Beneficial Effects of Honey Flavonoids in Nonalcoholic Fatty Liver Disease: An Update

Taleuzzaman, Mohamad; Verma, Rishabh; Kala, Chandra; Sharma, Parul; Gupta, Dipak Kumar

doi:10.1007/978-981-15-7305-7_17

Cited by 1 publication

(2 citation statements)

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“…Previous study has proven that intake of fructose in moderate amount can prolong gastric emptying, which in turn delays intestinal absorption and lowers food intake to result in reducing weight gain. 23 Samat et al 24 has also reported similar findings in obesity induced rats but using Gelam and Acacia honey instead. The recent finding may suggest the potential of TH to be recommended as a supplement for weight reduction.…”

Section: Discussionmentioning

confidence: 72%

“…The significant reduction in the bodyweight of the rats with the change of diet and supplementation with TH, is supported by several other studies that focused on hypoglycaemic properties of honey. [20][21][22][23] Honey in general and TH in particular is essentially composed of fructose, glucose and other sugars. Previous study has proven that intake of fructose in moderate amount can prolong gastric emptying, which in turn delays intestinal absorption and lowers food intake to result in reducing weight gain.…”

Section: Discussionmentioning

confidence: 99%

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Tualang Honey Supplementation Alleviates Obesity and Dyslipidaemia in High Cholesterol Diet Induced Non-Alcoholic Steatohepatitis Animal Model

Alias

Rahim

Muhamad

et al. 2022

imjm

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INTRODUCTION: Dyslipidaemia and obesity are two main features of non-alcoholic steatohepatitis (NASH). This study aimed to investigate the effects of Tualang honey (TH) supplementation on bodyweight, liver weight, and lipid profiles in high cholesterol diet (HCD) induced NASH animal model. MATERIALS AND METHODS: Sixteen Sprague-Dawley rats were given 12% HCD for 16 weeks to induce NASH. These animals were divided into 4 groups; Group 1 (continued HCD), Group 2 (changed to normal diet), Group 3 (normal diet and TH 1.2g/kg) and Group 4 (normal diet and TH 3.0g/kg) for the following 4 weeks. Bodyweight was measured daily. At the end of the study, blood was collected via retro-orbital bleeding and the rats were sacrificed to harvest their liver. RESULTS: The group 4 rats had significantly lower mean final bodyweight than rats in group 1, 2 and 3 (478.0±24.4 vs. 641.5±25.1, 593.8 ±29.3, 552.0±72.9 g, p<0.05). Animals in group 4 were also found to have a significantly lower mean liver weight compared to groups 1 and 2 (12.9±0.9 vs 20.1±2.2, 15.7±1.2 g, p<0.05). In comparison to controls, the mean concentration of total cholesterol was significantly lower in all the other groups and the lowest mean concentration of triglycerides was recorded in group 4 with significant difference when compared to the controls (0.9±0.4 vs 3.6±0.4 mmol/L, p<0.05). CONCLUSION: The change from HCD to a normal diet coupled with TH supplementation has been shown to reduce bodyweight, liver weight, total cholesterol and triglyceride levels in the 12% HCD NASH induced animal models.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%