Benefits of cannabis use for metabolic disorders and survival in people living with HIV with or without hepatitis C co-infection

Santos, Melina; Protopopescu, Camélia; Zucman, David; Marcellin, Fabienne; Wittkop, Linda; Miailhes, Patrick; Sogni, Philippe; Carrieri, Patrizia

doi:10.1097/qad.0000000000002480

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…As modulators of the endocannabinoid system, which is a main therapeutic target for treating diabetes mellitus (Veilleux et al 2019 ), cannabis compounds may exert a beneficial role on the development of diabetes in different populations (Bielawiec et al 2020 ; Wargent et al 2013 ; Jadoon et al 2016 ; Meah et al 2021 ), including HCV-infected people (Barré et al 2020 ). Observational studies have also highlighted a potential role of cannabis compounds in liver disease prevention in this population (Adejumo et al 2018 ; Santos et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

et al. 2022

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Background Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection. Methods Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models. Results Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37–0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19–0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38–0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI. Conclusions We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure. Trial registration ClinicalTrials.gov identifier: NCT01953458.

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Section: Discussionmentioning

confidence: 99%

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

et al. 2022

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“…In up to 25% of patients presenting with marijuana use, liver biopsy results revealed evidence of subclinical injury to hepatocytes [9]. Daily use of cannabis has also been linked to a higher risk of HIV co-infection than cannabis use on an occasional basis [10,11] Animal studies suggest that cannabinol can have different effects based on the particular receptor activated. Activation of cannabinoid receptor (CB) 2 is found to be hepato-protective, while stimulation of CB 1 is associated with steatogenic and fibrogenic effects.…”

Section: Discussionmentioning

confidence: 99%

Marijuana-Induced Acute Hepatitis: A Case Report

Abosheaishaa¹,

Nassar²,

Rasool³

et al. 2022

Cureus

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“…Furthermore, it has been found that people who consume alcohol at moderate to high levels with Cannabis are at high risk of liver fibrosis. Those patients who consume Cannabis every day, are found to have a considerably low Quetelet index compared to occasional users (25.2% versus 26.4%), were more prospective to those who consume Cannabis on the basis of medical prescription (57.1% versus 8.79%), and are highly prone to getting affected by HIV co-infection (39.3% versus 18.2%) ( Nada et al, 2017 , Santos et al, 2020 ). Liver safety concerns were raised in randomized controlled trials from healthy adults who received therapeutic daily doses of cannabidiol for ~ 3.5 weeks and it has been shown that consumption of cannabidiol by healthy adults caused an increase in serum alanine aminotransferase, consistent with drug-induced liver injury ( Watkins et al, 2021 ).…”

Section: Marijuana and Health Effects: Conflicting But Interesting Outcomesmentioning

confidence: 99%

Wonder or evil?: Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals

Datta

Ramamurthy

Anand

et al. 2021

Saudi Journal of Biological Sciences

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Cannabis sativa , widely known as ‘Marijuana’ poses a dilemma for being a blend of both good and bad medicinal effects. The historical use of Cannabis for both medicinal and recreational purposes suggests it to be a friendly plant. However, whether the misuse of Cannabis and the cannabinoids derived from it can hamper normal body physiology is a focus of ongoing research. On the one hand, there is enough evidence to suggest that misuse of marijuana can cause deleterious effects on various organs like the lungs, immune system, cardiovascular system, etc. and also influence fertility and cause teratogenic effects. However, on the other hand, marijuana has been found to offer a magical cure for anorexia, chronic pain, muscle spasticity, nausea, and disturbed sleep. Indeed, most recently, the United Nations has given its verdict in favour of Cannabis declaring it as a non-dangerous narcotic. This review provides insights into the various health effects of Cannabis and its specialized metabolites and indicates how wise steps can be taken to promote good use and prevent misuse of the metabolites derived from this plant.

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Benefits of cannabis use for metabolic disorders and survival in people living with HIV with or without hepatitis C co-infection

Cited by 5 publications

References 18 publications

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

Marijuana-Induced Acute Hepatitis: A Case Report

Wonder or evil?: Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals

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