Benefit–cost analysis of moist exposed burn ointment

Atiyeh, Bishara S.; Dham, Ruwayda; Kadry, M.; Abdallah, Abdel Fattah; Al-Oteify, Mahmoud; Fathi, Osman; Samir, Ahmed

doi:10.1016/s0305-4179(02)00075-x

Cited by 45 publications

(33 citation statements)

References 12 publications

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“…In the past few decades, moist exposed burn ointment (MEBO), a Chinese burn ointment with a USA patented formulation since 1995, which was developed at the China National Science and Technology Centre in Beijing in 1989 (23,24), has been used to treat thickness burns in clinical practice and has achieved beneficial efficacy (25)(26)(27)(28) (30) and that berberine exhibits antimicrobial effects (31). Clinical and experimental studies have shown that MEBO exhibits analgesic and antimicrobial effects, and reduces the treatment time of burns (25)(26)(27)(28)32,33).…”

Section: Introductionmentioning

confidence: 99%

Moist exposed burn ointment promotes cutaneous excisional wound healing in rats involving VEGF and bFGF

Tang

Han

Feng

et al. 2014

Molecular Medicine Reports

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Abstract. Cutaneous delayed wounds are a challenging clinical problem, and vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) exhibit key roles in wound healing. Moist exposed burn ointment (MEBO), a Chinese burn ointment with a USA patented formulation, has been reported to promote chronic ischemic and neurogenic ulcer healing in patients; however, the underlying mechanisms remain unclear. In the present study, MEBO significantly promoted the formation of granulation tissue in cutaneous excisional wounds, shortened the time of wound healing, and increased neovascularization and the number of fibroblasts. Furthermore, as well as enhancing the protein expression, MEBO application also increased the gene expression of VEGF and bFGF. The results indicate that MEBO promotes cutaneous excisional wound healing by at least partially enhancing VEGF and bFGF production, implicating the potential uses of MEBO for delayed cutaneous wound healing. IntroductionCutaneous wounds, known as ulcers, are an extremely common clinical problem and often arise following acute or chronic mechanical causes, physical or chemical burns, frostbite, infections, and disorders, including rheumatism, diabetes, peripheral vascular disease, lipodermatosclerosis and malignant tumors (1,2). Furthermore, cutaneous wound healing may be significantly delayed due to the aforementioned factors. At present, delayed cutaneous wounds are one of major burdens for health care, and lead to a reduced quality of life in patients who suffer from this type of wound (3,4).Wound healing is a complicated biological process involving a series of dynamic events, including hemostasia, inflammation, cell proliferation and differentiation, neovascularization, granulation tissue formation, collagen synthesis, epithelialization, and wound contraction. Increasing evidence has established the hypothesis that growth factors, including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), are key regulators of normal and abnormal angiogenesis, and tissue repair in animals and humans (5-8). VEGF promotes angiogenesis/vasculogenesis and vascular permeability, and enhances endothelial cell proliferation and migration as well as the adhesion of leukocytes (5,9). Further research revealed that VEGF stimulates hydrogen sulfide synthesis and release from endothelial cells, thus leading to subsequent endothelial cell growth, migration and permeability, microvessel formation, and wound healing (10). In addition, VEGF promotes epithelialization and collagen deposition in the wound (11). FGF-2, known as bFGF, is a member of a large FGF family and induces angiogenesis, endothelial cell and fibroblast proliferation, and wound healing (12)(13)(14). Recent data indicated that bFGF-mediated angiogenesis refers to endothelial cell proliferation, migration and tube formation by activating c-Jun N-terminal kinase/stress-activated protein kinase signaling (15). Notably, the expression of VEGF and bFGF was increased following skin in...

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Section: Introductionmentioning

confidence: 99%

Moist exposed burn ointment promotes cutaneous excisional wound healing in rats involving VEGF and bFGF

Tang

Han

Feng

et al. 2014

Molecular Medicine Reports

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“…The result is similar to that other studies. 6,8 Atiyeh et al 8 used a different topical antiseptic cream (MEMO) keeping the patient exposed without applying any occlussive dressing. 8 The reduced length of hospital stay depends on the depth of burn, % TBSA, presence or absence of wound infection , number of operative procedure done etc.…”

Section: Discussionmentioning

confidence: 99%

“…The finding is almost similar in our study. Atiyeh et al 8 found that the use of moist exposed burn ointment (MEBO) without any dressing resulted in statistically very significant decrease in overall direct treatment cost. MEBO application also reduces the cost.…”

Section: Discussionmentioning

confidence: 99%

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Management of Paediatric Second-degree Burn in a Developing Country: With or Without Closed Dressing?

Ullah¹,

Ferdous²,

Haider³

et al. 2013

Chattagram Maa-O-Shishu Hosp. Med. College j.

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Objective: Our objective was to observe whether second-degree burn wound management can be done without using any occlusive dressing than conventional occlusive dressing in children. The purpose of this study was to evaluate our experience and to see the results of open dressing versus closed dressing in management of second-degree burn in children. Methods: A prospective comparative study was done on children (0-12 years) presented with second-degree burn during the period of August 2009 to December 2010. More than 10% total burn surface area (TBSA ) involving any region of the body and any percentage of TBSA involving the hands, feet, face, and perineum were included. Patients arrived only after 24 hours after burn; burn with other systemic illnesses were excluded. By randomized controlled trial (RCT) sampling technique, study population was divided into two groups-group A and group B. In group A, exposure or without dressing technique was followed and in group B, occlusive dressing technique was followed. Results: 125 patients were treated in each group. Age range was from 2 months 15 days to10 years. The range of mean length of stay (LOS) in the hospital in group A was 5 to 26 days and in group B, 7 to 43 days. In group B, 42% (52) patients had wound infection, but in group A, it was only 15%. Pseudomonas infection in group B was found in 40 cases. In group A it was only in 5 patients. In group B, 94% patients needed cleaning and dressing under general anesthesia and in group A it was only 12%. Eleven patients from group B needed skin grafting, but none from group A needed it. Mean total costs of management was USD 111.13 in group A, it was USD 182.85 in group B. Conclusion: The present study demonstrated that the open or exposure or without dressing method is suitable and effective in reducing patients' morbidity when compared to the closed or with occlusive dressing method for the management of second-degree burn wound in children. This method is also significantly cost effective.

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“…Few studies have examined the cost associated with burn patients' care, still fewer researches have reviewed the pattern of drug utilization and the cost of the medications in the management of burns. 9,10 The present study was done to know the pattern of drug use in the management of burns patients in a tertiary care rural set up like ours in a developing country like India.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of drug prescribing pattern in burns patients in a tertiary care rural hospital

Agrawal¹,

Patel²,

Karelia³

2015

Int J Res Med Sci

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Benefit–cost analysis of moist exposed burn ointment

Cited by 45 publications

References 12 publications

Moist exposed burn ointment promotes cutaneous excisional wound healing in rats involving VEGF and bFGF

Moist exposed burn ointment promotes cutaneous excisional wound healing in rats involving VEGF and bFGF

Management of Paediatric Second-degree Burn in a Developing Country: With or Without Closed Dressing?

A retrospective study of drug prescribing pattern in burns patients in a tertiary care rural hospital

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