Benefits of Artesunate versus Quinine in the Treatment of Children with Severe Malaria at the National University Teaching Hospital of Cotonou

Sagbo, Godonou Gratien; Zohoun, Laeticia; Bognon, Gilles; Agossou, Joseph; Padonou, C.; Tohodjèdé, Yévèdo; Alihonou, Florence; Ayivi, B.

doi:10.4236/ojped.2017.73019

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Among which: malnutrition, dehydration and pneumonia [10] and meningitis in this study. Therapeutically, artesunate first, quinine and arthemeter are the molecules used [38] [39] as recommended by WHO [3].…”

Section: Epidemiological Aspectsmentioning

confidence: 99%

Severe Childhood Malaria in Two Health Districts of Cuvette-Congo

Engoba¹,

Moukassa²,

Obili³

et al. 2022

OJPed

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Introduction: Malaria is a public health problem. Severe forms of malaria are linked to high mortality. Objective: To establish the cartography of severe malaria in two health districts in Cuvette-Congo. Methodology: An analytical and cross-sectional study was conducted from January to September 2019 in two health districts of Cuvette-Congo. Children aged three months to 17 years diagnosed with severe malaria were included. The epidemiological, clinical and paraclinical variables were analyzed. The statistical tests used were Pearson's chi 2 and the corrected Yates test. Results: Out of 806 children hospitalized, 277 had severe malaria (34.4%). There were 144 boys and 133 girls, an average of 60.9 months old. Anemia n = 247 (89.2%), repeated seizures n = 66 (23.8%), were the signs of severity observed. The clinical forms were isolated (n = 237) in 85.6% and associated (n = 40) in 14.4%, including 210 (88.6%) anemic form and 27 (11.4%) neurological form. The death occurred in seven cases (2.5%). The predictors of death were coma, jaundice, hypoglycemia, thrombocytopenia, hepatomegaly, undernutrition, dehydration and delayed consultation. Conclusion: The large number of cases of severe malaria in Cuvette, often in children under five years old, requires that the national program for control of malaria be strengthened by insisting on a wide distribution of long-lasting insecticide-treated mosquito nets.

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Section: Epidemiological Aspectsmentioning

confidence: 99%

Severe Childhood Malaria in Two Health Districts of Cuvette-Congo

Engoba¹,

Moukassa²,

Obili³

et al. 2022

OJPed

View full text Add to dashboard Cite

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Artesunate versus Quinine in the Treatment of Severe Plasmodium falciparum Malaria at North Eastern of Democratic Republic of Congo: Parasites and Fever Clearance

Nd¹,

Jo²,

Mr³

et al. 2018

J Clin Exp Pharmacol

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Severe malaria is one of the leading causes of death in sub-Saharan African countries and Artesunate is the firstline choice recommended treatment by the World Health Organization. The objective of this study was to identify biological and clinical advantages of Artesunate compared to Quinine in the treatment of severe malaria in children. This study was a randomized and analytical study focused on children admitted to Pediatric Hospital Center Village of Kisangani with severe falciparum malaria, from January 1, 2015 to December 31, 2017. We assigned individuals children intravenous Artesunate 2.4 mg/kg given as a bolus (n=34) at 0, 12, 24 hours and then daily or Quinine 20 mg/kg infused in 5 or 10% Dextrose over 4 hours than 10 mg/kg infused every 8 hours (n=83). During our study period, a total of 117 children were included in the study. 34 were treated with Artesunate while 83 were treated with Quinine. The higher malaria parasites clearance average 1063174 Parasites/ µL (971 Parasites/ µL-1563 400 Parasites/ µL) concerned the preschool age. The malaria parasites clearance on 12 hours after administration of Artesunate was similar (79.1%) compared with 79.1% clearance obtained by using quinine. The fever clearance of children treated with Artesunate and Quinine was higher in the Artesunate group (91.2%) than in the Quinine group (88%) on 12 hours with significant statistic difference. This study concluded that Artesunate and Quinine present a similar clinic and biologic efficiency.

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Benefits of Artesunate versus Quinine in the Treatment of Children with Severe Malaria at the National University Teaching Hospital of Cotonou

Cited by 2 publications

References 14 publications

Severe Childhood Malaria in Two Health Districts of Cuvette-Congo

Severe Childhood Malaria in Two Health Districts of Cuvette-Congo

Artesunate versus Quinine in the Treatment of Severe Plasmodium falciparum Malaria at North Eastern of Democratic Republic of Congo: Parasites and Fever Clearance

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