Beneficial Effects of Renal Transplantation on Cardiovascular Disorders in Dialysis Patients

Nakajima, Kiyokazu; Ochiai, Takenori; Suzuki, Takao; Gunji, Yoshio; Asano, Tomohiko; Isono, Kaichi; Mikami, Yuji; Sakamoto, Kaoru; Kashiwabara, Hidehiko; Yamada, Katsushi

doi:10.1007/s005950050232

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…5 Follow-up of cardiac abnormalities in the adult patient with CKF and the modi cations these undergo after KT has been documented. Nakajima et al 6 found that successful KT improved systolic function, as quanti ed by fractional shortening and ejection fraction, and some of the patients of their series showed diminished left ventricular posterior wall thickness and systolic diameter. Peteiro et al performed studies on 30 patients who underwent KT and observed a signi cant decrease in left ventricular mass index (from 201 6 56 to 171 6 41 gr/m 2 body surface area [BSA]; P , 0.01), left ventricular end-diastolic volume index, and left ventricular diastolic diameter corrected for BSA.…”

Section: Discussionsupporting

confidence: 93%

The Effect of Kidney Transplant on Cardiac Function: An Echocardiographic Perspective

et al. 2001

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Kidney transplant (KT) resolves many of the cardiac abnormalities associated with chronic kidney failure (CKF). This study analyzed cardiac alterations of kidney failure and their modification with transplant. Thirteen patients in CKF underwent conventional echocardiograms, dobutamine stress echocardiograms, and injection of contrast to examine perfusion before KT and 3 months after transplant. Nine patients had evidence of left ventricular hypertrophy and six had evidence of diastolic dysfunction. Wall thickness, left ventricular mass, and mass index diminished after KT; only two patients continued to manifest hypertrophy. Left ventricular systolic diameters and volumes diminished at 3 months, and diastolic diameters after 4 months. Left ventricular fractional shortening and ejection fraction increased 3 months after transplant. At the end of the study, only two patients continued to show diastolic dysfunction. Dobutamine echocardiograms showed no segmental wall-movement abnormalities. Myocardial perfusion was normal before and after transplant. The results suggest that KT diminishes hypertrophy and improves left ventricular systolic and diastolic function. Echocardiography provides valuable information for detection and follow-up of cardiac abnormalities in patients with kidney disease. Evaluation of segmental wall movement and myocardial perfusion aid in demonstrating that our studied patients with CKF had no indirect signs of coronary artery disease.

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Section: Discussionsupporting

confidence: 93%

The Effect of Kidney Transplant on Cardiac Function: An Echocardiographic Perspective

et al. 2001

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“…Also an improvement in central arterial stiffness was observed after a year of follow-up [69,70]. This is in line with the other evidence that cardiac function in DM transplant candidates is carefully evaluated prior to transplantation and LV systolic, diastolic function and arterial compliance improves shortly after a successful renal transplant [71][72][73][74][75]. It was also concluded that assessment of arterial stiffness may improve pre-transplantation risk assessment both in donors and recipients [70].…”

Section: Risk In Kidney Transplanted Patientssupporting

confidence: 68%

Cardiovascular Risk Assessment in Diabetes and Chronic Kidney Diseases: A New Insight and Emerging Strategies

Khoshdel¹

2012

Cardiovascular Risk Factors

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“…Renal transplantation is associated with an all‐cause mortality benefit when compared to a similar population awaiting transplant, and this benefit is greatest among diabetic recipients (7). Renal transplantation may specifically improve cardiac function (8). However, it is not known whether transplantation also has a specific effect on cardiovascular morbidity.…”

Section: Introductionmentioning

confidence: 99%

Acute Coronary Syndromes after Renal Transplantation in Patients with End-Stage Renal Disease Resulting from Diabetes

Hypolite¹,

Bucci²,

Hshieh³

et al. 2002

American Journal of Transplantation

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Coronary heart disease is the leading cause of death in both diabetes mellitus and end-stage renal disease. Although renal transplantation is known to reduce mortality in end-stage renal disease, its effect on the incidence of acute coronary syndromes is unknown. Using data from the United States Renal Data System, we studied 11 369 patients with endstage renal disease due to diabetes enrolled on the renal and renal-pancreas transplant waiting list from 1 July 1994 to 30 June 1997. Cox nonproportional hazards regression models were used to calculate the adjusted, time-dependent relative risk for the most recent hospitalization for acute coronary syndromes (including acute myocardial infarction, unstable angina, or other acute coronary syndromes, ICD9 Code 410.x or 411.x) for a given patient in the study period. Demographics and comorbidities were controlled by using data from the medical evidence form (HCFA 2728). After renal transplantation, patients had an incidence of acute coronary syndromes of 0.79% per patient year, compared to 1.67% per patient year prior to transplantation. In comparison to maintenance dialysis, renal transplantation was independently associated with a lower risk for acute coronary syndromes (hazard ratio 0.38, 95% confidence interval, 0.30-0.49). Patients with end-stage renal disease due to diabetes on the renal transplant waiting list were much less likely to be hospitalized for acute coronary syndromes after renal transplantation. The reasons for this decreased risk should be the subject of further study. 274

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Beneficial Effects of Renal Transplantation on Cardiovascular Disorders in Dialysis Patients

Cited by 9 publications

References 35 publications

The Effect of Kidney Transplant on Cardiac Function: An Echocardiographic Perspective

The Effect of Kidney Transplant on Cardiac Function: An Echocardiographic Perspective

Cardiovascular Risk Assessment in Diabetes and Chronic Kidney Diseases: A New Insight and Emerging Strategies

Acute Coronary Syndromes after Renal Transplantation in Patients with End-Stage Renal Disease Resulting from Diabetes

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