Beneficial effects of Plantago albicans on high-fat diet-induced obesity in rats

Samout, Noura; Ettaya, Amani; Bouzenna, Hafsia; Ncib, Sana; Elfeki, Abdelfattah; Hfaïedh, Najla

doi:10.1016/j.biopha.2016.10.105

Cited by 18 publications

(13 citation statements)

References 25 publications

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“…Relatively, benefits of antioxidants for obesity therapy involving inhibition of adipogenesis-inducing factors like lipid peroxidation and inflammatory cascades are suggested [16,17,18]. Coincidently, associations between anti-oxidation in a lipophilic study model, reduction of TBARS production, and anti-adipogenic effects in animal study models of Nelumbo nucifera [19] and Plantago albicans extract [20] have been reported. Recently, Udomkasemsab, et al [21] revealed the interesting capacity of Antidesma bunius fruit extract in improving of glucose metabolism, triglyceride levels, and splenic lesions in high-fat diet-induced hypercholesterolemic rats that involved amelioration of oxidative stress and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Phenolic Profile, Antioxidant Activity, and Anti-obesogenic Bioactivity of Mao Luang Fruits (Antidesma bunius L.)

Krongyut

Sutthanut

2019

Molecules

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To investigate the anti-obesity potential of Antidesma bunius L. (MM), a Thai local fruit which is named “Mao Luang,” we have focused on the effects on pancreatic α-amylase and lipase enzyme activity and on adipocyte life cycle using the 3T3-L1 cell line as a model. In addition, the phytochemical composition and anti-oxidation potential were also analyzed using HPLC-PDA UV and colorimetric methods. The ethanolic extract of MM fruits prepared by a maceration method was used in the experiments. MM extract, yield 12.08% w/w, is composed primarily of phenolics and anthocyanins as the major phytochemicals, among which, gallic acid, catechin, anthocyanin-3-glucoside, and protocatechuic acid were initially identified. In addition, susceptibly inhibitory effects on oxidation in a DPPH assay; on lipase enzyme activity rather than amylase enzyme; and on adipocyte adipogenesis of MM were demonstrated. Interestingly, a concentration-dependent bi-modular manner of activity on adipocyte adipogenesis was discovered, whereby a significant anti-adipogenic effect was demonstrated at high concentration, whilst low concentrations of MM showed adipogenic induction. Lipolytic induction was manifested. Conclusively, the ethanolic MM extract was discovered to be a potential anti-obesity agent contributed by inhibitory effects on lipase enzyme and anti-differentiation and -adipogenesis in adipocytes which significantly correlated to the total phenolics content, as well as anti-oxidation as the mechanism of action. Nevertheless, to achieve effective application, further investigation in in vivo models should be considered.

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Section: Discussionmentioning

confidence: 99%

Phenolic Profile, Antioxidant Activity, and Anti-obesogenic Bioactivity of Mao Luang Fruits (Antidesma bunius L.)

Krongyut

Sutthanut

2019

Molecules

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“…Analyses on adipose, muscle and liver tissues demonstrated differing ability to scavenge free radicals and protection against lipid peroxidation (Ooi et al, 2018). Another polyphenol-rich extract from Plantago albicans reduced the BW, lipid accumulation in liver and heart tissue of DIO rats and improved the lipid profile, activating a panel of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) (Samout et al, 2016).…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…Plant species (incl. plant organ and extract) insulin resistance; decreased TNF-α, IL-6 and increased adiponectin in serumJang et al, 2017 Arctium lapa L (fruits, 70% ethanolic) and adipose tissue mass; reduction of TG and LDL-C; suppression of C/ EBPα and PPARγ; activation of AMPK and UCP1Han et al, 2016 Cinnamomum cassia Presl (cortex, aqueous) of glucose and insulin; decreased hepatic TG, TC, LDL-C and ALT; suppressed lipid accumulation; decreased adipocyte size and increased muscle massSong et al, 2017aSong et al, ,2017b Cirsium setidens Nakai (leaves, ethanolic) of TG, TC and LDL-C; decreased adipocytes differentiation; downregulation of C/EBPα, PPARγ, FABP4, SREBP-1 and FAS; up-regulation of adiponectin and glucose, serum insulin, leptin and hepatic lipid levels; attenuation of hyperlipidemia (down-regulation of FAS, SREBP-1, SREBP-2); inhibition of ACC1 and PPARγ; TG, TC and LDL-C; up-regulation of PPARα in liver; down-regulation of PPARγ in liver and adipose tissue; down-regulation of TNF-α in adipose tissueYang et al, 2017 Lysimachia foenum-graecum Hance (whole plant, ethanolic) insulin resistance; reduced inflammatory cytokines (IL-6 and IL-1β) and reduced levels of PPARγ and C/EBPα in fat tissueSeo et al, 2011 Melissa officinalis L (leaves, aqueous ethanol) TG, TC and LDL-C; decreased levels of ACC1, SCD1, SREBP-1; inhibition of C/EBPα, PPARγ and perilipinAhn and Go, 2017 Platango albicans L (leaves, dichloromethane) 300 7 13.68 Decreased TG, TC and LDL-C in serum; increased antioxidant enzymes SOD, CAT and GSH-PxSamout et al, 2016 Polygala tenuifolia Willd (roots, aqueous) insulin sensitivity (decreased blood glucose and plasma insulin levels); increased anti-inflammatory cytokines (IL-2, IL-4, IL-10) and reduced pro-inflammatory cytokines (IL-12, TNF-α, KC/GRO); decreased levels of TG, TC and LDLlevels of (TG, TC and LDL-C); down-regulated C/EBPα, PPARγ, FABP4 and ACC; upregulated adiponectin and CPT-1Jung et al, 2016b Vitis vinifera L (seeds, hydroalcoholic)200 12…”

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confidence: 99%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

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Diverse groups of factors are leading to increased weight gain and obesity, such as certain genetic phenotypes, neuroendocrine disturbances, the administration of some drugs, behavioral, social and environmental factors. The progressively escalating rates of overweight and obesity worldwide have led to an introduction of a new term "globesity". Excessive accumulation of body fat and especially of visceral adipose tissue is the main predisposing factor for the development of metabolic syndrome and other obesity related co-morbidities. At the present moment only few pharmacotherapeuticals are used for long-term treatment of obesity acting on narrow target spectra, e.g. pancreatic and gastric lipase inhibition, acting as adrenomimetics or activating the satiety centers in hypothalamus. Plant-based medications that accelerate weight loss, proved to be safe, effective and widely available, would be a preferable alternative for anti-obesity treatments. As plant extracts are multi-component systems they could also act by more than one mechanism, including decreased lipid absorption, decreased energy intake, increased energy expenditure, decreased pre-adipocyte differentiation and proliferation, decreased lipogenesis and increased lipolysis. The current review gives a summary of the risk factors for obesity development and its characteristics consequences. Current treatment options, combining lifestyle changes and conventional treatment with commercial anti-obesity drugs have been described as well. Special emphasis on in vitro, in vivo and human studies, of potential medicinal plant extracts and phytochemicals, such as polyphenols, terpenoids, alkaloids, saponins, able to modulate the molecular pathways and gene/protein expressions related to obesity, have been highlighted.

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“…Another study used a water-based extract from the medicinal plant P. albicans to treat male Wistar rats, and the results showed that the body weight and the relative weight of the adipose tissue in the group treated with the extract were significantly lower (p<0.05) when compared with the untreated group. The study also showed that the group administered with P. albicans presented a significant decrease (p<0.05) in serum levels of triglycerides, total cholesterol, and LDL-C, and a significant increase in HDL-C. As for the antioxidant capacity of the formulation, EC 50 = 250±2.12 µg/mL was obtained in the DPPH test and EC 50 = 27.77±0.14 µg/mL in the FRAP test [26].…”

Section: Murinometric Analysismentioning

confidence: 73%

“…Due to the systemic and neurodegenerative problems arising from obesity, dyslipidemia, diabetes mellitus (DM) and metabolic syndrome (MS), several studies have observed the effect of bioactive compounds in rats submitted to highcalorie diets as experimental models. The biological effects in the experimental models were verified through studies with plant extracts (Prosthechea karwinskii [23], herbal extracts T1, T2 and T3 [24], Prosopis cineraria [25], Plantago albicans [26], as well as the use of Pinus sp. mushrooms.…”

Section: Murinometric Analysismentioning

confidence: 99%

Histological Evaluation of Brain Tissue in Dyslipidemic Rats Treated with Dietary Supplements Based on Amazonian Fruits

Carneiro

Freitas

Rodrigues

et al. 2021

EJMP

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Aims: By using histological analysis, the study aims to evaluate the effect of a nutraceutical based on the Amazonian fruits of camu-camu (Myrciaria dubia (Kunth) Mc Vaugh), acai (Euterpe precatoria Mart.) and guarana (Paullinia cupana) on the brain tissue (hippocampus) of dyslipidemic rats. Methodology: Preclinical trials were conducted using male and female rats (n=30) of the Wistar strain (Rattus norvegicus) that were randomly divided into five groups (G) (n=6). G1 was control, G2 was induced to obesity with consumption of experimental feed (hypercaloric and hyperlipidic), G3 was induced to obesity with consumption of experimental feed and treated with simvastatin (50 mg/kg/day), and G4 and G5, which were induced to obesity with the consumption of experimental feed and supplemented with 100 mg/kg/day and 200 mg/kg/day of the formulation, respectively. The study period was 72 days, and, for 37 days, induction to obesity was performed with the experimental feed (hypercaloric and hyperlipidic). During the following weeks, for 35 days, after division of the groups, certain groups received, in parallel, treatment with simvastatin (G3) or supplementation with the nutraceutical (G4 and G5). Subsequently, histological slides of the brain tissue stained with violet cresyl were elaborated, photographed and analyzed. Results: No significant differences were observed between the mean of intact neurons among the experimental groups induced to obesity. The neurotoxic effect, evidenced by the significant difference between the mean of intact neurons between the control group and obesity-induced groups, corroborates the findings of neuronal damage and degenerative processes reported in the literature. Conclusion: The nutraceutical based on Amazonian fruits was not able to prevent the neurotoxic effect arising from the hyperlipidic and hypercaloric diet, and therefore did not present a neuroprotective effect in Wistar rats under the conditions established in the experiment.

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Beneficial effects of Plantago albicans on high-fat diet-induced obesity in rats

Cited by 18 publications

References 25 publications

Phenolic Profile, Antioxidant Activity, and Anti-obesogenic Bioactivity of Mao Luang Fruits (Antidesma bunius L.)

Phenolic Profile, Antioxidant Activity, and Anti-obesogenic Bioactivity of Mao Luang Fruits (Antidesma bunius L.)

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Histological Evaluation of Brain Tissue in Dyslipidemic Rats Treated with Dietary Supplements Based on Amazonian Fruits

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