histological Examinationmentioning

confidence: 62%

Oxymatrine Reverses Gentamicin-Induced Nephrotoxicity via Ameliorating the Immune Response for Gentamicin Therapy

Kang

Gao

Lang

et al. 2020

Preprint

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Background: The aminoglycoside antibiotic gentamicin (GM) is widely used to fight infections caused by Gram-positive and Gram-negative aerobic bacteria. However, its clinical application is limited by serious side effects. Based on this, this study aims to screen drugs that have protective effects on gentamicin-induced kidney injury. Methods : After screening a series of candidate compounds, we found that a natural quinoline alkaloid-oxymatrine showed well protective effects on GM-induced kidney injury. We used gentamicin (100 mg/ kg/d, 7 days) treatment to establish a rat model of kidney injury, and set up control groups and oxymatrine-pretreatment groups to study the protective effect of oxymatrine on kidney injury.Methods: After screening a series of candidate compounds, we found that a natural quinoline alkaloid-oxymatrine showed well protective effects on GM-induced kidney injury. We used gentamicin (100 mg/ kg/d, 7 days) treatment to establish a rat model of kidney injury, and set up control groups and oxymatrine-pretreatment groups to study the protective effect of oxymatrine on kidney injury.Results: The results indicated that Gentamicin treatment of normal rats produced marked renal damage and resulted in significant elevation of blood urea nitrogen and creatinine, as well as N-acetyl-β-D-glucosaminidase. Oxymatrine co-administration could decrease levels of IL-1β, IL-6, and TNF-α (All P <0.01 or P <0.001), as well as N-acetyl-β-D-glucosaminidase. In addition, oxymatrine treatment significantly reduced the expression of Bax and NF-κB mRNA in the kidney (both P <0.01), and increased the expression of Bcl-2, Nrf2 and HO-1 mRNA.Conclusions: The results demonstrate that oxymatrine down-regulates the inflammatory response and reduces the apoptosis by activating antioxidant defense, thereby reducing gentamicin-induced nephrotoxicity.

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“…Obstructive sleep apnea/hypopnea syndrome (OSAHS) is the most common type of apnea (1). It is characterized by recurrent episodes of partial or complete upper airway collapse during sleep (2).…”

Section: Introductionmentioning

confidence: 99%

LncRNA XIST promotes inflammation by downregulating GRα expression in the adenoids of children with OSAHS

Zhou

et al. 2021

Exp Ther Med

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Whether glucocorticoid receptor α (GRα) serves a role in obstructive sleep apnea/hypopnea syndrome (OSAHS) remains unclear. However, it has been reported that GRα expression is decreased in the adenoids of patients with OSAHS. The present study aimed to evaluate the role of GRα in OSAHS and the underlying mechanism. Bioinformatics assays revealed that long noncoding RNA (lncRNA) X inactivate-specific transcript (XIST) was closely associated with GRα. Furthermore, reverse transcription-quantitative PCR showed that the expression of lncRNA XIST was significantly increased in the adenoids of patients with OSAHS compared with healthy controls. Further in vitro studies by Pearson correlation analysis, RNA pull-down assay, western blot analysis and ELISA demonstrated that XIST significantly decreased the expression of GRα and that significantly increased the production of inflammatory cytokines, including interleukin (IL)-8, tumor necrosis factor α, IL-6 and IL-1β, while the overexpression of GRα significantly decreased the production of these inflammatory cytokines in NP69 cells, a human nasopharyngeal epithelial cell line. Furthermore, XIST significantly increased the protein levels of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) subunits, including Rel-B, c-Rel, P52, P50 and P65, which are associated with the transcription of cytokines. The stimulatory effect of XIST was significantly inhibited by the NF-κB inhibitor EVP4593. These results indicated that the stimulatory effect of XIST was dependent on NF-κB. In summary, the present study demonstrated that the XIST-GRα-NF-κB signaling pathway contributed to inflammation in the adenoids of patients with OSAHS.

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Beneficial effects of estrogens in obstructive sleep apnea hypopnea syndrome

Cited by 20 publications

References 33 publications

Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort

Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort

Oxymatrine Reverses Gentamicin-Induced Nephrotoxicity via Ameliorating the Immune Response for Gentamicin Therapy

LncRNA XIST promotes inflammation by downregulating GRα expression in the adenoids of children with OSAHS

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