Beneficial effects of telmisartan on left ventricular structure and function in patients with hypertension determined by two-dimensional strain imaging

Abstract

The use of telmisartan in patients with hypertension improved not only LV geometric remodeling but also regional LV myocardial contraction and relaxation in the three directions, especially longitudinal and circumferential directions. Our results support beneficial effects on LV structure and function beyond BP reduction from continuous long-term telmisartan therapy.

The differences in left ventricular torsional behavior between patients with hypertrophic cardiomyopathy and hypertensive heart disease

“…Therefore, modalities such as MRI and 3D echocardiography may provide more accurate information about LV geometry [35]. Lastly, a recent study has shown the beneficial effect of angiotensin receptor blocker on LV systolic and diastolic properties using a speckle tracking method [36]. An antihypertensive drug effect on LV torsional behavior in the present study could not be completely omitted despite discontinuance of all drugs before echo measurements.…”

Myocardial Strain Characterization in Different Left Ventricular Adaptative Responses to High Blood Pressure: A Study Based on 3D‐Wall Motion Tracking Analysis

“…Also, an impaired longitudinal negative strain has been correlated with serum markers 23 which suggest that the myocardial fibrotic process may affect the early contractile dysfunction of LV. The pharmacological treatment of hypertensive patients improves LV geometric remodelling and also regional LV myocardial contraction and relaxation in the three spatial directions, especially longitudinal and circumferential directions 24 . It is also of note that in a recent paper by Mu et al 25 speckle tracking imaging has demonstrated its usefulness in evaluating early changes in left ventricular diastolic function in hypertensive patients.…”

Effect of an Increase in Left Ventricular Pressure Overload on Left Atrial‐Left Ventricular Coupling in Patients with Hypertension: A Two‐Dimensional Speckle Tracking Echocardiographic Study

“…Previous studies using electrocardiogram and conventional echocardiographic indices demonstrated that (1) pressure-related LV diastolic dys-function is the dominant feature in spontaneous hypertensive rats, 16 (2) LA enlargement provides the initial evidence of LV dysfunction, and later, when LV hypertrophy becomes clinically apparent, further impairment of LV function is evident in hypertension, 17 and (3) hypertensive heart disease develops from no LA and LV structural changes (stage I) to LA enlargement with no LV hypertrophy (stage II) and to definite LV hypertrophy (stage III). [21][22][23] Recently, the development of 2DSTE, in which angle-independent strain measurement is possible, has facilitated the rapid and detailed evaluation of regional LA and LV myocardial shortening or lengthening in the longitudinal and circumferential directions, and thickening or thinning in the radial direction. 3 In particular, systolic PVF velocity reflects LA pressure or compliance, 19 and therefore is usually used as a parameter of LA filling.…”