2001
DOI: 10.1002/jat.812
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Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage and learning behaviour

Abstract: Poisoning with the potent nerve agent soman produces a cascade of central nervous system (CNS) effects characterized by severe convulsions and eventually death. In animals that survive a soman intoxication, lesions in the amygdala, piriform cortex, hippocampus and thalamus can be observed. In order to examine the mechanisms involved in the effects of soman and to evaluate possible curative interventions, a series of behavioural, electrophysiological and neuropathological experiments were carried out in the gui… Show more

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Cited by 35 publications
(24 citation statements)
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“…Pilocarpine-treated animals exhibited a decrease in physical activity 30-h post-exposure. Although there are few reports describing the physical activity of CWNA-exposed animals (de Groot et al, 2001), our behavioral analysis showed significant differences. Pilocarpine did not significantly affect the heart rate or ECG in the present experiment.…”
Section: Salinementioning
confidence: 71%
“…Pilocarpine-treated animals exhibited a decrease in physical activity 30-h post-exposure. Although there are few reports describing the physical activity of CWNA-exposed animals (de Groot et al, 2001), our behavioral analysis showed significant differences. Pilocarpine did not significantly affect the heart rate or ECG in the present experiment.…”
Section: Salinementioning
confidence: 71%
“…The early transcriptional response at 2 h following [30], and the corresponding induction of signal transduction processes [31]. This is followed by the activation of glutamate receptors leading to the release of the excitatory L-glutamate amino acid neurotransmitter [32]. This in turn activates N-methyl-Daspartate (NMDA) subtype of glutamate receptor and the opening of NMDA Calcium channels, resulting in massive Ca 2+ influx of post synaptic cell causing neuronal degeneration [33,34].…”
Section: Discussionmentioning
confidence: 99%
“…Soman (methylphosphonofluoridic acid 1,2,2-trimethylpropyl ester) is a potent acetylcholinesterase inhibitor [1]. The neuropathological sequelae of severe soman toxicity include neural lesions of the amygdala, hippocampus, piriform cortex and thalamus [6]. However, the effects of organophosphate poisoning on the immune system have been less well characterized.…”
Section: Discussionmentioning
confidence: 99%