Benefit of mammography screening in women ages 40 to 49 Years. Current evidence from randomized controlled trials

Abstract

Background. Eight randomized controlled trials (RCTs) of screening mammography were conducted involving women ages 40 to 49 years at entry. Current data gathered for periods ranging from 7 to 18 years of follow‐up are available from these trials. Methods. Meta‐analyses were performed using a Mantel‐Haenszel estimator method to combine current follow‐up data from the eight RCTs of mammography that included women ages 40 to 49 years. Results. Combining all current data on women ages 40 to 49 years at entry into the trials yielded a 14% benefit from screening mammography, without statistical significance at the 95% confidence level. Combining all data on women ages 40 to 49 years at entry, excluding results from the Canadian National Breast Screening Study, yielded a 23% benefit to women invited for screening, with statistical significance at the 95% confidence level. Conclusions. These results suggest that screening mammography in women ages 40 to 49 years at entry can reduce mortality from breast cancer when combined with adequate follow‐up. Cancer 1995;75:1619‐26.

Women's Knowledge Regarding Screening Mammography at Oncology Teaching Hospital in Baghdad City

“…The findings of the present study have indicated that the highest percentage (40%) of the study sample were at age (40-49) year as shown in table (1) that is agree with Charles and Smart ,who state that the Mammography in women ages 40-49 may save lives (14) . Regarded marital status the highest percentage (78.7%) of the study sample was married as shown in Table ( 1) and that agree with Niels who stated that the highest percentages of women who participating in mammography screening are married (15) .…”

“…The results of present study have revealed that there is a moderate mean score in Items related to the knowledge domain starting from items no. (1,2,3,4,5,8,9,10,11,12,13,14) and low mean of score in only two items (6,7) (6) Mammography can decrease mortality rate of breast cancer and item no. (7) Woman needs mammography periodically; it is similarly to Michael, Who stated that the women in Nigeria have poor knowledge of breast cancer and minority practice Breast Self-Examination and Clinical Breast Examination.…”

Age-specific interval breast cancers in New South Wales and meta-analysis of studies of women aged 40–49 years

“…ammography screening for women aged 40-49 years has shown mortality reductions of 15-25% in randomised trials, [1][2][3][4][5] but this reduction is of marginal statistical significance and determining whether screening in this age group is effective has not been without controversy. 6 Compared with women aged 50-69 years, women aged 40-49 years have lower breast cancer incidence and mortality rates 4,7 and a longer period (10-14 years) before mammography screening shows breast cancer mortality reduction.…”

Bilateral analysis based false positive reduction for computer‐aided mass detection

“…1 It has been reported that early diagnosis and treatment can significantly improve the chance of survival for patients with breast cancer. [2][3][4] Although mammography is a powerful screening tool for detecting breast cancer,5 , 6 studies indicate that a substantial fraction of breast cancers that are visible upon retrospective analyses of the images are not detected initially.7 -9 It has been shown that computer-aided detection (CAD) can increase the cancer detection rate by radiologists both in the laboratory and in clinical practice. [10][11][12][13][14][15] In screening mammography, two mammographic views, cranio-caudal (CC) and mediolateral oblique (MLO) views are generally taken of each breast.…”