Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice

Yang, Czau‐Siung; Xu, Zhenxia; Deng, Qianchun; Huang, Qingde; Wang, Xu; Huang, Fenghong

doi:10.1016/j.foodres.2020.108994

Cited by 86 publications

(66 citation statements)

References 63 publications

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“…The decreased F/B ratio caused by FSP fermentation suggested that FSP might have a beneficial effect on host weight loss. It has been demonstrated that FSP decreased the F/B ratio and inhibited obesity in high-fat-diet mice [ 20 ]. Additionally, at genus level, fermentation with FSP exhibited a higher Phascolarctobacterium but lower Bifidobacterium and Faecalibacterium in comparison with INU groups ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…Increasing evidence has suggested that Prevotella are beneficial gut microbiota that can improve glucose metabolism [ 38 ]. The bloom of Prevotella by FSP suggested it could be used in maintain blood glucose stability in body as reported in mice [ 20 ] and rats [ 39 ]. Dialister was also stimulated by FSP and inulin both, it has been reported to use pectin as a substrate [ 40 ] and produce SCFAs [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…Our previous work demonstrated that FSP alleviated metabolic syndrome by modulating the gut microbiota and increasing the content of SCFAs in high-fat-diet mice [ 20 ]. However, there has been little study regarding the digestion and fermentation characteristics of FSP.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Digestion and Fermentation by Human Fecal Microbiota of Polysaccharides from Flaxseed

et al. 2020

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The digestion of flaxseed polysaccharides (FSP) in simulated saliva, gastric and small intestine conditions was assessed, as well as in vitro fermentation of FSP by human gut microbiota. FSP was not degraded in the simulated digestive systems (there was no change in molecular weight or content of reducing sugars), indicating that ingested FSP would reach the large intestine intact. Changes in carbohydrate content, reducing sugars and culture pH suggested that FSP could be broken down and used by gut microbiota. FSP modulated the composition and structure of the gut microbiota by altering the Firmicutes/Bacteroidetes ratio and increasing the relative abundances of Prevotella, Phascolarctobacterium, Clostridium and Megamonas, which can degrade polysaccharides. Meanwhile, FSP fermentation increased the concentration of short-chain fatty acids, especially propionic and butyric acids. Our results indicate that FSP might be developed as a functional food that benefits gut health.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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In Vitro Digestion and Fermentation by Human Fecal Microbiota of Polysaccharides from Flaxseed

et al. 2020

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“…The regulation of lipogenic gene expression is mainly mediated by transcription factors, among which, Srebp1 is a master regulator to most hepatic lipid synthesis genes, including Fas, Acc, and Scd1 (Guo et al, 2018;Zhou et al, 2020). Fas, provides a non-esterified fatty-acid substrate for triacylglycerol, resulting in enhanced fatty acid synthesis and TG accumulation (Yang et al, 2020). Acc converts acetyl-CoA to malonyl CoA, which participates in the synthesis of fatty acids (Li et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice

et al. 2020

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“…All data presented herein were obtained from refs. [44,54,55,70,72,74,75,78,88,95,96,98,[102][103][104][105][106][107][108][109][110][111]116,[119][120][121][124][125][126][127][128][129][130]132,[134][135][136][137][140][141][142][143][144][147][148][149][150][151][152][153][154]…”

Section: Resultsmentioning

confidence: 99%

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Leonardi

Gosmann

Zimmer

2020

Molecular Nutrition Food Res

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Standardized animal models represent one of the most valuable tools available to understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new therapeutic strategies. However, there is considerable variability in the studies conducted with this essential purpose. This review presents an updated discussion of the most recent studies using diverse experimental conditions to induce MetS in rodents with unbalanced diets, discusses the key findings in metabolic outcomes, and critically evaluates what we have been learned from them and how to advance in the field. The study includes scientific reports sourced from the Web of Science and PubMed databases, published between January 2013 and June 2020, which used hypercaloric diets to induce metabolic disorders, and address the impact of the diet on metabolic parameters. The collected data are used as support to discuss variables such as sex, species, and age of the animals, the most favorable type of diet, and the ideal diet length to generate metabolic changes. The experimental characteristics propose herein improve the performance of a preclinical model that resembles the human MetS and will guide researchers to investigate new therapeutic alternatives with confidence and higher translational validity.

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Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice

Cited by 86 publications

References 63 publications

In Vitro Digestion and Fermentation by Human Fecal Microbiota of Polysaccharides from Flaxseed

In Vitro Digestion and Fermentation by Human Fecal Microbiota of Polysaccharides from Flaxseed

Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice

Modeling Diet‐Induced Metabolic Syndrome in Rodents

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