Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

Henary, Maged; Kananda, Carl Mufungwa; Rotolo, Laura; Savino, Brian; Owens, Eric A.; Cravotto, Giancarlo

doi:10.1039/d0ra01378a

Cited by 177 publications

(112 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the structural properties of these HCN polymers (and hence their potential applications) as well as the single biomolecules and related organics found in them via chromatographic analysis all depend directly on the synthetic conditions used for their production [9][10][11][12][13] . However, despite the considerable developments in the area of microwave-assisted organic synthesis and polymerization in recent decades [14][15][16][17] , only one report describes the production of HCN-derived polymers from formamide using microwave radiation 18 .…”

mentioning

confidence: 99%

A dual perspective on the microwave-assisted synthesis of HCN polymers towards the chemical evolution and design of functional materials

Hortal

Pérez-Fernández

Fuente

et al. 2020

Sci Rep

View full text Add to dashboard Cite

In this paper, the first study on NH4CN polymerization induced by microwave radiation is described, where a singular kinetic behaviour, especially when this reaction is conducted in the absence of air, is found. As a result, a complex conjugated N-heterocyclic polymer system is obtained, whose properties are very different, and even improved according to morphological features, characterized by their X-ray diffraction patterns and scanning electron microscopy analysis, with respect to those produced under conventional thermal treatment. In addition, a wide variety of relevant bioorganics have been identified, such as amino acids, nucleobases, co-factors, etc., from the synthetized NH4CN polymers. These particular families of polymers are of high interest in the fields of astrobiology and prebiotic chemistry and, more recently, in the development of smart multifunctional materials. From an astrobiological perspective, microwave-driven syntheses may simulate hydrothermal environments, which are considered ideal niches for increasing organic molecular complexity, and eventually as scenarios for an origin of life. From an industrial point of view and for potential applications, a microwave irradiation process leads to a notable decrease in the reaction times, and tune the properties of these new series macromolecular systems. The characteristics found for these materials encourage the development of further systematic research on this alternative HCN polymerization.

show abstract

mentioning

confidence: 99%

A dual perspective on the microwave-assisted synthesis of HCN polymers towards the chemical evolution and design of functional materials

Hortal

Pérez-Fernández

Fuente

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Among the advantages offered by the use of microwaves in organic synthesis, are better yields and higher purity of the reaction products, energy saving, uniform heating and good reproducibility [ 123 , 124 ]. Due to the above, the use of microwave activation is now quite widespread among groups working in the area of organic synthesis, generating a large number of publications [ 125 , 126 , 127 , 128 , 129 , 130 , 131 ].…”

Section: Microwave Activation Under Solvent-free Conditionsmentioning

confidence: 99%

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

Avila‐Ortiz

Juaristi

2020

Molecules

View full text Add to dashboard Cite

One central challenge for XXI century chemists is the development of sustainable processes that do not represent a risk either to humanity or to the environment. In this regard, the search for more efficient and clean alternatives to achieve the chemical activation of molecules involved in chemical transformations has played a prominent role in recent years. The use of microwave or UV-Vis light irradiation, and mechanochemical activation is already widespread in many laboratories. Nevertheless, an additional condition to achieve “green” processes comes from the point of view of so-called atom economy. The removal of solvents from chemical reactions generally leads to cleaner, more efficient and more economical processes. This review presents several illustrative applications of the use of sustainable protocols in the synthesis of organic compounds under solvent-free reaction conditions.

show abstract

“…Henary et al . (2020) discussed the microwave‐assisted synthesis and medicinal applications of five/six‐membered heterocycles [6m] …”

Section: Introductionmentioning

confidence: 99%

The Riveting Chemistry of Poly‐aza‐heterocycles Employing Microwave Technique: A Decade Review

et al. 2021

View full text Add to dashboard Cite

The application of microwave technique in chemical laboratory rooted back in 1986 and found advantageous over conventional approaches. On the other side, poly‐aza‐heterocycles are influencing organic frameworks with a fascinating chemistry and well explored by employing microwave‐assisted organic reactions. In the present review, we have thoroughly updated rousing literatures of microwave‐assisted synthesis and reactions of various poly‐aza‐heterocycles viz., triazole, tetrazole, triazine, and tetrazine from the past decade (2010–2020). The expedient chemistry and enabling role of microwave heating for adequate chemical transformations of such heterocycles, which were more challenging using classical approaches, are appropriately elucidated. This review also highlights the potential applications of these heterocyclic scaffolds and their derivatives in different scientific domains. Remarkably, such chemical architects possess wide applications as crucial building blocks in synthesis of biologically relevant compounds, agrochemicals, and compounds of interest in material science.

show abstract

Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

Abstract: Nitrogen containing heterocycles are of immense research interest because they are often found as naturally occurring bioactive compounds.

Cited by 177 publications

References 104 publications

A dual perspective on the microwave-assisted synthesis of HCN polymers towards the chemical evolution and design of functional materials

A dual perspective on the microwave-assisted synthesis of HCN polymers towards the chemical evolution and design of functional materials

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

The Riveting Chemistry of Poly‐aza‐heterocycles Employing Microwave Technique: A Decade Review

Contact Info

Product

Resources

About