Beneficial effects of Lactococcus lactis subsp. cremoris LL95 treatment in an LPS-induced depression-like model in mice

Ramalho, Juliana Bernera; Spiazzi, Cristiano Chiapinotto; Bicca, Diogo Ferreira; Rodrigues, Jéssica Ferreira; Sehn, Carla Pohl; Silva, Wladimir Padilha da; Cibin, Francielli Weber Santos

doi:10.1016/j.bbr.2022.113847

Cited by 15 publications

(10 citation statements)

References 52 publications

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“…Lactococcus lactis subsp. cremoris LL95 exerts antidepressant-like effects in lipopolysaccharide-induced depression in mice by reducing oxidative status and inflammatory responses in the hippocampus [25]. L. lactis strain WHH2078 can alleviate depressiveand anxiety-like behaviors in mice with induced chronic unpredictable mild stress by improving 5-hydroxytryptamine metabolism, restoring BDNF levels, and modulating the gut microbiome composition [26].…”

Section: Discussionmentioning

confidence: 99%

Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice

Katayama

Okahata

Onozato³

et al. 2022

Nutrients

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Buckwheat is an important pseudo-cereal crop worldwide. This study investigated whether long-term administration of buckwheat can suppress age-related cognitive decline in senescence-accelerated mouse prone 8 (SAMP8) mice. For 26 weeks, 18-week-old male SAMP8 mice were fed a standard diet containing 5% (w/w) buckwheat, Tartary buckwheat, wheat, or rice flour. In the Barnes maze and passive avoidance tests, mice fed buckwheat whole flour (BWF) showed improved cognitive performance compared to those fed a control diet, while no improvement was noticed in case of the other diets. Analysis of the gut microbiota showed that BWF and buckwheat outer flour administration increased the abundance of Lactococcus and Ruminiclostridium, respectively, at the genus level. The expression levels of brain-derived neurotrophic factor (BDNF), postsynaptic Arc and PSD95, and the mature neuronal marker NeuN in the hippocampus were increased after BWF administration, which was induced by the activation of the ERK/CREB signaling pathway and histone H3 acetylation. A similar increase in cognitive performance-related hippocampal BDNF expression in SAMP8 mice was observed after the oral administration of starch prepared from BWF. Therefore, the long-term administration of BWF suppresses cognitive decline by increasing hippocampal BDNF production in SAMP8 mice.

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Section: Discussionmentioning

confidence: 99%

Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice

Katayama

Okahata

Onozato³

et al. 2022

Nutrients

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“… Xie et al (2020) carried out 2-week electroacupuncture intervention in mice, and found that electroacupuncture could inhibit proinflammatory shift with promoting the recovery of the relative abundance of Akkermansia , Clostridium , Lactococcus, and Butyricimonas in the intestinal tract, and significantly increase the relative abundance of Lactobacillus . A number of bacteria above are capable of inhibiting inflammation, protecting the intestinal barrier and preventing depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ). All of the above bacteria have the potential to inhibit inflammation, protect the intestinal barrier, and prevent depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ).…”

Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

et al. 2023

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Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit a variety of gastrointestinal symptoms, and even take gastrointestinal symptoms as the primary reason for medical treatment. It is well documented that stress may disrupt the balance of the gut microbiome in patients suffering from post-stroke depression (PSD), and that disruption of the gut microbiome is closely related to the severity of the condition in depressed patients. Therefore, maintaining the balance of intestinal microbiota can be the focus of research on the mechanism of acupuncture in the treatment of PSD. Furthermore, stroke can be effectively treated with acupuncture at all stages and it may act as a special microecological regulator by regulating intestinal microbiota as well. In this article, we reviewed the studies on changing intestinal microbiota after acupuncture treatment and examined the existing problems and development prospects of acupuncture, microbiome, and poststroke depression, in order to provide new ideas for future acupuncture research.

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“…With the increasing recognition of the importance of healthy gut microbiota in the development of autoimmune diseases, many studies have focused on the immunomodulatory effects of some probiotic strains [ 230 , 232 , 233 ]. In one of these studies, a Ln.…”

Section: Probiotic Potential Of Labmentioning

confidence: 99%

Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions

Coelho

Malcata

Silva

2022

Foods

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Traditional cheeses produced from raw milk exhibit a complex microbiota, characterized by a sequence of different microorganisms from milk coagulation and throughout maturation. Lactic acid bacteria (LAB) play an essential role in traditional cheese making, either as starter cultures that cause the rapid acidification of milk or as secondary microbiota that play an important role during cheese ripening. The enzymes produced by such dynamic LAB communities in raw milk are crucial, since they support proteolysis and lipolysis as chief drivers of flavor and texture of cheese. Recently, several LAB species have been characterized and used as probiotics that successfully promote human health. This review highlights the latest trends encompassing LAB acting in traditional raw milk cheeses (from cow, sheep, and goat milk), and their potential as probiotics and producers of bioactive compounds with health-promoting effects.

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Beneficial effects of Lactococcus lactis subsp. cremoris LL95 treatment in an LPS-induced depression-like model in mice

Cited by 15 publications

References 52 publications

Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice

Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions

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