2009
DOI: 10.1016/j.jtbi.2008.12.005
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Beneficial effects of intercellular interactions between pancreatic islet cells in blood glucose regulation

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Cited by 22 publications
(25 citation statements)
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“…6,12,13 It has been suggested that the tonic inhibitory input from the δ-cells in response to nutrient stimuli may prevent wasteful co-secretion of insulin and glucagon. 14 In conclusion, our studies using Sst -/-islets suggest that paracrine interactions between δ-and α-cells provide an intra-islet, SST-mediated control mechanism which facilitates and fine-tunes the release of glucagon in response to sympathetic activation.…”
Section: Discussionmentioning
confidence: 67%
“…6,12,13 It has been suggested that the tonic inhibitory input from the δ-cells in response to nutrient stimuli may prevent wasteful co-secretion of insulin and glucagon. 14 In conclusion, our studies using Sst -/-islets suggest that paracrine interactions between δ-and α-cells provide an intra-islet, SST-mediated control mechanism which facilitates and fine-tunes the release of glucagon in response to sympathetic activation.…”
Section: Discussionmentioning
confidence: 67%
“…To unravel the mechanism of interaction between insulin, glucagon and somatostatin, Jo et al (Jo et al, 2009) proposed a compartmental mathematical model of α-, β-, and δ-cells. In the model, each compartment can take one of two states: active and silent.…”
Section: Islets Have An Optimal Functional Size and Architecturementioning
confidence: 99%
“…[112][113][114][115][116] Their complex behaviors, however, may not obviously be addressed by probing α-, β-and δ-cells separately. Even if they are not physically connected with each other, they communicate with each other via paracrine interactions which are mediated by hormones [117][118][119][120] or neurotransmitters.…”
Section: Paracrine Interactions Among Islet Cellsmentioning
confidence: 99%
“…On the other hand, the role of δ-cells is not fully known although there are reports that somatostatin secreted from δ-cells inhibits both α and β-cells. [127][128][129][130] In conclusion, despite both theoretical and experimental efforts as to the questions over the past 30 y, [112][113][114][115][116]127,128,131 there still lacks concrete understanding of the roles of the paracrine interactions among islet cells in glucose homeostasis. A variety of complicated interactions in an islet makes it difficult to recognize their roles, and existing experiments have focused mostly on static responses of the endocrine cells.…”
mentioning
confidence: 99%
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