Purpose: Previously, we demonstrated the efficacy of rehabilitation programs after maxillofacial surgery. In the present study, we extracted and summarized recommendations for the successful and comprehensive treatment of malignant tumors in the maxillofacial area. Material and methods: We analyzed the medical histories and ambulatory cards of 107 oncological patients with postoperative maxillofacial defects who underwent various prosthetic procedures. Results: Using polyurethane plastics to produce a protective plate on the day of surgery is necessary to improve the shortterm results of orthopedic treatment. The classification of the defect, selection of prosthesis according to the classification, applying the prosthesis without delay, and functional restoration by articulation gymnastics and mechanotherapy compose of the comprehensive approach for the defect at maxillofacial area after surgery. Conclusions: We propose that integrating the benefits from each treatment method and rehabilitation process would further improve quality of life after resection of maxillofacial tumors.