Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease

Wong, Vincent Wai‐Sun; Wong, Grace Lai–Hung; Chan, Randolph C. H.; Shu, Sally She‐Ting; Cheung, Bernice; Li, Liz Sin; Chim, Angel Mei‐Ling; Chan, Carmen Ka-Man; Leung, Julie Ka-Yu; Chu, Winnie C.W.; Woo, Jean; Chan, Henry Lik‐Yuen

doi:10.1016/j.jhep.2018.08.011

Cited by 245 publications

(237 citation statements)

References 34 publications

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“…Importantly, baseline BMI influences the likelihood of NAFLD resolution (assessed by MRS), with a 3-5% body weight reduction sufficient for resolution in 50% of non-obese individuals, compared to the 7-10% body weight reduction required to achieve a similar outcome in obese individuals. 11 Thus, less weight loss may be required for non-obese individuals undergoing lifestyle therapy.…”

Section: Lifestyle-induced Weight Lossmentioning

confidence: 99%

Lifestyle modification in NAFLD/NASH: Facts and figures

2019

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The development of non-alcoholic fatty liver disease is closely linked to lifestyle factors, namely excessive caloric intake coupled with reduced physical activity and exercise. This review aims to examine the evidence behind lifestyle change as a tool to improve hepatic steatosis and liver histology in patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. Furthermore, potential barriers to adopting lifestyle changes and strategies to overcome these barriers in the clinical setting are discussed.

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Section: Lifestyle-induced Weight Lossmentioning

confidence: 99%

Lifestyle modification in NAFLD/NASH: Facts and figures

2019

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“…Importantly, remission of NAFLD was achieved in 67% of non-obese patients after lifestyle intervention. Furthermore, for half of all NAFLD patients enrolled in the study, a weight reduction of only 3-5% was effective in treating the disease [48].…”

Section: Dietary Changes and Physical Activity In Nashmentioning

confidence: 99%

New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis

et al. 2020

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The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Globally, it is currently the most common liver disease and is estimated to affect up to 25% of the population. In the first stage, NAFLD is characterized by simple hepatic steatosis (NAFL, nonalcoholic fatty liver) that might progress to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis or hepatocellular carcinoma. In this review, we discuss the global burden of NAFLD, together with future perspectives on how this epidemic could be restrained. There is also an urgent need for the development of new medical strategies for NAFLD patients. We aim to present the beneficial effects of life-style modifications that should be advised to both non-obese and obese NAFLD patients. Since there are currently no medications directly used for the treatment of more advanced NAFLD stages, the central part of this review summarizes ongoing and recently completed clinical trials testing promising drugs for NASH resolution. The marketing of new therapeutic agents would greatly increase the odds of reducing the global burden of NAFLD.

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“…A different approach was taken by Wong et al investigating lifestyle changes in an Asian population that was considered non-obese and exhibited NAFLD (so-called lean NAFLD) [4]. Half of these patients exhibited a BMI below 25 kg/m 2 .…”

Section: Studies On Dietary Interventionsmentioning

confidence: 99%

“…In 70% of patients a remission of NAFLD was seen after a weight reduction of 5-7%. Therefore, a weight loss of 5-10% from lifestyle changes appear to effectively lead to the resolution of hepatic steatosiseven in (Asian) patients with a BMI below 25 kg/m 2 [4]. The Mediterranean diet, which is rich in monounsaturated fats, fruits, vegetables, nuts, and low in processed foods, as well as red meat, has been studied extensively in cardiovascular disease, and also in obesity, as well as NAFLD [5].…”

Section: Studies On Dietary Interventionsmentioning

confidence: 99%