Benefit of antibiotic therapy on pouchitis after ileal pouch anal anastomosis: A systematic review and meta-analysis of clinical trials

Elahi, Behzad; Nikfar, Shekoufeh; Derakhshani, Shaghayegh; Vafaie, Mohammad; Abdollahi, Mohammad

doi:10.2478/s11536-009-0019-4

Cited by 8 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These disparate results highlight the need for additional strategies to identify and characterize disease-inducing bacteria. The non-germ-free approach we used here generates healthy, IBD-susceptible mice by pre-treating conventionally raised animals with antibiotics that have been widely studied in human IBD (Elahi et al, 2009; Ohkusa et al, 2010; Rahimi et al, 2006). We showed that antibiotic treatment eradicates certain bacterial subsets from the microbiota, enabling us to experimentally colonize antibiotic-pretreated animals with primary isolates of commensal bacteria indigenous to our mouse colony and specifically quantify colonization using culture- and molecular-based techniques.…”

Section: Discussionmentioning

confidence: 99%

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

Bloom

Bijanki

Nava

et al. 2011

Cell Host & Microbe

437

331

View full text Add to dashboard Cite

SUMMARY The intestinal microbiota is important for induction of inflammatory bowel disease (IBD). IBD is associated with complex shifts in microbiota composition, but it is unclear whether specific bacterial subsets induce IBD and, if so, whether their proportions in the microbiota are altered during disease. Here we fulfilled Koch’s postulates in host-genotype-specific fashion using a mouse model of IBD with human-relevant disease-susceptibility mutations. From screening experiments we isolated common commensal Bacteroides species, introduced them into antibiotic-pretreated mice, and quantitatively re-isolated them in culture. The bacteria colonized IBD-susceptible and non-susceptible mice equivalently, but induced disease exclusively in susceptible animals. Conversely, commensal Enterobacteriaceae were >100-fold enriched during spontaneous disease but an Enterobacteriaceae isolate failed to induce disease in antibiotic-pretreated mice despite robust colonization. We thus demonstrate that IBD-associated microbiota alterations do not necessarily reflect underlying disease etiology. These findings establish important experimental criteria and a conceptual framework for understanding microbial contributions to IBD.

show abstract

Section: Discussionmentioning

confidence: 99%

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

Bloom

Bijanki

Nava

et al. 2011

Cell Host & Microbe

437

331

View full text Add to dashboard Cite

show abstract

“…One of the consequences of SRUS is infection; that should be taken under consideration. Recently, the role of microbes in inflammatory lesions have raised much interest; the effectiveness of antibiotics and the benefit of probiotics in amelioration of inflammatory conditions in the colon have been confirmed by meta-analyses [18][19][20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

A report of 112 cases of solitary rectal ulcer syndrome from Iran

Derakhshani¹,

Pakzad

Vafaie³

et al. 2009

Open Medicine

Self Cite

View full text Add to dashboard Cite

AbstractSolitary rectal ulcer syndrome (SRUS) is a syndrome with symptoms such as rectal bleeding, obstructed defecation, straining at stool and incomplete evacuation, and rectal polyps. In the present study, the clinical features of SRUS among Iranian patients is reviewed. Records of 112 patients diagnosed with SRUS between 1997 and 2007 admitted to a special coloproctology clinic have been analyzed retrospectively. Of 112 patients with SRUS, 61 were male (54.4%) and 51 female (45.6%) with a mean age of 32.2 years (range, 16–64 years). The mean interval between onset of symptoms and final diagnosis of SRUS was 3.8 years (range, 1–14 years). Rectal bleeding (67%) was the most common symptom in both genders, while a feeling of fullness was the least common symptom, observed only in one woman (2%). Incontinence was observed in 4 women (7.8%) and 3 men (4.9%), comprising 6.25% of the total clinical presentations. There were 38 patients (33.9%) with mucosal prolapse and 2 patients (1.8%) with total rectal prolapse. In conclusion, rectal bleeding in the presence of constipation or diarrhea is the main sign for diagnosis of SRUS. This syndrome is usually misdiagnosed; it is frequently confused with inflammatory bowel disease (IBD) because the rectal macroscopic and microscopic lesions and true polyps of rectum are similar. We suggest that most of patients who are treating for IBD and true polyps without any response are suffering from SRUS. Regarding misdiagnosis between SRUS and IBD or rectal polyp, the exact prevalence of SRUS has been mistakenly underestimated.

show abstract

Rifaximin in the treatment of inflammatory bowel disease

Guslandi

2011

WJG

View full text Add to dashboard Cite

The gut microbiota plays a role in promoting and maintaining inflammation in inflammatory bowel diseases (IBD), hence the rationale for the use of antibiotics in the treatment of those disorders. Antibiotics, however, may induce untoward effects, especially during long-term therapy. Rifaximin α polymer is an antibacterial agent that is virtually unabsorbed after oral administration and is devoid of systemic side effects. Rifaximin has provided promising results in inducing remission of Crohn's disease (up to 69% in open studies and significantly higher rates than placebo in double blind trials) and ulcerative colitis (76% in open studies and significantly higher rates than placebo in controlled studies) and might also have a role in maintaining remission of ulcerative colitis and pouchitis. The potential therapeutic activity of rifaximin in IBD deserves to be further investigated and confirmed in larger, controlled studies. The optimal dosage still needs to be better defined.

show abstract

Benefit of antibiotic therapy on pouchitis after ileal pouch anal anastomosis: A systematic review and meta-analysis of clinical trials

Cited by 8 publications

References 40 publications

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

A report of 112 cases of solitary rectal ulcer syndrome from Iran

Rifaximin in the treatment of inflammatory bowel disease

Contact Info

Product

Resources

About