Beneficial Properties of Bromelain

Hikisz, Paweł; Bernasińska-Słomczewska, Joanna

doi:10.3390/nu13124313

Cited by 59 publications

(68 citation statements)

References 221 publications

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“…The development and clinical introduction of novel pharmacological compounds are often hindered by problems, such as low selectivity for target cells or high toxicity against normal cells. Therefore, phytochemicals are continuously explored as possible therapeutics because they generally exert few unwanted harmful side effects and are well-tolerated by patients [ 23 ]. Moreover, they bear the advantages of having a high availability and relative simplicity of acquisition [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Bromelain Protects Critically Perfused Musculocutaneous Flap Tissue from Necrosis

et al. 2022

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Bromelain has previously been shown to prevent ischemia-induced necrosis in different types of tissues. In the present study, we, therefore, evaluated for the first time, the tissue-protective effects of bromelain in musculocutaneous flaps in mice. Adult C57BL/6N mice were randomly assigned to a bromelain treatment group and a control group. The animals were treated daily with intraperitoneal injections of 20 mg/kg bromelain or saline (control), starting 1 h before the flap elevation throughout a 10-day observation period. The random-pattern musculocutaneous flaps were raised on the backs of the animals and mounted into a dorsal skinfold chamber. Angiogenesis, nutritive blood perfusion and flap necrosis were quantitatively analyzed by means of repeated intravital fluorescence microscopy over 10 days after surgery. After the last microscopy, the flaps were harvested for additional histological and immunohistochemical analyses. Bromelain reduced necrosis of the critically perfused flap tissue by ~25%. The bromelain-treated flaps also exhibited a significantly higher functional microvessel density and an elevated formation of newly developed microvessels in the transition zone between the vital and necrotic tissues when compared to the controls. Immunohistochemical analyses demonstrated a markedly lower invasion of the myeloperoxidase-positive neutrophilic granulocytes and a significantly reduced number of cleaved caspase 3-positive apoptotic cells in the transition zone of bromelain-treated musculocutaneous flaps. These findings indicate that bromelain prevents flap necrosis by maintaining nutritive tissue perfusion and by suppressing ischemia-induced inflammation and apoptosis. Hence, bromelain may represent a promising compound to prevent ischemia-induced flap necrosis in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Bromelain Protects Critically Perfused Musculocutaneous Flap Tissue from Necrosis

et al. 2022

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“…Bromelain has anti-viral and anti-inflammatory properties that support the effect of Boswellia increasing its anti-inflammatory capacities; the anti-viral effect of Bromelain ulteriorly reduces the inflammation, even stopping the viral diffusion [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Honey, Tyndallized Lactobacillus Acidophilus and Casei to Fight Upper Respiratory Tract Infection and Otitis Media

Volpe¹,

Luca

Lucia³

et al. 2022

Healthcare

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Some nutraceuticals have been studied as supportive treatment for fighting upper respiratory tract infection and middle ear disease. Our study aims at evaluating the effect of a specific oral supplementation in the treatment of pediatric otits media. The subjects were randomly assigned by the physician (single-blinded study) to one of three groups: Control Group (CG), Treatment Group 1 (TG1), or Treatment Group 2 (TG2). Both TG were treated with Flogostop Duo (for 20 days—TG1 or 30 days—TG2) in combination with the standard treatment, while CG underwent standard treatment only. The standard treatment was nasal aerosol with Fluticasone and Mucolytic, and nasal washing with hypertonic solution. All patients were analyzed by otoscopy, impedance, fibroscopy, and pure auditory test at the baseline (T0), after 20 days (T1) and 35 days (T2). 120 children were included in the study, 40 in the CG, 40 in the TG1, and 40 in the TG2. Both TG1 and TG2 presented statistically significant differences with respect to controls in otoscopy, impedance, fibroscopy, and PTA at T2. The otoscopy improved at T2 with statistically significant value only in TG2. The impedance and fibroscopy improved at T1 both in TG1 and TG2 compared to CG. A statistically significant improvement was observed in TG2 at T2 in comparison to both CG and TG1. Statistically significant differences were observed in PTA at T2 only compared with controls. This study confirmed the efficacy of nutraceutical as supporting therapy in the upper respiratory tract infection in children. In particular, the supplement containing Boswellia serrata and Bromelain, which are molecules with strong anti-inflammatory and pain-control capacities, could add the benefit without the adverse effects which are related to NSAID use.

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“…Clinical guidelines for the management of patients with menstrual pain also include some non-pharmacological strategies or recommendations, such as exercise, healthy diet and natural remedies. Although there is no solid scientific evidence in this regard, the components of the preparation have antioxidant, anti-inflammatory and analgesic properties (35,41,47). Therefore, specialists recommend the preparation for its effectiveness in reducing pain as a complement to promoting healthy habits.…”

Section: Discussionmentioning

confidence: 99%

Study of the recommended dosage of the N-Acetyl Cysteine, Alpha Lipoic Acid, Bromelain and Zinc preparation as a treatment for dysmenorrhea

Estrada¹,

Carmona

2022

Preprint

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Dysmenorrhea, defined as pain during menstruation, is the most common gynecological condition, affecting a large percentage of women with varying degrees of pain. In recent years, the management of dysmenorrhea has become increasingly important because of the emotional, health and economic burden it entails and because of the need for new studies and research for effective treatments to alleviate its symptoms. The most common treatments for dysmenorrhea are NSAIDs or oral contraceptives, although gynecologists also recommend the preparation composed of N-acetyl cysteine (NAC), alpha lipoic acid (LA), bromelain (Br) and Zinc (Zn), (NAC/LA/Br/Zn) due to its anti-inflammatory and anti-oxidative properties and efficacy in reducing pain. However, there is no data on what dosage of the preparation should be recommended for patients with dysmenorrhea. Therefore, the aim of this study is to determine how the NAC/LA/Br/Zn preparation is recommended for the treatment of dysmenorrhea in daily clinical practice and what specialists base their decision on. A survey was conducted among gynecologists with extensive experience recommending the preparation, with a participation rate of 97% (N=73). The most frequently recommended regimen is to begin with continuous administration for 90 days with 10-day breaks (69%) or without breaks (31%). Specialists recommend the preparation for any type of pain and may recommend discontinuous administration (in the days around menstruation) when the pain is moderate or mild. In patients with primary dysmenorrhea with mild pain, the most recommended approach is discontinuous therapy in the days around menstruation (50.7%) followed by continuous administration for 90 days with 10-day breaks (24.7%). When pain is moderate or severe, the most recommended approach is 90-day continuous therapy with 10-day breaks (47.9% and 71.2%, respectively). In the case of secondary dysmenorrhea, the most recommended approach is 90-day continuous therapy with 10-day breaks for any degree of pain (41.1%, 57.5% and 76.7% for mild, moderate and severe pain, respectively). Most gynecologists (79%) adapt the regimen after clinical assessment of the degree of pain towards discontinuous administration patterns, on the days around menstruation. Most of the specialists consulted do not modify the recommended regimen if the patient is being treated with other drugs such as NSAIDs, hormonal contraception or a combination of progestogens (78%, 59% and 58%, respectively). The preparation is recommended in conjunction with hygienic-dietary measures without modification of the dosage (90%). This is the first study that addresses how specialists recommend the NAC/LA/Br/Zn preparation to patients with dysmenorrhea. The most common regimen for dysmenorrhea is to start treatment with continuous administration of the preparation for 90 days with 10 days of break, continuing the regimen or adapting it according to the degree of pain reported by the patient during treatment.

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Beneficial Properties of Bromelain

Cited by 59 publications

References 221 publications

Bromelain Protects Critically Perfused Musculocutaneous Flap Tissue from Necrosis

Bromelain Protects Critically Perfused Musculocutaneous Flap Tissue from Necrosis

Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Honey, Tyndallized Lactobacillus Acidophilus and Casei to Fight Upper Respiratory Tract Infection and Otitis Media

Study of the recommended dosage of the N-Acetyl Cysteine, Alpha Lipoic Acid, Bromelain and Zinc preparation as a treatment for dysmenorrhea

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