Beneficial effects of plasmapheresis before thymectomy on the outcome in myasthenia gravis

Nagayasu, Takeshi; Yamayoshi, Takatomo; Matsumoto, Keitaro; Ide, Noboru; Hashizume, Satoshi; Nomura, Motoyuki; Muraoka, Masashi; Tagawa, Tetsuzo; Akamine, Shinji; Oka, Teruaki

doi:10.1007/s11748-005-1001-y

Cited by 31 publications

(28 citation statements)

References 26 publications

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“…In patients with myasthenia gravis, which included 16 patients, the improvement rate was 81.25%. This was in agreement with studies done by Nagayasu et al [14], who stated remission rate at (79%), and Sarkar et al [15] who stated remission rate of 80%. The difference at improvement rate could be attributed to the total number of cases studied.…”

Section: Discussionsupporting

confidence: 93%

Outcomes of Therapeutic Plasma Exchange; One Year Single Center Experience

Ghonemy¹

2016

UNOAJ

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Background: Outcome of therapeutic plasma exchange (TPE) in treating different immunological and non-immunological diseases in our unit is not clear. We aimed to study the outcome TPE in different diseases categories during one-year period.Methods: Prospective cross sectional study of patients referred for TPE during one year period. Demographic, clinical data, number of sessions, volume of plasma exchanged, patient tolerance and complications during or post to the procedure were systematically recorded and descriptive statistics applied for analysis.

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Section: Discussionsupporting

confidence: 93%

Outcomes of Therapeutic Plasma Exchange; One Year Single Center Experience

Ghonemy¹

2016

UNOAJ

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“…Yeh et al [8] and Nagayasu et al [9] suggested that preoperative plasmapheresis may facilitate improved outcomes of patients with myasthenia gravis after thymectomy; however our study showed that the post-operative outcome was not different between the two groups. There was no difference in immediate post-operative extubation time, length of hospital stay, and 30-day mortality.…”

Section: Discussioncontrasting

confidence: 86%

Preoperative Plasmapheresis for Elective Thymectomy in Myasthenia Patient: Is It Necessary?

et al. 2013

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Background. Role of plasmapheresis before thymectomy remains controversial. The aim of this study is to determine the peri-operative and post-operative outcome of a thymectomy between performing and not performing a pre-operative plasmaphreresis. Patients and Methods. A retrospective chart review study was conducted in Chiang Mai University Hospital between January 2006 and December 2011. There were 86 myasthenia patients divided into two groups; Preoperative plasmapheresis group (PPG) and no preoperative plasmapheresis group (NPPG). The primary outcome involved post-operative extubation and the secondary outcome included post-operative complications, 28 day mortality and length of hospital stay. Results. Eighty-six patients were enrolled in this study. The number of patients who had a history of myasthenic crisis at any time or within one month in the PPG was significantly more than those in the NPPG. Muscle power and forced expiratory vital capacity in the NPPG was higher than that in the PPG. The postoperative extubation rate was similar in both groups. After controlling for the propensity score, there were no statistically significant differences in both of primary and secondary outcomes. Conclusion. The results of this study shows no significant differences between both groups in all outcomes, therefore the pre-operative plasmaphresis is not necessary for elective thymectomy.

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“…Disease‐modifying therapies for MG include immunosuppression with oral prednisone (PSL), azathioprine, cyclosporine, or tacrolimus . More aggressive exacerbation of MG often requires additional immunomodulatory treatment with plasma exchange/plasmapheresis (PE/PP) and/or intravenous immunoglobulin (IVIg) …”

mentioning

confidence: 99%