Beneficial effects of psyllium on the prevention and treatment of cardiometabolic diseases

Chen, Chen; Shang, Chang; Xin, Laiyun; Xiang, Ming; Wang, Yuling; Shen, Zihuan; Jiao, Linke; Ding, Fan; Cui, Xiangning

doi:10.1039/d2fo00560c

Cited by 14 publications

(7 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yamagishi et al (2023) reported that cellulose can mitigate neurodegeneration-related nerve inflammation and decrease the accumulation of βAP in the brain through intestinal bacteria which synthesize butter acid (as a result of dietary fiber fermentation, short-chain fatty acids, and phytosterols). McRorie (2015), Shah et al (2020) and Chen et al (2022) explain the improvement of neurometabolism by the unique viscous potential of Plantago psyllium, which refines the gut microbiome, has antibacterial properties and reduces the levels of cholesterol and glucose in the blood. However, Hansan et al (2017) believe that cellulose might stimulate neurometabolism by stimulating the function of the immune system, decreasing insulin resistance, enhancing glucose metabolism, and regulating the activity of erythrocytes.…”

Section: Discussionmentioning

confidence: 99%

Hippocampus and jejunum biochemical parameters related to physiological ageing of neurons in rats fed diets with copper nanoparticles and different fiber types

Krauze,

Juśkiewicz,

Fotschki

et al. 2024

Annals of Animal Science

View full text Add to dashboard Cite

One of the more important factors responsible for synaptic dysfunction of neurons is a neurological ageing. It is a natural consequence of occurrence of biochemical pathways in cells, promoting oxidation processes, an increase in the amount of free oxygen radicals that damage DNA, disorders in calcium ion homeostasis, interactions between lipids of cell membranes, formation of neurofibrillary tangles and deposition of toxic protein deposits. Diet modifications can delay neurometabolism disorders that occur as a result of aging, as well as limit the development of neurodegenerative diseases. The aim of this study on rats was to verify the hypothesis regarding the effect of dietary addition of copper nanoparticles (CuNPs; instead of standard CuCO3) in combination with various dietary fibers on changes in hippocampus and jejunum biochemical parameters related to metabolic disorders appearing with neurological ageing in rats. Male rats were fed a control diet with containing fiber α-cellulose and a standard or enhanced content of Cu provided as CuCO3 (6.5 or 13 mg/kg diet). The diets of other groups were deprived of CuCO3 and the animals were fed diets supplemented with two CuNPs aforementioned doses, and additionally combined with four different types of dietary fiber: α-cellulose (control fiber), pectin, inulin or psyllium (Plantago psyllium). The addition of dietary CuNPs increased the level of acetylcholinesterase (AChE) and decreased the levels of Tau protein, glycosylated AChE (GAChE) and Ca/calmodulin dependent protein kinase II alpha (CAMK2α) in the examined organs. To sum up, both applied doses of CuNPs, 6.5 mg and 13 mg per kg of a diet, can beneficially modulate some important parameters describing metabolic and neurodevelopmental status in the hippocampal and small intestinal tissue of rats. With regard to the fiber type added to rats’ diet, the Plantago psyllium fiber strengthened the mentioned effects of copper nanoparticles. The observed effects should be confirmed in a model study of neurodegeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Hippocampus and jejunum biochemical parameters related to physiological ageing of neurons in rats fed diets with copper nanoparticles and different fiber types

Krauze,

Juśkiewicz,

Fotschki

et al. 2024

Annals of Animal Science

View full text Add to dashboard Cite

show abstract

“…An explanation may be that dietary fibre naturally increases the feeling of satiety, consequently reducing the overall caloric intake [ 37 ]. The observed effects caused by inulin or psyllium may be related to the fact that both forms dissolve well in water, forming a gel in the small intestine, which prolongs the feeling of satiety, thus reducing the intake of energy and weight loss, or to the specific rheological properties of high-fibre foods that require longer chewing [ 40 ]. Adam et al [ 37 ] prove that soluble dietary fibre of a prebiotic nature stimulates the secretion of satiety hormones, such as glucagon-like peptide-1 (GLP-1) and tyrosine-tyrosine peptide (PYY), by the mucosa of the small intestine, which effectively suppresses appetite and reduces the food intake.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Copper Nanoparticles and a Different Source of Dietary Fibre in the Diet on the Integrity of the Small Intestine in the Rat

et al. 2023

View full text Add to dashboard Cite

The aim of the study was to verify the hypothesis regarding the effect of recommended (6.5 mg/kg) or enhanced (13 mg/kg) level of CuNPs in the diet in combination with different types of dietary fibre—cellulose (control), inulin, pectin or psyllium—on selected biological parameters of intestinal integrity in rats. Rats were randomly divided into 10 groups. The first two groups were fed a control diet that contained cellulose, and a mineral mixture with standard or enhanced content of CuCO3. Experimental groups were fed a diet supplemented with CuNPs (6.5 or 13 mg/kg) and combined with different types of fibre (cellulose, pectin, inulin or psyllium). After the feeding period, blood and small intestine samples were collected for further analysis. Replacing CuCO3 by CuNPs in the diet positively reduced the level of lactic acid and apoptosis markers in the small intestine; however, it also resulted in the intensification of DNA oxidation. The most beneficial effect on DNA repair mechanisms is related to inulin, while pectin has the greatest ability to inhibit inflammatory processes that induce the apoptotic death of cells in the small intestine. Our results suggest that dietary fibre supplementation protects the small intestine against potentially harmful, oxidative effects of CuNPs by intensifying the intestinal barrier.

show abstract

“…Side effects include gastrointestinal discomfort, mild anaphylactic allergic reactions, bowel obstructions, and esophageal obstructions [16,22,64]. Increased water consumption reduces obstructions [164].…”

Section: Psylliummentioning

confidence: 99%

Lipid-Lowering Nutraceuticals for an Integrative Approach to Dyslipidemia

Cheung

Sikand

Dineen

et al. 2023

JCM

View full text Add to dashboard Cite

Dyslipidemia is a treatable risk factor for atherosclerotic cardiovascular disease that can be addressed through lifestyle changes and/or lipid-lowering therapies. Adherence to statins can be a clinical challenge in some patients due to statin-associated muscle symptoms and other side effects. There is a growing interest in integrative cardiology and nutraceuticals in the management of dyslipidemia, as some patients desire or are actively seeking a more natural approach. These agents have been used in patients with and without established atherosclerotic cardiovascular disease. We provide an updated review of the evidence on many new and emerging nutraceuticals. We describe the mechanism of action, lipid-lowering effects, and side effects of many nutraceuticals, including red yeast rice, bergamot and others.

show abstract

Beneficial effects of psyllium on the prevention and treatment of cardiometabolic diseases

Abstract: Cardiometabolic diseases are reaching epidemic proportions worldwide. Nevertheless, current therapeutic strategies are insufficient; thus, studying novel complementary and alternative medicines remains of the upmost importance. Psyllium has been used for...

Cited by 14 publications

References 132 publications

Hippocampus and jejunum biochemical parameters related to physiological ageing of neurons in rats fed diets with copper nanoparticles and different fiber types

Hippocampus and jejunum biochemical parameters related to physiological ageing of neurons in rats fed diets with copper nanoparticles and different fiber types

The Effect of Copper Nanoparticles and a Different Source of Dietary Fibre in the Diet on the Integrity of the Small Intestine in the Rat

Lipid-Lowering Nutraceuticals for an Integrative Approach to Dyslipidemia

Contact Info

Product

Resources

About