Beneficial microbiota. Probiotics and pharmaceutical products in functional nutrition and medicine

Новик, Г. И.; Savich, Victoria

doi:10.1016/j.micinf.2019.06.004

Cited by 56 publications

(38 citation statements)

References 110 publications

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“…Yang and colleagues reported that soybeans fermented with Bacillus licheniformis enhanced cognitive function in diabetic rats with AD-type dementia [154]. Several proteinases produced by Bacillus pumilus and Bacillus subtilis and present in fermented soy products possess amyloid-degrading activity; therefore, they can be developed into anti-aggregation drugs [155,156], although many hurdles in the delivery of the proteases to target sites are anticipated. Another study found that Bacillus subtilis, a microorganism that is predominant in traditionally made cheonggukjang, restored the lifespan of Caenorhabditis elegans strains that expressing Aβ to values similar to the life expectancy of the wild-type strain [157].…”

Section: Gut Microbiota and Admentioning

confidence: 99%

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang

Lim

et al. 2021

Foods

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Fermented soybean products, such as cheonggukjang (Japanese natto), doenjang (soy paste), ganjang (soy sauce), and douchi, are widely consumed in East Asian countries and are major sources of bioactive compounds. The fermentation of cooked soybean with bacteria (Bacillus spp.) and fungi (Aspergillus spp. and Rhizopus spp.) produces a variety of novel compounds, most of which possess health benefits. This review is focused on the preventive and ameliorative potential of fermented soy foods and their components to manage neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases.

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Section: Gut Microbiota and Admentioning

confidence: 99%

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang

Lim

et al. 2021

Foods

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“…Probiotics are defined as "live microorganisms which, when administered in adequate amounts confers a health benefit on the host" [140]. The most commonly used are those belonging to the Lactobacillus and Bifidobacterium genera, which are commensal bacteria that live in or on human bodies [141]. They can regulate the balance of gut microbes, promote the growth and development of animals, and also improve the host's resistance to diseases [142] and thus improve the host's health.…”

Section: Probiotics: a New Approach To Modulate The Reproductive Tracmentioning

confidence: 99%

Microflora in the Reproductive Tract of Cattle: A Review

Appiah

Wang

2020

Agriculture

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There are microbial communities in and on the bodies of all multicellular organisms, and this microbiota can have a significant impact on the biology of the host. Most studies have focused on the microbiome of the skin, mouth, and gut, whereas relatively little is known about the reproductive microbiome. From the perspective of the bovine reproductive tract, uterine diseases such as metritis and endometritis are traditionally viewed to result only from interactions occurring between the host animal and pathogens originating from either the environment or ascension from the vagina. This outdated opinion has been refuted by recent advanced studies that propose that, in addition to bacteria colonization through the extrinsic and ascending pathways to the vagina, bacteria can also move from the gut to the uterus, which is also associated with reproductive tract disorders. This has led to the concept of the “endogenous route hypothesis”, which has vital inferences for comprehending the etiology of metritis and endometritis. Furthermore, it has opened up the possibility of developing new prophylactic and therapeutic agents as alternatives to antimicrobial agents. In addition, the unveiling of next-generation sequencing technology makes it more convenient to perform detailed sequencing and analysis of data on the cervical, vaginal, and uterine flora and to further study uncultured bacteria in these niches—most importantly, the cervical niche, which previously was thought to have lower bacterial complexity. Research conducted to date has proven that the composition of microflora in a community varies widely between environmental sites, host niches, and health status. Furthermore, it has also been suggested that the occurrence of endometritis in the dairy and beef cattle reproductive tract is neither casual nor indirect but multifactorial. Whether disturbance in the variety of the microflora in the reproductive tract (dysbiosis) has a role in determining the sensitivity to metritis and endometritis is not yet known. This article outlines the current progress in understanding the microflora with regards to the bovine reproductive tract. The compositions of microflora in various niches of the reproductive tract are briefly elucidated. In addition, the functional role of these microflora communities in the reproductive tract is discussed, with particular emphasis on the association of bacterial flora with reproductive disorders and failures. Finally, prophylaxis and therapeutic approaches based on the new comprehension of the effects of antimicrobials, probiotics, and bacteriophages on the composition of the reproductive tract microflora are also considered.

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“…These targets sites are including protease, (Joshi et al, 2020) different enzymes (Gupta et al, 2020;Khan et al, 2020), protein terminals, (Sarma et al, 2020) proteins including various polymerase (Elfiky & Azzam, 2020) and small peptides (Pant et al, 2020) can be a good option. Probiotics are living organism with health-promoting benefits when consumed adequate amount either in the form of diet or drugs (Novik & Savich, 2020), is beneficial for health. Lactobacillus bacterial species plays a vital role in the treatment of gastrointestinal disorder and are known to possess antibacterial (Di Cerbo et al, 2016) and anti-viral (Sunmola et al, 2019) properties.…”

Section: Introductionmentioning

confidence: 99%

Antiviral effects of probiotic metabolites on COVID-19

Anwar

Altayb

Al-Abbasi

et al. 2020

Journal of Biomolecular Structure and Dynamics

104

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SARS coronavirus (COVID-19) is a real health challenge of the 21st century for scientists, health workers, politicians, and all humans that has severe cause epidemic worldwide. The virus exerts its pathogenic activity through by mechanism and gains the entry via spike proteins (S) and Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins on host cells. The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp). Docking studies were designed in order to obtain the binding energies for Plantaricin metabolites. The binding energies for Plantaricin W were À14.64, À11.1 and À12.68 for polymerase, RBD and ACE2 respectively comparatively very high with other compounds. Plantaricin W, D, and JLA-9 were able to block the residues (THR556, ALA558) surrounding the deep grove catalytic site (VAL557) of RdRp making them more therapeutically active for COVID-19. Molecular dynamics studies further strengthen stability of the complexes of plantaricin w and SARS-CoV-2 RdRp enzyme, RBD of spike protein, and human ACE2 receptor. The present study present multi-way options either by blocking RBD on S proteins or interaction of S protein with ACE2 receptor proteins or inhibiting RdRp to counter any effect of COVID-19 by Plantaricin molecules paving a way that can be useful in the treatment of COVID-19 until some better option will be available.

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Beneficial microbiota. Probiotics and pharmaceutical products in functional nutrition and medicine

Cited by 56 publications

References 110 publications

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Microflora in the Reproductive Tract of Cattle: A Review

Antiviral effects of probiotic metabolites on COVID-19

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