Beneficial Effects of Exercise on Growth of Rats During Intermittent Fasting

Sakamoto, Kazuko; Grunewald, Katharine K.

doi:10.1093/jn/117.2.390

Cited by 22 publications

(13 citation statements)

References 25 publications

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“…1). As previously reported (Sakamoto and Grunewald, 1987), the Exe/EODF group showed significantly greater body weight gain compared to EODF animals alone (1.045 6 0.11 g/day vs. 0.438 6 0.09 g/ day, respectively, P < 0.05). However, no significant difference in body weight gain was observed between Exe and Sed groups (3.11 6 0.28 g/day vs. 3.5 6 0.21 g/day, respectively, P > 0.05, Fig.…”

Section: Resultssupporting

confidence: 85%

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Khabour¹,

Alzoubi²,

Alomari³

et al. 2009

Hippocampus

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Substantial data suggest that cognitive function can be influenced by many lifestyle activities associated with changes in energy metabolism such as exercise and diet. In the current study, we investigated the combined effects of voluntary exercise (access to running wheels) and dietary restriction (every other day fasting, EODF) on spatial memory formation and on the levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of Wistar male rats. Spatial learning and memory formation was assessed using the radial arm water maze (RAWM) paradigm, while BDNF protein was measured using ELISA test. Voluntary exercise and/or EODF were instituted for 6 weeks. Voluntary exercise alone significantly enhanced short-term, intermediate-term, and long-term memory formation, and increased BDNF protein levels in the hippocampus. EODF enhanced mean running wheel activity by approximately twofold. However, EODF did not modulate the effects of exercise on memory formation and expression of BDNF. In addition, EODF alone had no effect on memory and BDNF protein in the hippocampus. In conclusion, results of this study indicate that exercise enhanced while EODF had neutral effect on both spatial memory formation and hippocampus BDNF levels.

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Section: Resultssupporting

confidence: 85%

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Khabour¹,

Alzoubi²,

Alomari³

et al. 2009

Hippocampus

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“…Studies of exercise and feed efficiency in the rat have yielded varying results ranging from decreases in feed efficiency with exercise (35) to significant improvements in feed efficiency (50). Interpretation of these studies is complicated by the use of varying types and amounts of exercise, strains and ages of rats, diets, and experimental conditions.…”

Section: Discussionmentioning

confidence: 99%

Short-term voluntary exercise in the rat causes bone modeling without initiating a physiological stress response

Rosa¹,

Firth²,

Blair³

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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research has revealed a neuroendocrine connection between the skeleton and metabolism. Exercise alters both bone modeling and energy balance and may be useful in further developing our understanding of this complex interplay. However, research in this field requires an animal model of exercise that does not cause a physiological stress response in the exercised subjects. In this study, we develop a model of short-term voluntary exercise in the female rat that causes bone modeling without causing stress. Rats were randomly assigned to one of three age-matched groups: control, tower climbing, and squat exercise (rising to an erect bipedal stance). Exercise for 21 days resulted in bone modeling as assessed by peripheral quantitative computed tomography. Fecal corticosterone output was used to assess physiological stress at three time points during the study (preexercise, early exercise, and late in the exercise period). There were no differences in fecal corticosterone levels between groups or time points. This model of voluntary exercise in the rat will be useful for future studies of the influence of exercise on the relationship between skeletal and metabolic health and may be appropriate for investigation of the developmental origins of those effects. computed tomography; corticosterone; exercise; metabolism; stress RECENT ADVANCES IN OUR UNDERSTANDING of the dynamic relationship between body structure and metabolism have revealed a neuroendocrine connection between bone remodeling and energy balance, with both bone and fat acting as endocrine organs (14). The osteoblast-specific protein osteocalcin regulates glucose handling through effects on insulin secretion and sensitivity (33). This action is in turn mediated by the adipokine leptin, which inhibits insulin secretion through direct effects on pancreatic ␤-cells (18) and through inhibition of osteocalcin activity (25). The interplay between bone and metabolism has recently been further elucidated by the discovery that the Forkhead family transcription factor FoxO1, a key regulator of insulin handling in multiple tissues, also acts within the osteoblast to control osteocalcin expression and bioactivity (46).Exercise stimulates modeling of the musculoskeletal system (19, 55, 65), alters metabolism (40), and enhances brain function (17), and thus exercise provides an excellent means of exploring the neuroendocrine connection between bone, fat, and energy balance. The rat model of exercise has been used extensively to study the physiological effects of physical activity using such exercise modalities as swimming (24, 32), running (20,29,41,49,52), jumping (57), tower climbing (43), rising to an erect bipedal stance (11, 64), and weight lifting (62). The effects of exercise on bone have been widely characterized in the rat. Ovariectomized rats undergo changes in bone structure that are nearly identical to those seen in human osteoporosis (28,42), and these animals have proven useful for the study of exercise interventions in osteoporosis treatment (36).In examini...

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“…Hunger forces individuals to move and hunt. Alternate day fasting combined with exercise is more beneficial for muscle mass than exercise alone (Sakamoto and Grunewald, 1987). In non-obese subjects, CR combined with exercise has synergistic effects on insulin sensitivity and the lowering of circulating C-reactive protein (Solomon et al, 2010).…”

Section: Healthy Aging To Combat Diseasesmentioning

confidence: 99%

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

Cabo

Carmona-Gutiérrez

Bernier

et al. 2014

Cell

301

276

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The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.

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Beneficial Effects of Exercise on Growth of Rats During Intermittent Fasting

Cited by 22 publications

References 25 publications

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Short-term voluntary exercise in the rat causes bone modeling without initiating a physiological stress response

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

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