Beneficial Effects of Periodontal Treatment on Metabolic Control of Hypercholesterolemia

Oz, S. Gul; Fentoğlu, Özlem; Kılıçarslan, Alpaslan; Güven, Gülay Sain; Tanrtover, Mine Durusu; Aykaç, Yaşar; Sözen, Tümay

doi:10.1097/smj.0b013e31802fa327

Cited by 52 publications

(43 citation statements)

References 39 publications

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“…These results do not agree with those of Oz et al (29), who assessed the influence of periodontal therapy on hypercholesterolemia metabolic control in patients with periodontitis and reported a significant reduction in TC and LDL compared with initial values.…”

Section: Discussioncontrasting

confidence: 56%

“…The patients in this study remained obese until the end of the experiment, suggesting that the reduction of these parameters is likely related to periodontal therapy. Considering that periodontitis can also alter lipid profile (11,30,31), its treatment may reduce some markers such as TC and LDL (29). In addition to treating periodontitis, the dentist should advise the patient about additional risk factors that may interfere with the disease or treatment results including diet, body weight, lifestyle, and environmental stress (32), and also emphasize that help from a physician and nutritionist will be very beneficial to the treatment, thus targeting obesity as well as periodontitis simultaneously (33).…”

Section: Discussionmentioning

confidence: 99%

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Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Zuza¹,

Barroso²,

Fabricio³

et al. 2016

Journal of Oral Science

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Periodontal treatment may improve the metabolic control of dyslipidemia. The aim of this study was to evaluate the lipid profile and high-sensitivity C-reactive protein (hs-CRP) levels in obese and non-obese patients undergoing periodontal therapy. Patients with generalized chronic periodontitis were divided into obese (n = 28) and non-obese groups (n = 26). The periodontal parameters (visible plaque index, gingival bleeding index, probing depth, clinical attachment level, and bleeding on probing), anthropometric measurements (body mass index, waist circumference, and body fat), and serum analyses (triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, fasting glucose, glycated hemoglobin, and hs-CRP) were measured at baseline and 90 days after periodontal treatment. The results showed that the obese subjects presented alterations in triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP at baseline when compared with non-obese patients (P < 0.05). Periodontal treatment could improve the periodontal parameters in both groups similarly (P > 0.05). Obese subjects showed a significant decrease in the levels of triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP post-therapy (P < 0.05), while non-obese patients showed improvement only in hs-CRP (P < 0.05). In conclusion, periodontal treatment could improve the periodontal parameters and circulating hs-CRP in obese and non-obese subjects. Lipid profile was modified only in obese patients post-therapy. (J Oral Sci 58, [423][424][425][426][427][428][429][430] 2016)

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Zuza¹,

Barroso²,

Fabricio³

et al. 2016

Journal of Oral Science

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“…Losche et al (2005) did not observe alterations in total cholesterol, LDL, HDL, or TGs following therapy, while Oz (Oz et al 2007) and Duan (Duan et al 2009) found that total cholesterol and LDL levels decreased. Montebugnoli observed decreased circulating oxLDL levels following intensive periodontal therapy (Montebugnoli et al 2005).…”

Section: Dyslipidemia Lipid Peroxidation and Inflammationmentioning

confidence: 99%

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Schenkein

Loos

2013

Journal of Periodontology

177

120

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Inflammatory mechanisms linking periodontal diseases to cardiovascular diseasesSchenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. AbstractAims: In this article, inflammatory mechanisms that link periodontal diseases to cardiovascular diseases are reviewed. Methods: This article is a literature review. Results: Studies in the literature implicate a number of possible mechanisms that could be responsible for increased inflammatory responses in atheromatous lesions due to periodontal infections. These include increased systemic levels of inflammatory mediators stimulated by bacteria and their products at sites distant from the oral cavity, elevated thrombotic and hemostatic markers that promote a prothrombotic state and inflammation, cross-reactive systemic antibodies that promote inflammation and interact with the atheroma, promotion of dyslipidemia with consequent increases in pro-inflammatory lipid classes and subclasses, and common genetic susceptibility factors present in both disease leading to increased inflammatory responses. Conclusions: Such mechanisms may be thought to act in concert to increase systemic inflammation in periodontal disease and to promote or exacerbate atherogenesis. However, proof that the increase in systemic inflammation attributable to periodontitis impacts inflammatory responses during atheroma development, thrombotic events or myocardial infarction or stroke is lacking.

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“…When one single study (Oz et al 2007) was removed from the data, the heterogeneity reduced (p < 0.65, I squared of 0.00).…”

Section: Periodontal Treatment and Cvd Outcomes S87mentioning

confidence: 99%

“…Two RCTs (D'Aiuto et al 2005(D'Aiuto et al , 2006) examined a sample of otherwise healthy individuals affected by severe generalized periodontitis and showed that non-surgical periodontal treatment caused reductions in total and LDL-C levels at 2 and 6 months follow-up. In another RCT, Oz et al (2007) performed periodontal treatment in 50 individuals also suffering from hypercholesterolemia and evaluated their serum lipid concentrations 3 months after the treatment. There was a substantial decline in TC and LDL-C profiles in the treatment group and between the two groups.…”

Section: Periodontal Treatment and Cvd Outcomes S87mentioning

confidence: 99%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

128

137

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Evidence that periodontal treatment improves biomarkers and CVD outcomes D'Aiuto F, Orlandi M, Gunsolley JC. Evidence that periodontal treatment improves biomarkers and CVD outcomes. AbstractAim: The aim of this review was to critically appraise the evidence on the impact of periodontal treatment of cardiovascular diseases (CVDs) biomarkers and outcomes. Methods: A systematic search was performed in Cinhal, Cochrane, Embase and Medline for relevant articles up to July 2012. Duplicate screening and reference hand searching were performed. Data were then summarized and evidence graded in tables. Results: The search resulted in: (a) no evidence on the effects of periodontal therapy on subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractant protein-1, (b) limited evidence on the effects of periodontal therapy on arterial blood pressure, leucocyte counts, fibrinogen, tissue necrosis factor-a, sE-selectin, von Willebrand factors, d-dimers, matrix metalloproteinases, oxidative stress and CVD events, and (c) moderate evidence suggesting a negligible effect of periodontal therapy in reducing interleukin-6 and lipids levels, whilst a positive effect in reducing serum C-reactive protein levels and improving endothelial function. Conclusions: Periodontal therapy triggers a short-term inflammatory response followed by (a) a progressive and consistent reduction of systemic inflammation and (b) an improvement in endothelial function. There is however limited evidence that these acute and chronic changes will either increase or reduce CVD burden of individuals suffering from periodontitis in the long term.

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Beneficial Effects of Periodontal Treatment on Metabolic Control of Hypercholesterolemia

Abstract: The present study indicates that periodontitis causes changes in total and LDL cholesterol levels and local periodontal treatment resulted in a significant decrease in these markers. These results suggest a potential effect of periodontitis-driven systemic inflammation on lipid metabolism.

Cited by 52 publications

References 39 publications

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Evidence that periodontal treatment improves biomarkers and CVD outcomes

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