Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

Kasprzak-Drozd, Kamila; Oniszczuk, Tomasz; Stasiak, Mateusz; Oniszczuk, Anna

doi:10.3390/ijms22073715

Cited by 105 publications

(73 citation statements)

References 160 publications

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“…In highbush blueberry fruits, 44 flavonoids were previously identified, which were represented by quercetin and myricitin glycosides and chlorogenic acid [ 29 , 53 ]. The sugar part in the identified flavonoid glycosides from fruits was represented by glucose, galactose and arabinose [ 54 ], which corresponds to the results of our studies conducted for its leaves.…”

Section: Discussionsupporting

confidence: 73%

Highbush Blueberry (Vaccinium corymbosum L.) Leaves Extract and Its Modified Arginine Preparation for the Management of Metabolic Syndrome—Chemical Analysis and Bioactivity in Rat Model

et al. 2021

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Growing blueberry (Vaccinium corymbosum L., Highbush blueberry) as a berry crop is developing dynamically, especially in warm temperate, subtropical, and tropical regions of the world. When blueberry is cultivated on plantations, the bushes are pruned annually, and tons of leaves become waste. Thus, the aim of the present study was to create a preparation from blueberry leaves, study their chemical composition and determine their potential as a dietary supplement for the prophylactic and correction of the metabolic syndrome. Several schemes for obtaining extracts from blueberry leaves have been developed, including one with addition of arginine. A total of 18 phenolic substances were identified and quantified in the extracts by TLC and HPLC methods. Chlorogenic acid, hyperoside, and rutin were shown to be dominating constituents. Quantitative determination of hydroxycinnamic acid derivatives, flavonoids and other phenolics in the extracts was performed by spectrophotometric method. The extracts administration led to a significant decrease in the level of glucose, insulin and triacylglycerols in blood serum of adult mature inbred rats with insulin resistance induced by the fructose-enriched diet. The most promising one was the extract modified with arginine. The determined hypoglycemic and hypolipidemic activity of chemically standardized extracts from highbush blueberry leaves indicate the potential of this crop residue in utilization as a dietary supplement recommended in prevention of ailments associated with metabolic syndrome.

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Section: Discussionsupporting

confidence: 73%

Highbush Blueberry (Vaccinium corymbosum L.) Leaves Extract and Its Modified Arginine Preparation for the Management of Metabolic Syndrome—Chemical Analysis and Bioactivity in Rat Model

et al. 2021

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“…In these times of more and more common civilization diseases, to a large extent attributable to an unhealthy lifestyle marked by stress, environmental pollution and improper nutrition, people are looking for food products that replace synthetic ingredients with natural counterparts [ 1 , 2 ]. It is known that some foods can offer other beneficial effects on top of supplying the most essential nutrients.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases

Kasprzak-Drozd

Oniszczuk

Soja

et al. 2021

IJMS

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Epidemiological studies have emphasized the association between a diet rich in fruits and vegetables and a lower frequency of occurrence of inflammatory-related disorders. Black chokeberry (Aronia melanocarpa L.) is a valuable source of biologically active compounds that have been widely investigated for their role in health promotion and cardiovascular disease prevention. Many in vitro and in vivo studies have demonstrated that consumption of these fruits is associated with significant improvements in hypertension, LDL oxidation, lipid peroxidation, total plasma antioxidant capacity and dyslipidemia. The mechanisms for these beneficial effects include upregulation of endothelial nitric oxide synthase, decreased oxidative stress, and inhibition of inflammatory gene expression. Collected findings support the recommendation of such berries as an essential fruit group in a heart-healthy diet. The aim of this review was to summarize the reports on the impact of black chokeberry fruits and extracts against several cardiovascular diseases, e.g., hyperlipidemia, hypercholesterolemia, hypertension, as well as to provide an analysis of the antioxidant and anti-inflammatory effect of these fruits in the abovementioned disorders.

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“…Diosmetin mainly inhibited the growth of Bacillus spp. and Helicobacter pylori [ 54 ]. Based on these results and the related reports about the bioavailability and biological activity of related ingredients, it can be expected that Cirsium species, especially CJF, have similar pharmacological activities, such as hepatoprotection and the potential to be developed into functional products with biological activity for therapeutic use.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effects and Phytochemical Properties of Seven Taiwanese Cirsium Species Extracts

et al. 2021

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In the present investigation, we compared the radical-scavenging activities and phenolic contents of seven Taiwanese Cirsium species with a spectrophotometric method. We further analyzed their phytochemical profiles with high-performance liquid chromatography–photodiode array detection (HPLC–DAD). We found that the flower part of Cirsium japonicum var. australe (CJF) showed the best radical-scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and the hypochlorite ion, for which the equivalents were 6.44 ± 0.17 mg catechin/g, 54.85 ± 0.66 mmol Trolox/g and 418.69 ± 10.52 mmol Trolox/g respectively. CJF also had the highest contents of total phenolics (5.23 ± 0.20 mg catechin/g) and phenylpropanoids (29.73 ± 0.72 mg verbascoside/g). According to the Pearson’s correlation coefficient, there was a positive correlation between the total phenylpropanoid content and ABTS radical-scavenging activities (r = 0.979). The radical-scavenging activities of the phenylpropanoids are closely related to their reducing power (r = 0.986). HPLC chromatograms obtained in validated HPLC conditions confirm that they have different phytochemical profiles by which they can be distinguished. Only CJF contained silicristin (0.66 ± 0.03 mg/g) and silydianin (9.13 ± 0.30 mg/g). CJF contained the highest contents of apigenin (5.56 ± 0.09 mg/g) and diosmetin (2.82 ± 0.10 mg/g). Among the major constituents, silicristin had the best radical-scavenging activities against DPPH (71.68 ± 0.66 mg catechin/g) and ABTS (3.01 ± 0.01 mmol Trolox/g). However, diosmetin had the best reducing power and radical-scavenging activity against the hypochlorite anion (41.57 ± 1.14 mg mmol Trolox/g). Finally, we found that flavonolignans (especial silicristin and silydianin) and diosmetin acted synergistically in scavenging radicals.

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Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

Cited by 105 publications

References 160 publications

Highbush Blueberry (Vaccinium corymbosum L.) Leaves Extract and Its Modified Arginine Preparation for the Management of Metabolic Syndrome—Chemical Analysis and Bioactivity in Rat Model

Highbush Blueberry (Vaccinium corymbosum L.) Leaves Extract and Its Modified Arginine Preparation for the Management of Metabolic Syndrome—Chemical Analysis and Bioactivity in Rat Model

The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases

Antioxidant Effects and Phytochemical Properties of Seven Taiwanese Cirsium Species Extracts

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