Beneficial Effects of Ozone Therapy on Oxidative Stress, Cardiac Functions and Clinical Findings in Patients with Heart Failure Reduced Ejection Fraction

Büyüklü, Mutlu; Kandemir, Fatih Mehmet; Set, Turan; Bakırcı, Eftal Murat; Değirmenci, Hüsnü; Hamur, Hikmet; Topal, Ergün; Küçükler, Sefa; Türkmen, Kültiğin

doi:10.1007/s12012-017-9400-8

Cited by 26 publications

(25 citation statements)

References 26 publications

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“…The systemic application only means ozone autohemotherapy (OAHT). Studies have found that ozone can induce and activate the body's antioxidant enzyme system to produce superoxide dismutase (SOD), which can remove part of the free radicals produced in the inflammatory reaction and interfere with the inflammatory factors produced in the process of disease development [7]. In animal experiments, it has been found that low-dose ozone can improve the level of blood lipid and inhibit oxidative stress to alleviate the progress of atherosclerotic diseases [8].…”

Section: Introductionmentioning

confidence: 99%

Ozone autohemotherapy elevates PPAR-γ expression to lower blood lipid in treatment for psoriasis

Lü

Ding

Tang

et al. 2020

Preprint

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Background: Psoriasis is widely accepted as a metabolic syndrome with significantly abnormal lipid metabolism and high blood lipids keep patients in a persistent low level of inflammatory condition. Hyperlipidemia and associated inflammatory reaction are believed to be the major risk factors contributing to the onset and recurrence of psoriasis. Peroxisome proliferator activated receptor-gamma (PPAR-γ) can effectively control the blood lipid level and inhibit inflammatory reaction. Methods: Ozone autohemotherapy (OAHT) was applied to treat psoriatic patients. The psoriasis area and severity index (PASI) score and blood lipid level were used to evaluate the efficacy. PPAR-γ expression level and correlation analysis were used to determine the OAHT target involving psoriasis. Results: We found that OAHT significantly decreased patients’ PASI scores and lipid blood level. Furthermore, we found that PPAR-γ expression in CD4+ T cells from patients with psoriasis was significantly lower than healthy controls, furtherly, we detected PPAR-γ expression upregulated after treatment compared with before treatment. There, we performed the correlation analysis on PPAR-γ level and patients’ PASI scores or lipid blood level. These results suggested OAHT might obviously improve patients’ PASI scores and decrease lipid blood level by regulating PPAR-γ expression. Conclusions: We found that OAHT can attenuate the condition of psoriatic patients and lower blood lipid by inducing PPAR-γ expression, suggesting that OAHT is effective in treating psoriasis and is worthy of further evaluations for its clinical applications.

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Section: Introductionmentioning

confidence: 99%

Ozone autohemotherapy elevates PPAR-γ expression to lower blood lipid in treatment for psoriasis

Lü

Ding

Tang

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In fact, ozone was used for the first time to disinfect operating rooms in 1856 and subsequently for water treatment in 1860 34568. So far, data have shown that ozone could improve several diseases such as abscesses,910 acne,11 eczema,12 psoriasis,13 human immunodeficiency virus and acquired immune deficiency syndrome,14151617 fibromyalgia,18 arthritis,19 asthma,20 cancers,721 inflammation,22 cardiac disease,23 liver disorders,2425 uveitis,26 cystitis,27 chronic wounds,28 dyslipidemia,29 osteomyelitis,30 Raynaud’s disease,31 sepsis,32 and sinusitis 33…”

Section: Introductionmentioning

confidence: 99%

Ozone therapy: a potential therapeutic adjunct for improving female reproductive health

et al. 2019

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Ozone is emerging as a new adjunct therapeutic agent for female infertility. We here present a review of the literature, to date, pertaining to the effect of ozone therapy on tubal, ovarian, endometrial, and vaginal factors that could potentially affect female fertility. It also presents data pertaining to the relationship of ozone therapy on pelvic adhesion formation. Most data were performed on animals and very few human studies existed in the literature. Results suggested that ozone therapy could have beneficial effect on tubal occlusion, could protect from endometritis and vaginitis, might protect ovaries from ischemia and oocyte loss and finally might lead to less formation of pelvic adhesions. There is a critical need for human studies pertaining to ozone therapy, especially using safe methods of administration, such as transdermally or intravaginally, on female fertility.

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“… 10 Future effects can show O 3 therapy being used to treat heart failure. 11 Furthermore, there is growing evidence that O 3 can be used to treat DFUs. A study showed that O 3 treatment via rectal insufflation can improve glycemic index along with preventing oxidative stress in diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Ozone therapy for diabetic foot

et al. 2018

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Diabetic foot ulcers (DFU) are a burden to the diabetic community. With increasing medical bills, to unsuccessful treatment, those suffering from DFUs can use alternative therapeutics. First seen in the mid-1800s, ozone (O3) is thought to be unstable, due to inherent molecular nature. With the help of pharmaceutical science, various O3 treatments have flourished in the medical community to help those suffering from DFUs. Promising results are seen through numerous studies. Usually, a mixture of both O2 and O3 is seen in pressurized machines as administered to the foot ulcer. Foot ulcers, specifically DFUs, need to be assessed, cleaned, and treated as fast as possible for the fastest results. Results such as amputation can be seen if the foot is not attended to as soon as possible. With fast growing clinical trials in O3 therapy and quick administration of the O3, O3 therapy may be on the rise to be at the forefront of treating DFUs. Compelling evidence is seen in clinical trials, but more must be done to fully understand the role of O3 in DFUs.

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Beneficial Effects of Ozone Therapy on Oxidative Stress, Cardiac Functions and Clinical Findings in Patients with Heart Failure Reduced Ejection Fraction

Cited by 26 publications

References 26 publications

Ozone autohemotherapy elevates PPAR-γ expression to lower blood lipid in treatment for psoriasis

Ozone autohemotherapy elevates PPAR-γ expression to lower blood lipid in treatment for psoriasis

Ozone therapy: a potential therapeutic adjunct for improving female reproductive health

Ozone therapy for diabetic foot

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