Beneficial effects of intragastric balloon therapy associated with hormonal changes on weight loss and serum metabolic, inflammatory and liver parameters

Świdnicka-Siergiejko, Agnieszka Katarzyna; Wróblewski, Eugeniusz; Hady, Hady Razak; Bogdanowska-Charkiewicz, Dagmara; Dâbrowski, A

doi:10.25121/pnm.2018.31.3.138

Cited by 1 publication

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“…This finding supports the value of this kind of treatment in patients with MetS; nevertheless, little proven data exists regarding the long-term follow-up after the BIBsystem therapy, and hence its long-lasting effects are uncertain (18,19). As a minimally-invasive treatment of obesity, the BIB-system has been found to offer other beneficial effects on anthropometric parameters, glucose intolerance, metabolic disorder and certain hormone concentrations, and these are addressed in other research reports (52,53).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Noninvasive Bariatric Surgery on the Levels of Certain Adipokines and Atherosclerosis Risk Factors in Patients with Metabolic Syndrome

Wojciechowska-Kulik

Blus

Kowalczyk

et al. 2019

Journal of the American College of Nutrition

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Objective: Besides glucose intolerance, dyslipidemia, and hypertension, visceral obesity is one of the most important atherogenic pathological factors in patients with metabolic syndrome (MetS). The aim of this study is to examine whether weight loss following BioEnterics Intragastric Balloon (BIB-system) therapy affects adipokine concentration and atherosclerosis risk factor profile in patients with MetS. Methods: The study group comprised 30 patients (17 female, BMI ¼ 38.5 ± 8.6 kg/m 2 ; 13 male, BMI ¼ 43.3 ± 7 kg/m 2 ) with MetS qualified to BIB-system therapy. The control group included 18 age matched healthy volunteers (10 female, BMI ¼ 23.3 ± 2.8 kg/m 2 and eight male, BMI ¼ 27.3 ± 0.9 kg/m 2 ). Biochemical analyses of blood samples and anthropometric measurements were conducted, before and after six-month BIB system therapy. Results: BIB therapy resulted in a significant drop in body weight, and body fat percentage, and in BMI, VAI, WHtR, BAI, TG, glucose, hsCRP, and leptin levels. In addition Tc/HDL, LDL/HDL, TG/ HDL, and leptin/adiponectin ratios fell significantly, and adiponectin concentration increased. All anthropometric parameters apart from Tc and hsCRP, were significantly different post-therapy compared to healthy controls. The therapy induced downregulation of hsCRP which was positively correlated with the reduction in body weight, BMI and BAI. The decrease in leptin concentration correlated positively with the fall in total cholesterol and body weight. The fall in leptin/adiponectin ratio positively correlated with the downregulation of BAI and body fat. Conclusion: BIB therapy appears to have beneficial effects on MetS. This is indicated by amelioration of the pro-inflammatory status related to obesity, demonstrated by an improved lipid profile significant downregulation of hsCRP concentration following therapy.

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Section: Discussionmentioning

confidence: 99%