Beneficial health effects of Menaquinone‐7 on body composition, glycemic indices, lipid profile, and endocrine markers in polycystic ovary syndrome patients

Tarkesh, Firoozeh; Jahromi, Bahia Namavar; Hejazi, Najmeh; Tabatabaee, Hamidreza

doi:10.1002/fsn3.1837

Cited by 21 publications

(17 citation statements)

References 46 publications

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“…Furthermore, MK-7 intake led to significantly lower serum triglyceride level (p = 0.003), waist circumference (p = 0.03), and body fat mass (p < 0.001). In this study, MK-7 intake showed beneficial effects on glycemic indices but also on lipid and anthropometric profiles in PCOS patients [150].…”

Section: The Effects Of Vitamin K On Metabolic Disordersmentioning

confidence: 51%

The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases

2021

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As human life expectancy is rising, the incidence of age-associated diseases will also increase. Scientific evidence has revealed that healthy diets, including good fats, vitamins, minerals, or polyphenolics, could have antioxidant and anti-inflammatory activities, with antiaging effects. Recent studies demonstrated that vitamin K is a vital cofactor in activating several proteins, which act against age-related syndromes. Thus, vitamin K can carboxylate osteocalcin (a protein capable of transporting and fixing calcium in bone), activate matrix Gla protein (an inhibitor of vascular calcification and cardiovascular events) and carboxylate Gas6 protein (involved in brain physiology and a cognitive decline and neurodegenerative disease inhibitor). By improving insulin sensitivity, vitamin K lowers diabetes risk. It also exerts antiproliferative, proapoptotic, autophagic effects and has been associated with a reduced risk of cancer. Recent research shows that protein S, another vitamin K-dependent protein, can prevent the cytokine storm observed in COVID-19 cases. The reduced activation of protein S due to the pneumonia-induced vitamin K depletion was correlated with higher thrombogenicity and possibly fatal outcomes in COVID-19 patients. Our review aimed to present the latest scientific evidence about vitamin K and its role in preventing age-associated diseases and/or improving the effectiveness of medical treatments in mature adults ˃50 years old.

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Section: The Effects Of Vitamin K On Metabolic Disordersmentioning

confidence: 51%

The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases

2021

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“…Plus, osteocalcin, a vitamin K-dependent protein, induces insulin secretion by affecting pancreatic β-cells [ 36 – 38 ]. Having said all that, in our previous study [ 24 ], fasting blood sugar was not significantly affected by 8 weeks of MK-7 consumption compared to administrating placebo capsules in PCOS patients. In line with the mentioned study, Shahdadian et al [ 39 ] in a systematic review and meta-analysis reported that vitamin K administration could not significantly affect glycemic control within healthy individuals.…”

Section: Discussionmentioning

confidence: 86%

“…Also, Knapen et al did not observe any significant alteration in fasting blood sugar after three years of MK-7 supplementation in postmenopausal women [ 41 ]. In our previous study [ 24 ], all the participants had normal serum vitamin K level at baseline; it can be hypothesized that vitamin K administration may have greater effects on fasting blood sugar in vitamin K deficient individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Three-day dietary records were completed by participants before and after this trial. We computed the patients’ daily energy and intakes of macronutrients (carbohydrate, fat and protein) and micronutrients (vitamin K and vitamin D) by means of Nutritionist 4 software (first data bank, San Bruno, CA, USA) that was adjusted for Persian foods [ 24 ]. In addition, the level of physical activity was evaluated through completing the validated version of International Physical Activity Questionnaire (IPAQ) at baseline of the trial [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

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Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial

et al. 2022

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Background Patients with Polycystic ovary syndrome (PCOS) are predisposed to the development of several mental comorbidities such as depression. According to several studies, PCOS can be managed by improving insulin sensitivity. The insulin-sensitizing effect of vitamin K has been reported in recent studies. Therefore, in the current trial, we assessed the effect of administrating vitamin K2 (Menaquinone-7) on depression status in women afflicted with PCOS. Methods Eighty-four PCOS women were allocated into the intervention and comparison groups; the intervention group (n = 42) administered 90 µg/day Menaquinone-7, and the comparison group (n = 42) consumed placebo capsules (containing avesil) for 8 weeks. In this randomized, double blind, placebo-controlled clinical trial, depression status was measured by BECK depression inventory-II (BDI-II) before and after 8 weeks of intervention. Results Consumption of Menaquinone-7 in comparison with the placebo capsules significantly improved depression status (P = 0.012). Conclusion This clinical study reported the advantageous effect of Menaquinone-7 administration on depression status in PCOS patients. Trial registration The present study was registered at http://www.IRCT.ir on 06/06/2018 (registration number: IRCT20170916036204N5).

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“…MK-7 plays a role in respiratory chain transmission, coagulation function, and calcium homeostasis ( Turck et al, 2017 ; Wilkens et al, 2021 ; Wu et al, 2021 ). In addition, MK-7 has more and more benefits in promoting bone healing, preventing cerebrovascular and cardiovascular diseases and fighting cancer cells, Alzheimer’s disease and Parkinson’s disease ( Halder et al, 2019 ; Mahdinia et al, 2019a ; Tarkesh et al, 2020 ). However, the human body cannot synthesize MK-7, and the only channels to obtain it are food and dietary supplements ( Bergeland et al, 2019 ; Brudzynski and Flick, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Alkali Stress on the Growth and Menaquinone-7 Metabolism of Bacillus subtilis natto

et al. 2022

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Menaquinone-7 (MK-7) is an important vitamin K2, synthesized from the menaquinone parent ring and seven isoprene side chains. Presently, the synthesis of MK-7 stimulated by environmental stress primarily focuses on oxygen stress, while the effect of alkali stress is rarely studied. Therefore, this study researched the effects of alkali stress on the fermentation performance and gene expression of Bacillus subtilis natto. The organism’s growth characteristics, biomass, sporogenesis, MK-7 biosynthesis, and gene expression were analyzed. After a pH 8.5 stress adaptation treatment for 0.5 h and subsequent fermentation at pH 8.5, which promoted the growth of the strain and inhibited the spore formation rate. In addition, biomass was significantly increased (P < 0.05). The conversion rate of glycerol to MK-7 was 1.68 times higher than that of the control group, and the yield of MK-7 increased to 2.10 times. Transcriptomic analysis showed that the MK-7 high-yielding strain had enhanced carbon source utilization, increased glycerol and pyruvate metabolism, enhanced the Embden-Meyerhof pathway (EMP), tricarboxylic acid (TCA) circulation flux, and terpenoid biosynthesis pathway, and promoted the accumulation of acetyl-CoA, the side-chain precursor of isoprene. At the same time, the up-regulation of transketolase increased the metabolic flux of the pentose phosphate (HMP) pathway, which was conducive to the accumulation of D-erythrose 4-phosphate, the precursor of the menadione parent ring. This study’s results contribute to a better understanding of the effects of environmental stress on MK-7 fermentation by Bacillus subtilis natto and the molecular regulatory mechanism of MK-7 biosynthesis.

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Beneficial health effects of Menaquinone‐7 on body composition, glycemic indices, lipid profile, and endocrine markers in polycystic ovary syndrome patients

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 21 publications

References 46 publications

The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases

The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases

Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial

Effects of Alkali Stress on the Growth and Menaquinone-7 Metabolism of Bacillus subtilis natto

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