Beneficial effects of intermittent fasting: a narrative review

Song, Dae-Kyu; Kim, Yong Woon

doi:10.12701/jyms.2022.00010

Cited by 26 publications

(7 citation statements)

References 101 publications

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“…The clinical trial by Stekovic et.al in which IF was applied to a medium‐sized human cohort for a long period of time has shown that IF is more tolerable than sustained calorie restriction to improve cardiovascular system and body composition 10 . More importantly, IF has been demonstrated to be safe to practice in healthy non‐obese adults for more than 6 months 11 . Metabolic transformation of fed‐fast cycle induced by IF significantly enhances the anti‐stress and protective capacity of cells, which promotes cell repair, induces autophagy, and optimizes stress responses 12–14 …”

Section: Introductionmentioning

confidence: 99%

“…10 More importantly, IF has been demonstrated to be safe to practice in healthy non-obese adults for more than 6 months. 11 Metabolic transformation of fed-fast cycle induced by IF significantly enhances the anti-stress and protective capacity of cells, which promotes cell repair, induces autophagy, and optimizes stress responses. [12][13][14] The impact of long-term IF before pregnancy on offspring metabolism remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling

et al. 2023

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The metabolic benefits of intermittent fasting (IF) have been well recognized. However, limited studies have examined the relationship between long‐term maternal IF before pregnancy and offspring health. In this study, a C57BL/6J mouse model of long‐term IF before pregnancy was established: 4‐week‐old female mice were subjected to alternate‐day fasting for 12 weeks and resumed normal diet after mating. Female mice in the control group were fed ad libitum. Offspring mice were weaned at 6 weeks of age and fed a normal chow diet or a 60% high‐fat diet. The effects of long‐term pre‐pregnancy IF on offspring metabolism and its underlying mechanism were examined. We found that neonatal IF offspring weighted significantly less relevant to control mice. This difference gradually disappeared as a result of catch‐up growth. In the IF offspring, adipose tissue mass was significantly increased. This alteration was associated with a considerable deterioration in glucose tolerance. No significant difference in food intake was observed. Further, lipid deposition as well as triglyceride contents in the liver were greatly increased. Maternal IF significantly decreased levels of DNA methyltransferase in the liver of offspring. DNA methylation modifications of molecules associated with the mTORC1 signaling pathway were significantly altered, leading to the significant inhibition of mTORC1 signaling. Overexpression of S6K1 activated hepatic mTORC1 signaling and reversed the metabolic dysfunction in IF offspring. In conclusion, long‐term pre‐pregnancy IF increases hepatic steatosis and adiposity, as well as impairs glucose metabolism in adult offspring. This occurs through DNA methylation‐dependent suppression of hepatic mTORC1 signaling activity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling

et al. 2023

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“…Durante los períodos de ayuno, se evita la ingesta de alimentos durante un tiempo específico, que puede variar desde unas pocas horas hasta un día completo o más, seguido de períodos en los que se permite la alimentación dentro de una ventana de tiempo determinada (Song & Kim, 2023).…”

Section: Resultsunclassified

Ayuno Intermitente y la Prevención De Enfermedades Metabólicas. Revisión de la Literatura

Pintado Ruiz,

Mancheno Romero,

García Ramón

et al. 2024

Ciencia Latina

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Entre las ventajas que tiene el ayuno intermitente esta a disminución de ingestas de energía, carbohidratos y grasas contribuyen al tratamiento y prevención de enfermedades crónicas que incluyen enfermedades cardiovasculares, cáncer, diabetes y trastornos neurológicos. También existe una mejoría en la calidad del sueño, la memoria, la capacidad de concentración y el estado de alerta durante el día. Entonces por que después de tantos beneficios descritos, ¿por qué no es usado en la práctica clínica diaria?, esta es la pregunta inicial para desarrollar este articulo por lo que el objetivo es describir el ayuno intermitente y su relación con la prevención de enfermedades metabólicas. Se necesita más investigación para establecer pautas claras y personalizadas para la implementación clínica del ayuno intermitente, teniendo en cuenta los posibles efectos secundarios y la tolerabilidad a largo plazo. Sin embargo, dada su capacidad para complementar las estrategias convencionales de manejo de la obesidad y las enfermedades metabólicas, el ayuno intermitente representa una opción terapéutica prometedora que merece una atención continua en la investigación y la práctica clínica.

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“…CR and intermittent fasting stimulates autophagy mainly by decreasing mTOR signaling by reducing insulin and IGF-1 levels and increasing the AMP/ATP ratio that leads to the activation of AMPK as well as several products involved in the stimulation of this process like ATG6, ATG7, ATG8, LC3-II, Beclin1, p62, Sirt1, LAMP2, ULK1 and ATG101 196 , 214 . The favorable effects on autophagy of both CR and intermittent fasting seems to be involved in the increase of fat mobilization, oxidation, metabolic flexibility, insulin sensitivity and redox imbalance together with a reduction in systemic inflammation, cardiovascular risks and body weight 215 . Hence, either CR or intermittent fasting are valuable and similar strategies to preserve health and aid in the clinical management of several diseases 216 .…”

Section: Modulation Of Autophagymentioning

confidence: 99%

Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine

Ortega,

Fraile-Martinez,

de Leon-Oliva

et al. 2024

Int. J. Biol. Sci.

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Autophagy plays a critical role in maintaining cellular homeostasis and responding to various stress conditions by the degradation of intracellular components. In this narrative review, we provide a comprehensive overview of autophagy's cellular and molecular basis, biological significance, pharmacological modulation, and its relevance in lifestyle medicine. We delve into the intricate molecular mechanisms that govern autophagy, including macroautophagy, microautophagy and chaperone-mediated autophagy. Moreover, we highlight the biological significance of autophagy in aging, immunity, metabolism, apoptosis, tissue differentiation and systemic diseases, such as neurodegenerative or cardiovascular diseases and cancer. We also discuss the latest advancements in pharmacological modulation of autophagy and their potential implications in clinical settings. Finally, we explore the intimate connection between lifestyle factors and autophagy, emphasizing how nutrition, exercise, sleep patterns and environmental factors can significantly impact the autophagic process. The integration of lifestyle medicine into autophagy research opens new avenues for promoting health and longevity through personalized interventions.

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Beneficial effects of intermittent fasting: a narrative review

Cited by 26 publications

References 101 publications

Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling

Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling

Ayuno Intermitente y la Prevención De Enfermedades Metabólicas. Revisión de la Literatura

Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine

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