2015
DOI: 10.1038/srep16920
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Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis

Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Gpnmb is classified as a type 1 membrane protein and its soluble form is secreted by ADAM10-mediated cleavage. Gpnmb mRNA was found in the Kupffer cells and white adipose tissues (WATs) and its upregulation in obesity was recently found. Here, we generated aP2 promoter-driven Gpnmb transgenic (Tg) mice and the overexpression of Gpnmb ameliorated the fat accumulation and fibrosis of the liver in diet-induced ob… Show more

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Cited by 66 publications
(72 citation statements)
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“…Of the top 10 dys-regulated mRNAs, Gpnmb had the highest fold change in the up regulated mRNAs and was previously identified as biomarker of NASH [22] while increased NLRP3 reinforced its role in NASH progression suggested by previous studies [23]. All these consistency reinforces the credibility of our results.…”
Section: Discussionsupporting
confidence: 89%
“…Of the top 10 dys-regulated mRNAs, Gpnmb had the highest fold change in the up regulated mRNAs and was previously identified as biomarker of NASH [22] while increased NLRP3 reinforced its role in NASH progression suggested by previous studies [23]. All these consistency reinforces the credibility of our results.…”
Section: Discussionsupporting
confidence: 89%
“…Other TCDD-elicited proinflammatory and immunogenic activities include the hepatic induction of Il1a, Ccl2, Ccl3, and Ccl4 mRNA levels 1.9-, 1.7-, 1.7-, and 1.7-fold, respectively ( Figure 7C). Countering these proinflammatory signals was the 28.7-and 58.1-fold induction of glycoprotein non-metastatic melanoma B (Gpnmb), a macrophage expressed transmembrane glycoprotein that negatively regulates inflammation (Katayama et al, 2015).…”
Section: Effects Of Tcdd On Proline and Hydroxyproline Metabolismmentioning
confidence: 99%
“…Gpnmb encodes for Glycoprotein Non-Metastatic Protein B (GPNMB) which was originally discovered in a melanoma cell line[21]. This protein, also called osteoactivin, DC-HIL, or hematopoietic growth factor inducible neurokinin-1, has been studied extensively in many contexts including cancer, kidney injury, obesity, non-alcoholic steatohepatitis, Parkinson disease, osteoarthritis, lysosome storage disorders, and heart failure; and, in most of these contexts expression of GPNMB is induced by the related pathology, likely in response to lysosomal stress[12, 2227]. However, loss of Gpnmb expression in DBA/2J mice is associated with preserved cardiac function after myocardial infarction[28].…”
Section: Discussionmentioning
confidence: 99%