Beneficial Effects of Probiotics, Prebiotics, Synbiotics, and Psychobiotics in Inflammatory Bowel Disease

Wasilewski, Andrzej; Zielińska, Marta; Storr, Martin; Fichna, Jakub

doi:10.1097/mib.0000000000000364

Cited by 148 publications

(90 citation statements)

References 98 publications

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“…IBD and COPD share common pathology relating to mucosal barrier disruption including an altered microbiome, immune dysfunction, altered epithelial cell function, and chronic inflammation [31, 41, 42]. Live microbial products are currently being tested for efficacy in IBD [43, 44]. Furthermore, a product that is prepared in a similar manner to KB, but produced from Escherichia coli, has shown evidence of efficacy in IBD patients [45] and is currently being investigated in clinical trials as a treatment for IBD.…”

Section: Discussionmentioning

confidence: 99%

Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation

Bazett¹,

Biala

Huff

et al. 2017

Respir Res

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BackgroundCigarette smoke exposure is the major risk factor for developing COPD. Presently, available COPD treatments focus on suppressing inflammation and providing bronchodilation. However, these options have varying efficacy in controlling symptoms and do not reverse or limit the progression of COPD. Treatments strategies using bacterial-derived products have shown promise in diseases characterized by inflammation and immune dysfunction. This study investigated for the first time whether a novel immunotherapy produced from inactivated Klebsiella (hereafter referred to as KB) containing all the major Klebsiella macromolecules, could attenuate cigarette smoke exposure-induced immune responses. We hypothesized that KB, by re-directing damaging immune responses, would attenuate cigarette smoke-induced lung inflammation and bronchoalveolar (BAL) cytokine and chemokine production.MethodsKB was administered via a subcutaneous injection prophylactically before initiating a 3-week acute nose-only cigarette smoke exposure protocol. Control mice received placebo injection and room air. Total BAL and differential cell numbers were enumerated. BAL and serum were analysed for 31 cytokines, chemokines, and growth factors. Lung tissue and blood were analysed for Ly6CHI monocytes/macrophages and neutrophils. Body weight and clinical scores were recorded throughout the experiment.ResultsWe demonstrate that KB treatment attenuated cigarette smoke-induced lung inflammation as shown by reductions in levels of BAL IFNγ, CXCL9, CXCL10, CCL5, IL-6, G-CSF, and IL-17. KB additionally attenuated the quantity of BAL lymphocytes and macrophages. In parallel to the attenuation of lung inflammation, KB induced a systemic immune activation with increases in Ly6CHI monocytes/macrophages and neutrophils.ConclusionsThis is the first demonstration that subcutaneous administration of a microbial-based immunotherapy can attenuate cigarette smoke-induced lung inflammation, and modulate BAL lymphocyte and macrophage levels, while inducing a systemic immune activation and mobilization. These data provide a foundation for future studies exploring how KB may be used to either reverse or prevent progression of established emphysema and small airways disease associated with chronic cigarette smoke exposure. The data suggest the intriguing possibility that KB, which stimulates rather than suppresses systemic immune responses, might be a novel means by which the course of COPD pathogenesis may be altered.Electronic supplementary materialThe online version of this article (doi:10.1186/s12931-017-0577-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation

Bazett¹,

Biala

Huff

et al. 2017

Respir Res

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“…2 Probiotics have been used in several disorders in populations ranging from infants to the elderly. Studies have shown probiotics are helpful in several diseases, including AAD 2 , the induction and maintenance of inflammatory bowel disease remission 3 , vaginal health 4 , necrotizing enterocolitis 5 , and nonalcoholic fatty liver disease. 6 However, a recent systematic review suggests that most probiotic strains may not prevent AAD in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

“…• competition for nutrients 2 • inhibition of epithelial/mucosal adherence of pathogens 2 • decreased colonic pH favoring the growth of nonpathogenic species 2 • defense against bacteriophages 3 • reduction of acute immune responses 3 …”

Section: Mechanism Of Actionmentioning

confidence: 99%

Prophylaxis and treatment of antibiotic-associated diarrhea: is there evidence for using probiotics?

2015

SWRCCC

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“…Experimental data and human studies have shown beneficial effects of prebiotic supplementation in different pathological conditions, including some gastrointestinal diseases such as liver diseases, IBD and chronic constipation[15–17]. However, there is no consensus on the therapeutic efficacy of prebiotics in IBS[18].…”

Section: Introductionmentioning

confidence: 99%

Isomalto-oligosaccharides ameliorate visceral hyperalgesia with repair damage of ileal epithelial ultrastructure in rats

et al. 2017

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BackgroundTreatment of irritable bowel syndrome (IBS) with probiotics has achieved effectiveness to a certain extent. Whether prebiotics will work is still unclear. This study aimed to investigate the therapeutic effects of the prebiotic isomalto-oligosaccharides (IMO) on visceral hypersensitivity (VHS) in rats and to explore potential mechanism.MethodsWater avoidance stress (WAS) was used to induce VHS in rats. The score for the abdominal withdrawal reflex (AWR) was determined while colorectal distension and compared between VHS group and control group in order to validate VHS preparation. Rats with VHS were then divided into an IMO-treated group (intragastric 5% IMO, 2 mL/d, 14 days) and a water-control group (intragastric water). After treatment, AWR score and intestinal transit rate (ITR) were determined, stool culture was performed, the ultrastructure of the ileum epithelium was observed with scanning electron microscopy (SEM), and serum cytokines were measured.ResultsWAS significantly increased AWR score responding to colorectal distension, and lowered the pain threshold. IMO treatment improved VHS with a reduction in AWR score on graded colorectal distension and an increase in pain threshold. SEM showed damages on the ileal epithelial ultrastructure in VHS rats, which was attenuated by IMO treatment. ITR, fecal microbiota and serum cytokine levels were comparable among control group, water-control group, and IMO-treated rats.ConclusionIn this randomized placebo-controlled study, the results showed that IMO ameliorated WAS-induced visceral hyperalgesia in rats, this effect may be attributed to the repair of damages on intestinal epithelial ultrastructure.

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Beneficial Effects of Probiotics, Prebiotics, Synbiotics, and Psychobiotics in Inflammatory Bowel Disease

Cited by 148 publications

References 98 publications

Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation

Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation

Prophylaxis and treatment of antibiotic-associated diarrhea: is there evidence for using probiotics?

Isomalto-oligosaccharides ameliorate visceral hyperalgesia with repair damage of ileal epithelial ultrastructure in rats

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