Beneficial effects of the combination of idebenone and manidipine 2HCl on neurological deficits and histological changes following cerebrovascular lesions in stroke-prone spontaneously hypertensive rats.

Nagisa, Yasutaka; Mihara, Tomoko; Hamajo, Kazuhiro; Imamoto, Tetsuji; Kandori, Hitoshi; Oda, Emiko; Chatani, Fumio; Nagaoka, Akinobu

doi:10.1254/fpj.106.327

Cited by 1 publication

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“…Nicardipine has anti-neuroinflammatory effects on microglial cells and exerts a protective effect against rotenone-induced apoptosis [27]. The combination of manidipine and idebenone significantly ameliorates neurological deficits and histological changes in the rat brain following stroke [28]. In addition, benidipine has been shown to prevent inflammatory changes and oxidative stress in a rat model of myocardial infarction [29].…”

Section: Network Construction Similarity Analysis and Verification Of...mentioning

confidence: 99%

Computational Drug Repositioning for Ischemic Stroke: Neuroprotective Drug Discovery

Yang

Zhang

et al. 2021

Future Med. Chem.

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Background: A comprehensive approach to drug repositioning will be required to overcome translational hurdles and identify more neuroprotective drugs. Results & methods: Gene Set Enrichment Analysis was applied to identify related pathways and enriched genes. Candidate genes were optimized using ToppGene, ToppGenet and pBRIT. From the perspective of the local structures, gene–domain–substructure–drug relationships were constructed. Using the MCODE algorithm and K-means clustering, 31 functional subnetworks were obtained, and 252 drugs with proposed neuroprotective function were identified. Using computational analysis, 72 substructures with different scores were found to correspond to neuroprotective functions. The protective effects of benidipine and barnidipine were confirmed in vitro. Conclusion: The authors' research has great potential to discover more neuroprotective drugs and obtain more information regarding mechanisms of action and functional substructures.

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Section: Network Construction Similarity Analysis and Verification Of...mentioning

confidence: 99%

Computational Drug Repositioning for Ischemic Stroke: Neuroprotective Drug Discovery

Yang

Zhang

et al. 2021

Future Med. Chem.

View full text Add to dashboard Cite

show abstract

Beneficial effects of the combination of idebenone and manidipine 2HCl on neurological deficits and histological changes following cerebrovascular lesions in stroke-prone spontaneously hypertensive rats.

Cited by 1 publication

References 11 publications

Computational Drug Repositioning for Ischemic Stroke: Neuroprotective Drug Discovery

Computational Drug Repositioning for Ischemic Stroke: Neuroprotective Drug Discovery

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