Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Abstract

Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

Efficiency of Multifunctional Antibacterial Hydrogels for Chronic Wound Healing in Diabetes: A Comprehensive Review

“…In recent years, EGCG has been the subject of extensive research, 66 , 67 and its anticancer, anti-inflammatory, antioxidant, and anti-aging properties have led to its wide application in a number of fields. 66 EGCG and its wound dressings play various roles in different wound healing stages, such as increasing hemadsorption, inhibiting neutrophil infiltration and monocyte migration and adhesion, promoting re-epithelialization, stimulating angiogenesis, altering collagen synthesis, and reducing ECM formation ( Figure 4A ).…”

“…In recent years, EGCG has been the subject of extensive research, 66 , 67 and its anticancer, anti-inflammatory, antioxidant, and anti-aging properties have led to its wide application in a number of fields. 66 EGCG and its wound dressings play various roles in different wound healing stages, such as increasing hemadsorption, inhibiting neutrophil infiltration and monocyte migration and adhesion, promoting re-epithelialization, stimulating angiogenesis, altering collagen synthesis, and reducing ECM formation ( Figure 4A ). 66 A team from Xi’an Jiao-tong University produced a smart hydrogel dressing, 68 which can be conveniently obtained through copolymerization of the complex formed by EGCG and 3-acrylamido phenyl boronic acid (APBA) (resulting in the formation of boronate ester bond) with acrylamide.…”

“… 66 EGCG and its wound dressings play various roles in different wound healing stages, such as increasing hemadsorption, inhibiting neutrophil infiltration and monocyte migration and adhesion, promoting re-epithelialization, stimulating angiogenesis, altering collagen synthesis, and reducing ECM formation ( Figure 4A ). 66 A team from Xi’an Jiao-tong University produced a smart hydrogel dressing, 68 which can be conveniently obtained through copolymerization of the complex formed by EGCG and 3-acrylamido phenyl boronic acid (APBA) (resulting in the formation of boronate ester bond) with acrylamide. Scine E-A complexes are dynamic, the resulting hydrogels have good mechanical strength, moderate tissue adhesiveness and excellent self-regeneration capacity, which largely facilitates regeneration and self-healing.…”

Electro spun polymeric membranes for wound healing

“…(−)-Epigallocatechin gallate (EGCG) is regarded as the most abundant compound in tea leaves with excellent bioactivities, such as antioxidant/free radical scavenging, antiinflammatory and antimicrobial properties. However, the clinical application of EGCG is restricted by its low bioavailability, since EGCG is unstable under the alkalescent condition of the intestinal track and circulatory system [89]. 7.…”

Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway

“…In recent years, the interest in green tea has grown because of its lack of toxicity and good efficacy in a wide range of organs, such as retinal, brain and skin ( 7 – 9 ). Green tea contains >3,000 compounds, of which nearly one-third are polyphenols that include catechins such as (−)-epicatechin (EC), (−)-EC gallate (ECG), (−)-epigallocatechin (EGC) and (−)-EGC gallate (EGCG) ( 8 ).…”