2021
DOI: 10.1007/s10787-021-00874-z
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Beneficial effects of secretome derived from mesenchymal stem cells with stigmasterol to negate IL-1β-induced inflammation in-vitro using rat chondrocytes—OA management

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Cited by 13 publications
(16 citation statements)
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“…Similarly, Sampath et al [ 46 ] attempted in their investigation to test in vitro the possible beneficial effects of stigmasterol with the MSC-condition medium (MSC-CM). The results showed a significant decrease in MMP-3, MMP-13, and ADAMTS-5, as well as a significant increase in the expression of collagen type II, alpha 1 (COL2A1) was found to mimic OA in vitro in primary rat articular chondrocytes, as evidenced by immunofluorescence and qRT-PCR.…”
Section: Anti-osteoarthritis Effectsmentioning
confidence: 99%
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“…Similarly, Sampath et al [ 46 ] attempted in their investigation to test in vitro the possible beneficial effects of stigmasterol with the MSC-condition medium (MSC-CM). The results showed a significant decrease in MMP-3, MMP-13, and ADAMTS-5, as well as a significant increase in the expression of collagen type II, alpha 1 (COL2A1) was found to mimic OA in vitro in primary rat articular chondrocytes, as evidenced by immunofluorescence and qRT-PCR.…”
Section: Anti-osteoarthritis Effectsmentioning
confidence: 99%
“…The results showed a significant decrease in MMP-3, MMP-13, and ADAMTS-5, as well as a significant increase in the expression of collagen type II, alpha 1 (COL2A1) was found to mimic OA in vitro in primary rat articular chondrocytes, as evidenced by immunofluorescence and qRT-PCR. In fact, the combined therapy (MSC cm and stigmasterol) elicited a greater anticatabolic effect by suppressing IL-1β-induced NF-κB activation, as indicated by insignificant phosphorylation of p65 and IκBα subunits [ 46 ].…”
Section: Anti-osteoarthritis Effectsmentioning
confidence: 99%
See 2 more Smart Citations
“…In recent years, the efficacy of MSC-derived EVs in OA has attracted great attention [5]. Also, secretomes originated from MSCs have emerged as anti-inflammatory mediators in rat chondrocytes [31]. More importantly, MSC-derived EVs exert potential to accelerate cartilage regeneration and osteogenesis through paracrine mechanisms due to their ability to transfer molecules such 11 Stem Cells International as mRNAs and miRNAs [32,33].…”
Section: Discussionmentioning
confidence: 99%