Beneficial effects of Fu-Zheng-Qu-Zhuo oral liquid combined with standard integrated therapy in patients with chronic kidney disease (stage 3–4)

Шен, Ли; Rao, Xiang-rong; Dai, Xi-wen; Pei, Kemei; Wang, Lee; Huo, Bao-Min; Wang, Xiujuan; Kong, Lingxin; Zhang, Nannan; Lian, Fengmei

doi:10.1097/md.0000000000007448

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…The Yishen Huanshuai recipe, consisting of Astragalus membranaceus, Codonopsis radix, Angelica sinensis radix, chuanxiong rhizome, honeysuckle, Hedyotis diffusa, Poria cocos, Alisma orientale, plantain, and rhubarb, has played a significant role in supplementing Qi and activating blood circulation, removing dampness, and purging turbidity. [5,37] As the disease progresses, patients often experience edema, difficulty urinating, fatigue, nausea, palpitations, wheezing, and an inability to lie down. Using the Yishen Huanshuai recipe as a base, additional herbs can also be prescribed to assist diuresis and alleviate edema to maintain the function of the Qi transformation of the kidneys.…”

Section: Treatment Of Ckd-cvd Using CMmentioning

confidence: 99%

“…[25] PATHOGENESIS OF CKD-CVD ACCORDING TO CM CM slows CKD progression and improves the patient's quality of life. [5] Several meta-analyses of the treatment of patients with CKD and CM have shown that CM has good clinical efficacy. [26,27] Due to the complex pathophysiological process of CKD-CVD, the above-mentioned treatments to control traditional risk factors have not achieved the expected efficacy in reducing CVD mortality in patients with CKD.…”

Section: Calcium and Phosphorus Metabolism Managementmentioning

confidence: 99%

“…[3] In cases of CKD-CVD, Chinese medicine (CM) plays an important role in delaying the progressive decline of renal function. [5] Therefore, understanding the clinical characteristics of CKD-CVD and discussing its basic pathogenesis from the perspective of CM is of great importance for its treatment. This article summarizes the clinical characteristics and main treatments of CKD-CVD, focusing on its pathogenesis and treatment from the perspective of CM, in order to provide some reference for the combined treatment of Chinese and Western medicine for CKD-CVD.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics and Chinese Medicine Therapy of Chronic Kidney Disease Combined with Cardiovascular Disease

Zhu¹,

Du²,

Xuan³

et al. 2023

Integr Med Nephrol Androl

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Chronic kidney disease (CKD) is a serious public health concern worldwide. Cardiovascular disease (CVD) is the leading cause of death in CKD patients. CKD combined with CVD (CKD-CVD) is a common disease with a poor prognosis. Modern medicine for the treatment of CKD-CVD currently focuses on controlling the traditional risk factors of CVD. However, its efficacy is lower than expected, and revascularization shows no notable benefit to patients. The reason for this unsatisfactory clinical outcome is that CKD-CVD has a specific pathophysiological mechanism and atypical clinical presentation. Due to the inadequacy of the therapeutic effects of modern medicine, Chinese medicine (CM) is recommended to delay disease progression. CM is widely used to treat CKD. Furthermore, some theoretical and clinical explorations on the CM treatments of CKD-CVD have been undertaken in recent years. However, clinical trials on the long-term effects of CM on cardiovascular outcomes in patients with CKD is lacking, especially studies on combined cardiac and renal endpoints. This article summarises the clinical characteristics and main treatments of CKD-CVD. Besides, based on CM theory, it is proposed that a deficiency of the spleen and kidney Qi, water dampness, dampness turbidity, and blood stasis contribute to the pathogenesis of CKD-CVD, treatment should focus on tonifying the spleen and kidney Qi, supplemented by smoothing the triple energizer, detoxification, and activation of blood circulation. In order to provide some reference for the combined treatment of Chinese and Western medicine for CKD-CVD.

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Section: Treatment Of Ckd-cvd Using CMmentioning

confidence: 99%

Section: Calcium and Phosphorus Metabolism Managementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics and Chinese Medicine Therapy of Chronic Kidney Disease Combined with Cardiovascular Disease

Zhu¹,

Du²,

Xuan³

et al. 2023

Integr Med Nephrol Androl

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Understanding and Therapeutic Strategies of Chinese Medicine on Gut-Derived Uremic Toxins in Chronic Kidney Disease

Guo

Rao

2018

Chin. J. Integr. Med.

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Chronic kidney disease (CKD) is a major disease that threatens human health. With the progression of CKD, the risk of cardiovascular death increases, which is associated with the elevated levels of uremic toxins (UTs). Representative toxins such as indoxyl sulfate and p-cresyl sulfate are involed in CKD progression and cardiovascular events inseparable from the key role of endothelial dysfunction. The therapeutic strategies of UTs are aimed at signaling pathways that target the levels and damage of toxins in modern medicine. There is a certain relevance between toxins and "turbid toxin" in the theory of Chinese medicine (CM). CM treatments have been demonstrated to reduce the damage of gut-derived toxins to the heart, kidney and blood vessels. Modern medicine still lacks evidence-based therapies, so it is necessary to explore the treatments of CM.

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New Goals and Strategies of Chinese Medicine in Prevention and Treatment of Chronic Kidney Disease

Guo

Shen

Rao

2019

Chin. J. Integr. Med.

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Beneficial effects of Fu-Zheng-Qu-Zhuo oral liquid combined with standard integrated therapy in patients with chronic kidney disease (stage 3–4)

Abstract: Supplemental Digital Content is available in the text

Cited by 7 publications

References 13 publications

Clinical Characteristics and Chinese Medicine Therapy of Chronic Kidney Disease Combined with Cardiovascular Disease

Clinical Characteristics and Chinese Medicine Therapy of Chronic Kidney Disease Combined with Cardiovascular Disease

Understanding and Therapeutic Strategies of Chinese Medicine on Gut-Derived Uremic Toxins in Chronic Kidney Disease

New Goals and Strategies of Chinese Medicine in Prevention and Treatment of Chronic Kidney Disease

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