Beneficial effects of gluten free diet on IgA tissue transglutaminase levels and various growth parameters in celiac disease patients

Hota, Dayanand; Bhalla, Kapil; Nanda, Sanjiv; Gupta, Ashish; Mehra, Shuchi

doi:10.4103/jfmpc.jfmpc_56_19

Cited by 5 publications

(2 citation statements)

References 26 publications

(25 reference statements)

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“…However, an alarm signal must be raised to raise awareness of the possible implications of some drugs commonly used in clinical practice, when their method of preparation is not fully understood by the clinician. The benefits of GFD regarding the reduction of celiac disease morbidity were most of the time indisputable, both for symptomatic and asymptomatic patients (219)(220)(221). The literature also notes superior results of GFD among children, compared to adults (222).…”

Section: General Therapeutic Linesmentioning

confidence: 99%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially in pediatrics, celiac disease (also called gluten enteropathy), is gaining more and more ground in terms of diagnosis, but also interest in research. The data from the literature of the last decades attest the chameleonic way of its presentation, there may be both classic onset symptoms and atypical symptoms. Given the impact played by celiac disease, especially in the optimal growth and development of children, the current narrative review aims to highlight the atypical presentation methods, intended to guide the clinician towards the inclusion of the pathology in the differential diagnosis scheme. To these we add the summary presentation of the general data and therapeutic lines regarding the underlying condition and the existing comorbidities. In order to place the related information up to date, we performed a literature review of the recent articles published in international databases. We bring forward the current theories and approaches regarding both classic celiac disease and its atypical manifestations. Among these we note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, but also disorders of biological constants and association with multiple autoimmunities. Knowing and correlating them with celiac disease is the key to optimal management of patients, thus reducing the subsequent burden of the disease.

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Section: General Therapeutic Linesmentioning

confidence: 99%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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“…If the cut-off value shifts from 1× ULN to 10× ULN, the sensitivity for CeD diagnosis decreases from 72.5%–98.6% ( 18 , 19 ) to 51.9%–70.0% ( 19 , 20 ). The concentration of tTG-IgA decreases in patients on a GFD ( 21 ), affecting the ability of this biomarker to predict mucosal recovery. Thus, a normalization of tTG-IgA levels cannot be interpreted as reflecting a healing of the mucosa or improvement of VA ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Serological Investigation of Persistent Villous Atrophy in Celiac Disease

Gong,

Saborit,

Long

et al. 2023

Clin Transl Gastroenterol

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Introduction: Persistent villous atrophy (VA) is not uncommon in celiac disease (CeD) while patients take a gluten-free diet (GFD). Methods: We conducted a retrospective study with 122 serum samples collected from controls and CeD patients either at the initial diagnosis or follow-up during endoscopy. These samples were assigned to three groups: non-celiac control, non-VA CeD (Marsh score 0-2), and VA CeD (Marsh score 3a-3c). We established an in-house multiplex assay to identify potential serological biomarkers for villous atrophy. We assessed autoantibodies reported to affect the small intestine, including IgA and IgG antibodies against tissue transglutaminase (tTG), interferons, villin, actin, autoimmune enteropathy-related 75 kDa antigen (AIE-75), and tryptophan hydroxylase (TPH)-1, as well as 27 cytokines. The apolipoproteins quantified included apo A1, apo B-100, and apo A4, which were produced predominantly by the intestinal epithelium or expressed specifically in villi. Results: Autoantibody levels were high only for tTG antibodies, which performed well in initial CeD diagnosis, but suboptimally for VA prediction during follow-up, as 14.6% of the follow-up patients with VA had low tTG-IgA. Increasing dilution improved tTG-IgA quantification, particularly when the antibody levels were extremely high, but did not significantly improve VA detection. Among those with low tTG-IgA and persistent VA, high proinflammatory cytokines were observed in two patients. Median LDL-C levels were significantly lower in the VA CeD group (P = 0.03). Apolipoprotein levels were similar in patients with and without VA, but diverged between those on a gluten-free diet (GFD) or not. Conclusions: tTG-IgA as a biomarker is suboptimal for villous atrophy prediction while on a GFD. Persistent villous atrophy is associated with low LDL-C levels, and partially related to persistent high proinflammatory cytokines.

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Incidence of celiac disease autoimmunity and associations with maternal tuberculosis and pediatric Helicobacter pylori infections in 4-year-old Ethiopian children followed up in an HLA genotyped birth cohort

Gudeta

Aronsson²,

Binagdie³

et al. 2022

Front. Pediatr.

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BackgroundThe prevalence of celiac disease in the general population is mainly unknown in most of sub-Saharan African countries. The aim of this study was to determine the incidence of celiac disease autoimmunity (CDA) and its associations with latent Mycobacterium tuberculosis (LMTB) and Helicobacter pylori (HP) infections in Ethiopian children aged 4 years in an HLA genotyped cohort study.MethodsOf 1,389 recruited children between 2018 and 2022, 1,046 (75.3%) had been screened at least twice for celiac disease between the ages of 2 and 4 years using a tissue transglutaminase autoantibody (tTGA) ELISA kit. Tissue TGA-positive children were retested using radio-binding assays. CDA was defined as persistent-confirmed tTGA positivity in two consecutive samples. Associations of CDA with LMTB and HP were tested in a subpopulation of 752 children born to mothers who were previously tested for LMTB with IFN-γ and anti-HP antibodies in samples collected at a mean age of 49.3 ± 5.3 months.ResultsScreening detected 38 out of 1,046 (3.6%) IgA-tTGA-positive children. Ten (1.0%) were confirmed to be positive, with six (0.6%) children diagnosed with CDA. The incidence of CDA at 4 years of age was 1.2 per 1,000 person-years. LMTB was found in 4 of 6 (66.7%) mothers with CDA children compared with 340 of 734 (46.3%) mothers of children without CDA (p = 0.424), while HP was found in 3 of 6 (50.0%) CDA children compared with 315 of 746 (42.2%) children without CDA (p = 0.702).ConclusionThe incidence of CDA in Ethiopian children is lower than the pooled global incidence. Neither LMTB nor HP infections are associated with CD in Ethiopian children.

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Beneficial effects of gluten free diet on IgA tissue transglutaminase levels and various growth parameters in celiac disease patients

Cited by 5 publications

References 26 publications

Celiac disease - a pluripathological model in pediatric practice

Celiac disease - a pluripathological model in pediatric practice

Serological Investigation of Persistent Villous Atrophy in Celiac Disease

Incidence of celiac disease autoimmunity and associations with maternal tuberculosis and pediatric Helicobacter pylori infections in 4-year-old Ethiopian children followed up in an HLA genotyped birth cohort

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