Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Wiciński, Michał; Socha, Maciej W.; Walczak, Maciej; Wódkiewicz, Eryk; Malinowski, Bartosz; Rewerski, Sebastian; Górski, Karol; Pawlak-Osińska, Katarzyna

doi:10.3390/nu10111813

Cited by 71 publications

(49 citation statements)

References 114 publications

(127 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies reveal that the benefic effects of RSV are due to its potential to activate several important anti-inflammatory targets [119], although the exact mechanisms of action have not been clearly elucidated [120]. It was shown that the main target of RSV is SIRT-1, and its binding determines modifications of the SIRT-1 structure that enhances the binding of SIRT-1 to its substrates [121].…”

Section: Stilbenesmentioning

confidence: 99%

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

View full text Add to dashboard Cite

Atherosclerosis is the main process behind cardiovascular diseases (CVD), maladies which continue to be responsible for up to 70% of death worldwide. Despite the ongoing development of new and potent drugs, their incomplete efficacy, partial intolerance and numerous side effects make the search for new alternatives worthwhile. The focus of the scientific world turned to the potential of natural active compounds to prevent and treat CVD. Essential for effective prevention or treatment based on phytochemicals is to know their mechanisms of action according to their bioavailability and dosage. The present review is focused on the latest data about phenolic compounds and aims to collect and correlate the reliable existing knowledge concerning their molecular mechanisms of action to counteract important risk factors that contribute to the initiation and development of atherosclerosis: dyslipidemia, and oxidative and inflammatory-stress. The selection of phenolic compounds was made to prove their multiple benefic effects and endorse them as CVD remedies, complementary to allopathic drugs. The review also highlights some aspects that still need clear scientific explanations and draws up some new molecular approaches to validate phenolic compounds for CVD complementary therapy in the near future.In the last decade the scientific researchers turned their attention to phytochemicals, as effective, safe and low-cost natural bioactive compounds for CVD treatment.Dyslipidemia consists of increased blood concentrations of total cholesterol (TC), low density lipoproteins-cholesterol (LDL-C) and/or triglycerides (TG), and decreased high density lipoproteins-cholesterol (HDL-C) [6]. The lipid metabolism is complex and the candidate mechanisms that could generate dyslipidemia include: (i) excessive dietary lipid absorption in the small intestine; (ii) packing of exogenous lipids with cholesterol and fatty acids produced de novo in the liver and their secretion as very low density lipoproteins (VLDL); (iii) hydrolysis of TG from VLDL by lipases and their conversion into LDL, which are taken up by the peripheral tissues through LDL receptor (LDL-R) and scavenger receptors; (iv) diminished production of HDL by the liver and small intestine, thereby decreasing reverse cholesterol transport (RCT) from the peripheral tissues to the liver; (v) lowered excess cholesterol excretion from the liver into gallbladder or to the intestinal lumen through the ATP-binding cassette G5 and G8 transporters (ABCG5/G8) that facilitate trans-intestinal cholesterol efflux (TICE). Dyslipidemia is associated with the accumulation of LDL in the sub-endothelium of the artery wall. At this site, LDL undergoes oxidative modifications (oxLDL) that trigger inflammatory responses, and is taken up by the monocyte-derived macrophages infiltrated in the sub-endothelium which thus become lipid-loaded foam cells, the hallmark of atheroma development [7]. Until now, the most effective lipid-lowering treatment for hyperlipidemic patients was the statin therapy. But recen...

show abstract

Section: Stilbenesmentioning

confidence: 99%

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recent studies have reported that the blocking of BACE1 activity may prevent the progression of cerebral amyloid angiopathy associated with abnormalities in small brain vessels caused by Aβ aggregation [15]. Resveratrol (3,5,4 -trihydroxy-trans-stilbene), a polyphenol contained in red wine, peanuts, and some berries, is known for its anti-atherosclerotic, anti-inflammatory, antioxidant, and longevity-promoting properties [16]. There is ample evidence of its neuroprotective effects (Table 1).…”

Section: Aβ Peptides and Tau Proteinmentioning

confidence: 99%

“…Resveratrol has been shown to be particularly useful for the treatment of disorders such as Alzheimer's disease [16] because it prevents hippocampal neurodegeneration [29] and cognitive deficits [17]. Choi et al investigated the effect of resveratrol and its oligomers isolated from Paeonia lactiflora seed on beta-site APP-cleaving enzyme 1 (BACE-1) activity in vitro.…”

Section: Subject Of the Study Dose Effect Referencementioning

confidence: 99%

Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease

Wiciński

Domanowska

Wódkiewicz

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

The lack of effective Alzheimer's disease treatment is becoming a challenge for researchers and prompts numerous attempts to search for and develop better therapeutic solutions. Compounds that affect several routes of the neurodegeneration cascade leading to the development of disease are of particular interest. An example of such substances is resveratrol and its synthetic and natural derivatives, which have gained popularity in recent years and show promise as a possible new therapeutic option in the approach to Alzheimer's disease treatment. In this article, the state of the art evidence on the role of resveratrol (RSV) in neuroprotection is presented; research results are summarized and the importance of resveratrol and its derivatives in the treatment of Alzheimer's disease are underlined. It also focuses on various modifications of the resveratrol molecule that should be taken into account in the design of future research on drugs against Alzheimer's disease.

show abstract

“…RES exerts anti-inflammatory and immunomodulating functions through activation of sirtuin-1 (Sirt-1) [87]. Sirt-1 operates by disrupting the TLR-4/NF-B/signal transducer and activator of transcription (STAT) pathway with decreased production of cytokines, platelet activating factor and histamine [88,89]. Sirt-1, as a deacetylase, plays an important role in immune tolerance and its abrogation leads to a spontaneous development of autoimmune disease [90,91].…”

Section: Regulation Of Immune Functions By Polyphenolsmentioning

confidence: 99%

“…RES -Activation of Sirt-1 with disruption of the TLR-4/NF-B/STAT pathway and decreased production of cytokines, PAF and histamine [87][88][89]; -Induction of AMP-activated protein kinase with increased levels of NAD+ which, in turn,…”

Section: Polyphenol Activitymentioning

confidence: 99%

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

Magrone¹,

Magrone²,

Russo³

et al. 2019

Preprint

View full text Add to dashboard Cite

In this review, special emphasis will be placed on red grape polyphenols for their anti-oxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of pro-inflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Furthermore, the effects of red grape polyphenols will be analyzed in obesity, as a low grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood-brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great anti-oxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites and interaction with microbiota, deserve deeper studies.

show abstract

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Cited by 71 publications

References 114 publications

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

Contact Info

Product

Resources

About