Beneficial properties and mechanisms of natural phytochemicals to combat and prevent hyperuricemia and gout

Wu, Jimin; Alhamoud, Yasmin; Lv, Shihui; Feng, Fengqin; Jing, Wang

doi:10.1016/j.tifs.2023.06.021

Cited by 17 publications

(3 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Xa is generated through the action of xanthine oxidase and gets further oxidised to form UA. UA is associated with diseases such as hyperuricemia and gout (Wu et al, 2023). Therefore, the contents of Hx, Xa and UA are key indicators reflecting the quality of shrimp.…”

Section: Organic Heterocyclic Compoundsmentioning

confidence: 99%

Metabolism effects of static magnetic field‐assisted freezing on shrimp (Penaeus vannamei)

Zhu,

Fu,

Yang

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

SummaryShrimp undergo rapid deterioration after death, primarily due to enzyme activity and microbial growth, with freezing serving as its primary preservation method. In this study, shrimp underwent both conventional freezing (CF) and magnetic field‐assisted freezing (MF), and the shrimp meat's metabolites were scrutinised via metabonomic analysis techniques. The results demonstrate that MF treatment effectively preserved umami components like glutamic acid (log2(FC) = 0.37) and inosinic acid (1.02) while inhibiting the accumulation of spoilage‐related metabolites such as inosine (HxR) (−2.51), hypoxanthine (Hx) (−1.43) and uric acid (UA) (−1.24). Moreover, specific compounds, including 3‐methylhistidine, 1,6‐bisphosphate, phosphatidylcholine (PC), phosphatidylethanolamine (PE), HxR, Hx and UA were recognised as potential biomarkers throughout the freezing process. This research offers crucial insights into the intricate molecular mechanisms behind magnetic field‐assisted freezing.

show abstract

Section: Organic Heterocyclic Compoundsmentioning

confidence: 99%

Metabolism effects of static magnetic field‐assisted freezing on shrimp (Penaeus vannamei)

Zhu,

Fu,

Yang

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…Natural products containing flavonoids, terpenoids, alkaloids, and other compounds show promise as URAT1 or XO inhibitors [42,43]. Phytochemicals derived from natural sources possess the beneficial property of downregulating UA levels and dissolving monosodium urate crystals [44]. Specific TCM components like Dendrobium officinale exhibit anti-HU effects by regulating urate transport-related transporters and inhibiting XO activity [45].…”

Section: Treatment Strategiesmentioning

confidence: 99%

Hyperuricemia: Current State and Prospects

Zhang

2024

Preprint

View full text Add to dashboard Cite

Hyperuricemia (HU), characterized by elevated uric acid (UA) levels in the blood, represents a global health concern associated with various conditions, including cardiovascular diseases, gout, hypertension, metabolic syndrome, renal dysfunction, and neurodegenerative diseases. This review offers a contemporary analysis of HU, encompassing its causes, associated health risks, diagnosis, treatment, and future outlook. Recent studies have underscored the multifaceted origin of HU, implicating genetic predisposition, dietary patterns, lifestyle choices, and environmental influences. Genetic variations affecting enzymes and transporters involved in purine metabolism and UA excretion have been identified, laying the groundwork for personalized treatment strategies. Advances in diagnostic imaging and omics technologies provide enhanced precision in the detection and evaluation of risks. While pharmacological interventions remain central to managing HU, persistent challenges such as treatment resistance prompt exploration of novel drug targets and lifestyle modifications. Chinese herbal medicines offer a potentially alternative approach with fewer side effects. Emerging research on the impact of gut microbiota on UA metabolism opens new therapeutic avenues. Despite progress, challenges such as optimizing treatment duration and understanding long-term effects persist. Collaborative efforts are crucial to address these challenges and advance our comprehension of HU. The integration of precision medicine and holistic patient care approaches holds promise for improving outcomes and enhancing quality of life for individuals with HU.

show abstract

“…In the ever-evolving landscape of gout and hyperuricemia management, the search for new and better-tolerated therapies has spurred a focused exploration into natural compounds, particularly sesquiterpene lactones 12 , 13 . Among these, eremantholide C (EREC) and goyazensolide (GOIA), whose structures are shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of liposomal formulations containing sesquiterpene lactones for the treatment of chronic gout

Cunha Matosinhos,

Frézard,

Mendes Silva Araújo

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Gout and hyperuricemia are characterized by high uric acid levels, and their treatment involves medications that have adverse effects. In this study, we evaluated oral liposomal formulations with eremantholide C and goyazensolide as a novel approach to reduce the toxicity associated with these substances while maintaining their anti-hyperuricemic activity. We characterized the formulations and evaluated them based on encapsulation efficiency and stability over 12 months and under simulated physiological environments. We determined the toxicity of the liposomal formulations in Caco-2 cells and the anti-hyperuricemic activity in rats. The formulations exhibited nanometric size, a narrow size distribution, and a negative zeta potential, indicating their stability and uniformity. The efficient encapsulation of the sesquiterpene lactones within the liposomes emphasizes their potential for sustained release and therapeutic efficacy. Stability evaluation revealed a small decrease in the eremantholide C concentration and a remarkable stability in the goyazensolide concentration. In Caco-2 cells, the liposomes did not exert toxicity, but did exhibit an antiproliferative effect. In vivo assays demonstrated that the liposomes reduced serum uric acid levels. Our study represents an advancement in gout and hyperuricemia treatment. The liposomal formulations effectively reduced the toxicity associated with the sesquiterpene lactones while maintaining their therapeutic effects.

show abstract

Beneficial properties and mechanisms of natural phytochemicals to combat and prevent hyperuricemia and gout

Cited by 17 publications

References 92 publications

Metabolism effects of static magnetic field‐assisted freezing on shrimp (Penaeus vannamei)

Metabolism effects of static magnetic field‐assisted freezing on shrimp (Penaeus vannamei)

Hyperuricemia: Current State and Prospects

Development and characterization of liposomal formulations containing sesquiterpene lactones for the treatment of chronic gout

Contact Info

Product

Resources

About