Beneficial Effects of Plasma Rich in Growth Factors (PRGF) Versus Autologous Serum and Topical Insulin in Ocular Surface Cells

Anitua, Eduardo; Fuente, María de la; Sánchez-Ávila, RM; Merayo‐Lloves, Jesús; Muruzábal, Francisco

doi:10.1080/02713683.2023.2173237

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…Interestingly, a recent culture study with ocular surface cells showed that drops from plasma rich in growth factors were superior to topical insulin at two different concentrations (1 and 0.2 IU/m) in promoting wound healing and reducing the fibrosis process [ 115 ]. Currently, no universal protocol exists regarding treatment with topical insulin, as studies apply different preparation methods, dosages, concentrations, and types of drops [ 116 , 117 ].…”

Section: The Role Of Insulin and Effect Of Diabetesmentioning

confidence: 99%

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

Woronkowicz,

Roberts,

Skopiński

2024

Biology

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The corneal epithelium, comprising three layers of cells, represents the outermost portion of the eye and functions as a vital protective barrier while concurrently serving as a critical refractive structure. Maintaining its homeostasis involves a complex regenerative process facilitated by the functions of the lacrimal gland, tear film, and corneal nerves. Crucially, limbal epithelial stem cells located in the limbus (transitional zone between the cornea and the conjunctiva) are instrumental for the corneal epithelium integrity by replenishing and renewing cells. Re-epithelialization failure results in persistent defects, often associated with various ocular conditions including diabetic keratopathy. The insulin-like growth factor (IGF) system is a sophisticated network of insulin and other proteins essential for numerous physiological processes. This review examines its role in maintaining the corneal epithelium homeostasis, with a special focus on the interplay with corneal limbal stem cells and the potential therapeutic applications of the system components.

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Section: The Role Of Insulin and Effect Of Diabetesmentioning

confidence: 99%

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

Woronkowicz,

Roberts,

Skopiński

2024

Biology

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“…In addition to the abovementioned treatments, modern DED treatments incorporate nonpharmacological, natural products and substances such as ectoine [39][40][41] and blood-derived products [42][43][44][45][46][47] to manage superficial ocular inflammation.…”

Section: Other Nonpharmacological Approaches To Managing Tear Film Dy...mentioning

confidence: 99%

“…In cases where symptoms are severe, an OA flare-up occurs, or the patient develops concomitant allergic rhinitis symptoms, including platelet-rich plasma, plasma rich in growth factors, and autologous serum [42][43][44][45][46][47]. However, the available evidence on the efficacy of these compounds is not consistent, as a meta-analysis pooling 19 clinical trials demonstrated similar efficacy of blood therapy to artificial tears [44].…”

Section: Managing Ocular Allergy When Dry Eye Disease Is Already Esta...mentioning

confidence: 99%

“…However, the available evidence on the efficacy of these compounds is not consistent, as a meta-analysis pooling 19 clinical trials demonstrated similar efficacy of blood therapy to artificial tears [44]. According to recent data, plasma rich in growth factors is more efficacious than autologous serum in reducing the signs and symptoms of DED [42]. For this reason, more robust studies are required to assess the sustainability and applicability of blood derivatives in managing DED and complementary therapy in other ocular diseases such as allergic conjunctivitis.…”

Section: Managing Ocular Allergy When Dry Eye Disease Is Already Esta...mentioning

confidence: 99%

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The Importance of Preventing and Managing Tear Dysfunction Syndrome in Allergic Conjunctivitis and How to Tackle This Problem

Montero-Iruzubieta,

Sanchez Hernandez,

Dávila

et al. 2023

J Investig Allergol Clin Immunol

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Tear dysfunction syndrome, also known as dry eye disease (DED), is a multifactorial disease of the ocular surface characterized by the loss of tear film homeostasis. DED shows a significant clinical overlap with ocular allergy (OA), which alters tear film homeostasis, thus predisposing the patient to DED. Both conditions constitute the most common ocular surface disorders and have a potentially severe impact on patients’ quality of life. Clinical practice guidelines recommend topical therapies as first-line treatment for OA. However, eye drop formulations may contain additional substances that can contribute to ocular surface damage and the development of DED. Therefore, physicians treating ocular allergy should be aware of problems affecting the tear film, the role of tear film disruption in OA, and topical treatment to prevent or minimize DED. The aim of this review is to present an updated overview of the topic.

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Effects of injectable platelet-rich fibrin (i-PRF) on pterygium surgery with conjunctival autograft

Bahar,

Sabur

2024

Int Ophthalmol

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Beneficial Effects of Plasma Rich in Growth Factors (PRGF) Versus Autologous Serum and Topical Insulin in Ocular Surface Cells

Cited by 9 publications

References 33 publications

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

The Importance of Preventing and Managing Tear Dysfunction Syndrome in Allergic Conjunctivitis and How to Tackle This Problem

Effects of injectable platelet-rich fibrin (i-PRF) on pterygium surgery with conjunctival autograft

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