Beneficial effects of gluten free diet in potential coeliac disease in adult population

Imperatore, Nicola; Tortora, Raffaella; Palma, Giovanni Domenico De; Capone, P.; Gerbino, N.; Donetto, Sara; Testa, Anna; Caporaso, Nicola; Rispo, Antonio

doi:10.1016/j.dld.2017.03.009

Cited by 16 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with current guidelines, CD diagnosis was made in the presence of Marsh ≥ 2 histology associated with both anti‐tissue transglutaminase (a‐tTG) IgA > 7 U/mL and positive anti‐endomysial (EMA) antibodies . All subjects with positive serology but negative histology (Marsh 0 or 1) underwent further investigations for genetic susceptibility and were diagnosed as “potential” CD in the presence of HLA DQ2/DQ8 . Histopathological findings were graded according to Marsh et al…”

Section: Methodsmentioning

confidence: 99%

The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease

et al. 2017

Self Cite

View full text Add to dashboard Cite

We investigated the role of HFE C282Y, H63D, and TMPRSS6 A736V variants in the pathogenesis of iron deficiency anemia (IDA) in celiac disease (CD) patients, at diagnosis and after 1 year of gluten-free diet (GFD). Demographic and clinical features were prospectively recorded for all CD patients between 2013 and 2017. C282Y, H63D, and A736V variants were evaluated for CD patients and controls. Finally, 505 consecutive CD patients and 539 age-matched control subjects were enrolled. At diagnosis, 229 CD subjects had IDA (45.3%), with a subgroup of anemic patients (45.4%) presented persistent IDA at follow-up. C282Y allele frequency was significantly increased in CD compared with controls (1.1% vs 0.2%, P = .001), whereas H63D and A736V allele frequencies were similar among patients and controls (P = .92 and .84, respectively). At diagnosis, C282Y variant in anemic CD patients was significantly increased compared to nonanemic group (2% and 0.5%, P = .04). At follow-up, A736V was significantly increased in IDA persistent than in IDA not persistent (57.7% vs 35.2%, P < .0001). CD patients with H63D mutation showed higher Hb, MCV, serum iron, and ferritin levels than subjects without HFE mutations. Decreased hepcidin values were observed in anemic compared to nonanemic subjects at follow-up (1.22 ± 1.14 vs 2.08 ± 2.15, P < .001). This study suggests a protective role of HFE in IDA CD patients and confirms the role of TMPRSS6 in predicting oral iron response modulating hepcidin action on iron absorption. Iron supplementation therapeutic management in CD could depend on TMPRSS6 genotype that could predict persistent IDA despite iron supplementation and GFD.

show abstract

Section: Methodsmentioning

confidence: 99%

The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Imperatore et al. showed that over a six‐year period, 69% of asymptomatic potential CD developed CD‐related symptoms 38 . In our study, all anti‐EMA positive donors but one, were diagnosed with CD (from which one patient refused biopsy but is most probably CD).…”

Section: Discussionmentioning

confidence: 44%

“…37 Imperatore et al showed that over a six-year period, 69% of asymptomatic potential CD developed CDrelated symptoms. 38 In our study, all anti-EMA positive donors but one, were diagnosed with CD (from which one patient refused biopsy but is most probably CD). Our findings reiterate the importance of follow-up serology and of confirmatory anti-EMA testing in establishing the true prevalence of CD autoimmunity and of CD when studying populations.…”

Section: Discussionmentioning

confidence: 54%

Rising prevalence of celiac disease is not universal and repeated testing is needed for population screening

et al. 2019

View full text Add to dashboard Cite

Background: Recent studies suggest that the prevalence of celiac disease is rising. We previously established the prevalence of celiac disease in healthy blood donors in 2002. Objective: The purpose of this study was to examine whether the prevalence of celiac disease and celiac disease autoimmunity has changed over time by performing a similar prospective study. Methods: Healthy blood donors (n ¼ 1908) were tested for tissue transglutaminase antibodies and for anti-endomysial antibodies when positive. Further evaluation followed accepted criteria for diagnosis. Results: Overall, 32 donors had abnormal tissue transglutaminase antibodies (1.68%). Eight donors had tissue transglutaminase antibodies >3 Â upper limit of normal (0.42%), two of them with tissue transglutaminase antibodies >10 Â upper limit of normal, while 24 donors had tissue transglutaminase antibodies <3 Â upper limit of normal (1.26%). Most of the donors with positive tissue transglutaminase antibodies <3 Â upper limit of normal had negative tissue transglutaminase antibodies levels on repeated testing (18/19). Celiac disease was diagnosed in four donors with positive tissue transglutaminase antibodies, establishing a prevalence of 1.68% (95% confidence interval 1.15-2.3) for celiac disease autoimmunity and 0.21% for celiac disease (95% confidence interval 0.07-0.5%). Conclusion: The prevalence of celiac disease in blood donors in Israel did not rise in the last 15 years, suggesting that the increased prevalence of diagnosed celiac disease is mainly due to increased awareness. As most of the donors with elevated tissue transglutaminase antibodies <3 Â upper limit of normal were endomysial antibody negative and had a negative tissue transglutaminase antibodies result upon re-testing, repeated tissue transglutaminase antibodies testing is required when screening asymptomatic populations for celiac disease.

show abstract

“…Some patients were affected by non-classical CD – they either experienced mild gastrointestinal symptoms without clear signs of malabsorption, or presented with other extra-intestinal conditions (chronic fatigue, chronic migraine, peripheral neuropathy, chronic hypertransaminasemia, reduced bone mass and bone fractures, dermatitis herpetiformis, etc.) [28, 29]. …”

Section: Methodsmentioning

confidence: 99%

Beyond Irritable Bowel Syndrome: The Efficacy of the Low Fodmap Diet for Improving Symptoms in Inflammatory Bowel Diseases and Celiac Disease

Testa

Imperatore

Rispo

et al. 2018

Dig Dis

Self Cite

View full text Add to dashboard Cite

Background and Aim: To evaluate the usefulness of a low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) diet on patients with irritable bowel syndrome (IBS), non-active inflammatory bowel diseases (IBD), and celiac disease (CD) on a gluten-free diet (GFD). Methods: Dietetic interventional prospective study. IBS, IBD, and CD subjects were evaluated to check if they fulfilled the Rome III criteria. Each subject was educated to follow a low FODMAP diet after being evaluated by filling out questionnaires that assessed the quality of life (QoL) and symptoms experienced (IBS-SSS and SF-36), and was reevaluated after 1 and 3 months. Results: One hundred twenty-seven subjects were enrolled: 56 with IBS, 30 with IBD, and 41 with CD. IBS-SSS showed that abdominal symptoms improved after 1 and 3 months of diet in all subjects, with significant difference among the 3 groups at T0 (average scores IBS: 293 ± 137, IBD: 206 ± 86, CD: 222 ± 65, p < 0.001), but no difference at T3 (IBS: 88 ± 54, IBD: 73 ± 45, CD: 77 ± 49, p = ns). By analyzing the SF-36 questionnaire, we did not observe any difference between the 3 groups, in terms of response to diet (p = ns), we observed a clinical improvement from T0 to T3 for most of the questionnaire’s domains. Conclusions: A low FODMAP diet could be a valid option to counter abdominal symptoms in patients with IBS, non-active IBD, or CD on a GFD, and thus, improve their QoL and social relations.

show abstract

Beneficial effects of gluten free diet in potential coeliac disease in adult population

Abstract: Although PCD with normal mucosa seems to be a milder disease, the continuation of GCD places patients at a high risk of developing villous atrophy and IMD compared to commencement of GFD. Adult PCD patients should start GFD even if not symptomatic.

Cited by 16 publications

References 26 publications

The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease

The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease

Rising prevalence of celiac disease is not universal and repeated testing is needed for population screening

Beyond Irritable Bowel Syndrome: The Efficacy of the Low Fodmap Diet for Improving Symptoms in Inflammatory Bowel Diseases and Celiac Disease

Contact Info

Product

Resources

About