Beneficial Effects of Swertiamarin on Dyslipidaemia in Streptozotocin‐induced Type 2 Diabetic Rats

Abstract

Dyslipidaemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. Lipid changes associated with diabetes mellitus are attributed to increases in free fatty acid flux, secondary to insulin resistance. In the present study, we have investigated the beneficial effects of swertiamarin on dyslipidaemic conditions associated with type 2 diabetes in streptozotocin-induced type 2 diabetic rats. Swertiamarin (50 mg/kg, i.p.) administered once a day for 6 weeks resulted in significant (p < 0.001) reductions in serum triglycerides, cholesterol and low-density lipoprotein levels in diabetic animals as compared with diabetic control animals. Serum fasting glucose was significantly (p < 0.05) decreased, moreover, the insulin sensitivity index was significantly (p < 0.05) increased in swertiamarin treated animals. Overall the data suggest that swertiamarin has beneficial effects on diabetic associated complications such as dyslipidaemia.

Swertiamarin: An Active Lead fromEnicostemma littoraleRegulates Hepatic and Adipose Tissue Gene Expression by Targeting PPAR-γand Improves Insulin Sensitivity in Experimental NIDDM Rat Model

“…SM is beneficial in bringing the lipid profile in neonatal-STZ rats to normal. [18]. HMG-CoA reductase is a key enzyme involved in the cholesterol biosynthesis in the hepatic tissue, which increases the free fatty acid level that leads to insulin resistance.…”

“…Also, other groups have focused on physiological and biochemical studies in neonatal-STZ models to understand role of SM for the treatment of obesity and dyslipidemia. However, the mechanism of action of SM has not been explored at a systemic level [17, 18]. …”

Clinical Study to Assess the Efficacy and Safety of a Citrus Polyphenolic Extract of Red Orange, Grapefruit, and Orange (Sinetrol‐XPur) on Weight Management and Metabolic Parameters in Healthy Overweight Individuals

“…), and flavonols (quercetin and kaempferol). Flavonoids have taken an increasing importance with regard to their health benefits in prevention and treatment of cancer (Chen et al ., ; Moghaddam et al ., ; Mansoor et al ., ; Seito et al ., ; Yang et al ., in press), inflammatory diseases (Laughton et al ., ; Kim et al ., ; Dai et al ., ), CV diseases (Frankel et al ., ; Moon et al ., ; Vaidya et al ., ), and neurodegenerative diseases (Orgogozo et al ., ; Kou et al ., ; Zhang et al ., ). Dietary phytochemicals, such as polyphenols, may prevent the risk of obesity‐associated chronic diseases such as type 2 diabetes (Dembinska‐Kiec et al ., ; Décordé et al ., ).…”

Evaluation and quantitative analysis of different growth periods of herb–arbor intercropping systems using HPLC and UV–vis methods coupled with chemometrics

“…In one sense, the content of gentiopicroside represents the quality of GR. Nevertheless, the other five main active constituents, i.e., loganic acid, swertiamarin, sweroside, isoorientin, and isovitexin, also perform various roles such as antioxidant, antiedematogenic, antinociceptive, antihyperlipidaemia, anti-inflammatory, and antifungal activities [22][23][24][25][26][27][28][29][30]. The samples biennially cultivated in intercropping systems with Camellia sinensis not only contained more gentiopicroside than others but also loganic acid, sweroside, and total content.…”